
Jason Locasale
3.6K posts

Jason Locasale
@LocasaleLab
Scientist (metabolism, cancer, AI, health/longevity). Academic & scientific reform. Former: Duke, Cornell, Harvard, MIT. DMs open • dr.jason.locasale@gmail


@LocasaleLab I learned the hard way that advisory boards mean almost nothing.

To be clear, Eric is a smart, solid guy. But what @LocasaleLab is saying about the system is very true.

Flagship welcomes @EricTopol M.D., as Academic Advisor. A renowned physician-scientist, researcher, and author, Dr. Topol has long been at the forefront of advancing medicine through science and technology. His leadership at the intersection of digital health, genomics and AI has reshaped how we understand disease detection and prevention. We look forward to working with Dr. Topol as we as we accelerate a new era of preemptive health and medicine.

The same cycle that contributed to Prasad’s ousting appears to be expanding to others in leadership. It’s relentless criticism across news and social media that centers on narratives around individuals rather than engaging with the reasoning behind decisions. The risk is not only losing good people, but also deterring those who care about standards from stepping into or staying in these roles. That’s a problem for the institution, not just the individuals, and by extension for all who care about maintaining standards.

Ok this figure is pretty intimidating...


The entire NSF research budget is ~$9B/year. This is literally funding every awarded PI at every field and every institution. But we've decided that all of basic science is a rounding error in comparison to venture bets. Please consider funding basic science more.

It was an honor to testify in front of the @HouseCommerce subcommittee on health regarding healthcare affordability. We discussed consolidation and the demise of independent physician practice. My solutions include: Repeal section 6001 of the ACA which banned physician owned hospitals Reform Stark law Implement site neutral payments Reform 340B Use FMAP to encourage states to be pro-competition (repeal CON, eliminate non competes)

Exhibit A: "we now have 90% less funding for medical research... We are sacrificing our children's future", illustrated with a 'scientific graph' labeled FUNDING CALLS PLUMMET and accented with a big red arrow That was a reprise of 2024's proclamations of the same Not mentioned were the last 3 NIH budgets signed into law: - 2024, ~$47.6B - 2025, ~$48.3B - 2026, $48.7B In other words, this is what we get when 'Science is Truth' meets 'The end justifies the means'

@R_H_Ebright @LocasaleLab You don’t lay-off nurses and other essential personnel like when Medicare payments are delayed. Instead, you lay-off non-essential personnel. It should be the same with NIH delays.

@LocasaleLab Maby have lost their labs and more continue to lose them with delays and lack of funding in hand. I, myself, have had to downsize and could also lose my lab by the end of the year if none of my in process grants happen. There are real consequences to NIH not fundings grants.



BREAKING: @rosadelauro announces at a House Oversight hearing with NIH director Jay Bhattacharya that OMB approved the agency's apportionment last night. That means the agency should* have access to its appropriated funds — 42 days after its spending bill passed.



The “NIH is no longer functioning” narrative was always dramatically overstated. A delayed apportionment coming after a prolonged government shutdown was framed as institutional collapse rather than what it likely was: a lag in funding flow tied to broader delays in federal operations. That context was largely ignored. Instead, a handful of social influencers amplified by outlets like Science and Nature pushed a doomsday storyline that was far more dramatic than the underlying reality.

In 2020, after universities failed to report at least $6.5 billion in foreign funding, the Department of Education opened investigations into Harvard and Yale. U.S. higher-education institutions were, according to the Department’s report, “multibillion-dollar, multinational enterprises using opaque foundations, foreign campuses, and other sophisticated legal structures to generate revenue.” wsj.com/articles/educa…

Nearly a year ago, my wife went to the hospital for stomach pain. They did a CT Scan of her abdomen and thankfully didn't find anything serious. We got a bill in the mail of $9,117.42 I spent months talking to insurance, the hospital, billing appeals... I was told the claim was still processing. I was told the claim was out of the normal service area. I was told it wasn't clear it was medically necessary. I was told the insurance wasn't valid on the date of service. Finally, we got it handled, but it took well over 6 months from the day we got the first bill to the day we finished the process and paid. We did everything right. We have insurance. We pay our insanely high premiums every single month. It's just so frustrating. This whole healthcare system is broken, from top to bottom.

@LocasaleLab Just keep telling yourself that until China comes out on top. That’s the plan.

@LocasaleLab Progress is limited by lack of mathematical theories of biological behavior. More data is just noise when you lack a testable theory.
