O'Neill Lab

Our first papers have been published in npj Biological Timing and Sleep! 🎉 We're proud to share two studies that highlight the journal's mission to showcase high quality research on all aspects of sleep, circadian and other biological rhythms: buff.ly/3xyd3CE #npjbts

@DrBatmo @estere_s @AiweiZeng21 @Neurocool @dcswong @embojournal @ReviewCommons You may have seen some of the data presented by @DrBatmo at #SRBR2024 #srbr24 @SRBR_Outreach - central to how we understand all levels of circadian regulation in the cell

@DrBatmo Authors on twitter: @estere_s @AiweiZeng21 @Neurocool @dcswong @DrBatmo. Thanks to @embojournal and @ReviewCommons for an excellent, productive review process.

Out today! Circadian rhythms in proteome turnover, especially macromolecular complexes, which allow proteome renewal even under cellular proteostasis, osmostasis, and energy homeostasis constraints: embopress.org/doi/full/10.10…

Our latest work is out as a preprint on #bioRxiv ! Work by @Serffest , @PriyaCrosby and many others looking at #potassium rhythms in coupling between the #circadian clock and cell cycle. Collaboration with @partchlab @ONeill_Lab and @Alestang01 biorxiv.org/content/10.110…

@BugajLab Looks like you've got some condensates forming at the lower temperature. Have you measured whether Melt responds to osmolarity? (see nature.com/articles/s4158… for where I'm coming from)

Both translocation and clustering are powerful inducers that can control a range of intracellular biochemistry including signaling, proteolysis, and nuclear translocation.

A new direction for our lab: previously we've done lots with light-control of proteins, but below the proteins respond to temperature 🔥❄️, not light. The first of two preprints on our entry into thermal control of cells🧵. biorxiv.org/content/10.110…

Come join our team? We have a postdoc position open. Deadline 17th March mrc.tal.net/vx/mobile-0/ap…

A tweet back to circadian biology: John and Andrew @DrBatmo were interviewed on the EMBO podcast about the story behind our recent paper on physiological function of red blood cell rhythms. Link below

And save the date for an exciting #proteostasis conference @BabrahamInst 8-9 May next year! More details will be announced soon but it’s looking like a great line-up! 4/4

We've dabbled in another non-circadian project with @RachelSEdgar - showing that propylene glycol (PG) has robust virucidal activity in vitro and in vivo and efficiently abolishes influenza A and SARS-CoV-2 infectivity within airborne droplets: embopress.org/doi/full/10.15…

Nathan = O’Neill lab axe throwing champion 👑👑👑

@Nature @MargotRiggi @janetiwasa @RachelSEdgar @DeriveryLab @_JosephWatson @estere_s @AndreiMih23 @Lara_K_Kruger @KerrieMcNally1 @Corelli_1653 @MichalDudekPhD @Silvia_Bar01 @AiweiZeng21 @Neurocool @DrBatmo @jorgmorf @chrismil941 @guna_alina @brugueslab @voorheeslab @je_chambers @UKRI_News @HFSP @wellcometrust @royalsociety @EMBO @ImperialInfect @PoLDresden If anyone wants to know why this is relevant to understanding circadian timekeeping and the daily regulation of mammalian physiology, check out Stangherlin et al, 2021 (nature.com/articles/s4146…) and watch this space. There is more to come soon! 16/16

@Nature @MargotRiggi @janetiwasa @RachelSEdgar @DeriveryLab @_JosephWatson @estere_s @AndreiMih23 @Lara_K_Kruger @KerrieMcNally1 @Corelli_1653 @MichalDudekPhD @Silvia_Bar01 @AiweiZeng21 @Neurocool @DrBatmo @jorgmorf @chrismil941 @guna_alina @brugueslab @voorheeslab @je_chambers Thanks also to editors and anonymous reviewers who thoughtfully helped improve this work! and also to our funders @UKRI_News, @HFSP, @wellcometrust, @royalsociety, @EMBO, @ImperialInfect, Versus Arthritis, Grifols, the Alpha-1-Foundation, Volkswagen ‘Life’ and @PoLDresden. 15/16

In a departure from biological rhythms, we’re excited to share our work describing the role of macromolecular assembly & condensation in the acute buffering of cellular water potential, published today @Nature. A thread: 1/16 nature.com/articles/s4158…