Mac

Ive noticed that when I take TUDCA my eyesight improves, almost feels like I dont even need glasses

@Elijahkrings yeah oddly i do terrible with fasting can only do 16/8 without feeling likw utter trash wheras my brother has done OMAD or 24 hour fasting and feels amazing

One reason you feel worse on fasting might be explained by redox issues If your NAD/NADH ratio is off, tilted towards the latter NAD is missing for the SIRT1-PGC-1a axis which is a massive driver of proper adaptation to fasting This axis controls the mitogenesis, mitophagy and autophagy response, as well as the mitochondrial fusion & fission dynamics which are normally very protective Under chronic antigenic load, mitochondrial dysfunction or even malnourishment this can be impaired, which strains the body more than it benefits it I am not against fasting, but for many its not the way out of their disease state. It should be viewed as a later therapeutic lever to be pulled when you are ready

HOW TO FIX CHRONIC DIARRHEA If you're suffering with chronic IBS-D (diarrhea), it can be very difficult to fix. The most common reason for it are things like: - hydogren producing bacteria dysbiosis - issues with gut serotonin - enteric nervous system or nervous system issues - gut inflammation As such, I've developed a safe protocol that won't damage your gut, that you can apply, which for many which will provide resolution of symptoms. PROTOCOL Weeks 1-3 - soluble fibre or PHGG daily - glycine (10g for the day) - mg malate during the day, mg glycinate during night - 500mg molybdenum daily - morning sunlight for an hour grounded (skin exposed) - methyl b complex once daily Weeks 4-(with 6 or 12 pending progress) - s bouladii (6 billion IU - 3 times daily away from food) - MCT oil (tea spoon, 3 times daily away from food) - coconut oil (1.5xteaspoon, 3 times daily away from food) - colostrum (6g x twice daily away from food) - curcumin phytosome (1000mg, 2xdaily) - black seed oil (1 tsp, x 2 daily) - glycine (12mg daily) - melatonin (5mg at night) (only for 1st 3-5 days of phase) - zinc L carnosine (15mg daily) (ensure copper intake) - mg taurate (300mg at night) - mg malate (adding to water throughout day) - avoid high starch foods or foods that trigger you (as well as industrial seed oils, processed foods, and gluten) - avoid fruit except for berries and oranges - focus on yogurts, kefir, honey, berries, meats, seafoods, eggs, herbs - get light environment right (especially after dark) NOTE: This isn't a protocol anyone with gut issues should use. Only if diarrhea is your predominant symptom with little other obvious symptoms. You may experience die offs from this protocol - so be prepared for that and ask if you don't understand what that is. Before the end of the protocol, you should experience resolution of diarrhea if its working for you.

@BodyRecompExprt @BasedBiohacker Same here but I get massive brain fog with alpha gpc oddly

@BasedBiohacker I need about 9 eggs worth of choline per day due to c677t mthfr

too much choline will give you brutal headaches and brain fog why do people keep putting brutal doses in their supplement blends yes the studies do 900mg bla bla bla but you are a healthy young man who eats plenty of meat and eggs bro you do NOT need to supplement a GRAM of highly bioavailable choline

@Elijahkrings doea cdp choline work for this as well or only alpha gpc?

If you have SIBO, getting your ICV functioning correctly is of utmost importance Vagus nerve & cholinergic output is massively important: Electrical Stimulation, Massages, B1/B5/ALCAR/Huperzine A/Alpha GPC Also, do not neglect the loss of charge due to loss of melanin/water networks. This is tied to chronic inflammation, circadian disruption and low UV light

You're a slave until you realize that, not only is this a stone cold looksmatch, but that both their bodies are the result of exactly the same amount of effort.

@obntsdtd @DA_ResearchLabs how many grams did u experiment with?

@DA_ResearchLabs I had this for a while years ago and I did one time a high dose of niacinamide (like several grams) and it never came back to the same degree. To a lesser extent, I find that getting enough calcium, sodium, and fat soluble vitamins really helps as well.

Ejaculation makes me feel awful, and I still don’t understand the science behind it. Let me explain the situation and present my theories: When I do it, I feel zombified the next day. Zero motivation, physically weak / dizzy and worse balance. It feels like adrenal fatigue when I wake up, and it takes at least 2-3 days until I feel better again. When I don’t do it, after a couple of days I start feeling way more motivated and energized. After 1-2 weeks it gets too much, and I almost lose my mind. Feels like I’m on coke. Here are all my theories: 1) Abstinence increases testosterone -> more energy/motivation -> losing my mind because of high aromatization to estrogen (acts like cocaine in the brain) -> feeling bad after ejaculation because production (Leydig cells) is impaired, so baseline is low. Counter argument: AFAIK, T gets back to baseline after 7 days of abstinence + this theory would imply that even though the baseline is low due to impaired leydig cells, abstinence still somehow increases T significantly. 2) Prolactin stays elevated for multiple days even though it should decrease after a couple of hours -> reducing dopamine + generally decreasing energy production. 3) Prolactin decreases after a couple of hours, but the dampening effect on CRH persists for multiple days for some reason -> less ACTH -> less cortisol production -> adrenal fatigue. (In the past I’ve felt like my adrenals were a little sluggish) - ik prolactin can also increase CRH, but in the case of ejaculation I doubt it. 4) Ejaculation spikes my dopamine so much that my baseline adjusts for a couple of days (since dopamine compares & evaluates experiences) -> losing my mind at the end because thinking about sexual stuff makes me so dopaminergic. I know that I genetically have fast COMT (Val/Val) (breaks down dopamine), which tends to decrease my dopamine baseline (tonic) and shifts me toward big short term spikes (phasic) - making me more prone to dopamine depletion and trouble focusing when other thoughts pop up (sexual thoughts in this case), which induce phasic dopamine that might drive me crazy after some time because it’s quite a rollercoaster. 5) Not the ejaculation itself is spiking my dopamine, but simply repressing desires (abstinence) is -> at some point repressing desires is just too stressful -> CRH, Glutamate etc. increase which makes me lose my mind, and losing this motivator via ejaculation exposes me to the low dopamine baseline that I‘d normally have

@hexumlite no way u needed that high of a reta dose

A jacked streamer reveals he is currently taking 18 mgs of Retatrutide and this shit is not curbing his appetitite anymore He is also taking 315 mgs of testosterone rendering him infertile at 23 years old He claims he hasnt worked out in 2 weeks He says he is adding Cagrilinitide to this very soon Its like Jelly to Peanut butter for this leanmaxxing shit according to him

@gaezpeat Schisandra is an interesting one as well.

Prolactin Lowering Tools - Lisuride, Terguride, Metergoline - Bromantane - Gingko Biloba - Vit E, Aspirin, - LD. T.Progesterone - LD. DHT - LD. Exesmestane - HD. Salt - P5P, Zinc, T3, Sun, Calcium, Sugar, Apigenin, RJ, ttfd - LD. Rasagiline - 9mebc, modafinil, prl 8 53, mucuna

@BerbarianWizard Ray Peat has alwyas been right in his framework the nuance is in how to reach the states that are healthy by blasting t3 for metabolism or nuking gut bacteria with antibiotics or via other gentler more holistic means. Somewhere in the middle seems ideal

You’ll never guess who said that, and I won’t tell you. All you need to know is that Ray Peat ideas will become the health norm.

@kalos21million GHK CU makes my skin look amazing and really calmed my sebborheic dermatitis, makes sense that it has so many anti inflammatory properties

GHK-Cu article released two weeks ago

@aestheticprimal just low dose under 2 mg , just gets rid of impulsive actions. High dosing is where u fuck up

sexual deprivation, hunger, emotional voids are absolute essentials to occupy your highest self low-desire states have shown time and time again to be a jibe towards (personal) evolution itself the new gen of Prolactinmaxxed GLP-1 gooners will be the lowest form of humans to ever grace the earth

I have the same thing but less severe. it is more noticable when Im tired. Anyone know how I can correct this?

@user_________01 For sure glad its stabilzing foe you somewhat

@TMClash95 Not the root cause, yet. But haven't taken vit D in a few months and the level is slowly declining

Creatinine came back high still PTH still low Vitamin D in range since I've not taken it for months now Wonder if my kidneys are fukt from all the weird supplements I've tried

@BerbarianWizard How would you reccomend hopping off trt for someone very overweight? Would it be better to implement what you reccomend while on trt until enough weightloss then try to go off? or get off trt right away and try fatloss with diet + what u reccomend?

I’d remove testosterone, so no need for an AI like exemestane either. I’d also remove HCG and rFSH. I’d add low-dose progesterone, low-dose DHT, Epithalon, Pinealon, and Vilon. With that we might actually regenerate his thymus and reverse aging. I have doubts about HGH though.

@BowTiedHRT @nickcpicks make me aromatize way too much unfortunately

Male TRT without HCG is sorely lacking/incomplete. HCG is a non-negotiable for men on TRT even if fertility is not a concern. Benefits include: Mood boost Healthier testicular function Improved penile sensitivity Improved semen production Improved orgasm quality Why would you not use it?

Any of my peptide people collaborate this?

@gaezpeat @NotBasquiat06 Interesting luckily u tested . And I do experience estrogen sides rn with test so I lowered to only 20mg EOD and pair with dht p. I didnt experience any on topical t since it turns way more to dht. - Also for estrogen need drop bodyfat and get choline 900mg daily which is tough

@TMClash95 @NotBasquiat06 I got a weird condition i got low dhea, got my adrenal function tested with IV exo ACTH by a doctor they didnt find any cause. My cortisol is good That could be why i dont feel the estrogen sides. However rn im also on AI so i take bit more. Do u feel estrogenic on exo test??

1. Permanently upregulate 5AR with exogenous DHT 2. DO PROGESTERONE

@gaezpeat @NotBasquiat06 Thats a good stack. Ive noticed the same with the dhtp and also progesterone too interestingly as ling as I dont over do it. I need try exemestane again I liked it and dhea always make me estrogenic

@gaezpeat @NotBasquiat06 makes sense im doing trt along 5ng dhtp eod rn, what benefits have u noticed. Hopefully eventually i can get off the trt and just use low dose dhtp tbh