Mac
1.6K posts
My brother has a mild form of autism (ASD), and I'm going to be getting him extensive testing this year in order to find a resolution.
I feel quite confident I can definitely help him with a lot of his symptoms (predominantly, social interactions, emotional regulation).
Based on research it's not simply enough copper (although, it can be), it can be multiple nodes of the biological network that drives the biochemistry of ASD.
Copper makes sense for certain individuals who have insufficient oxygen utilization at mitochondrial complex IV (CCO), poor superoxide reduction (SOD1/3), melanogenesis (TYR), or heme protein assembly for oxygen transport, detoxification, vitamin D metabolism, or steroidogenesis (ceruloplasmin).
This may be reflective of a genetic impairment, or simply a lack of dietary copper.
But it could be a potentially horrible, debilitating intervention for another, where it could drive copper toxicity and hydroxyl radical formation via the Fenton reaction.
I will be getting my brother a GI map, OAT test, basic blood biochemistry, and I also have an active lactate / glucose / ketone meter, alongside HRV/sleep tracking, that I'll be able to use to test specific interventions that determine how well metabolic/mitochondrial health is working.
Meditation Teacher@embodiedthinkr
Hey guys I cured autism. It's not enough copper. Seriously. Hassan et al. (2025): ASD children: serum copper 192.6 ± 6.83 µg/dL Controls: 99.17 ± 14.58 µg/dL Copper ROC: AUC 99.6%, cutoff ≥ 121 µg/dL (sensitivity 96.9%, specificity 96.4%) Full paper: link.springer.com/article/10.118…
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@TMClash95 @JayCampbell333 Yes, it's like a tan. It fades over time with less sun
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M2 is a nearly worthless peptide.
Just shows you how utterly clueless most of the peptide using world is.
Darkens moles, causes horrific nausea and turns most users into orange oompa loompas.
Peptidepedia@peptidepedia
melanotan 2 timeline: > 2023: niche forums > 2024: bodybuilders > 2025: biohacker influencers > 2026: @sama, OpenAI CEO, is considering
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melanotan-2 doesnt only help you tan faster but also helps you tan in a way that leaves you with less damage
especially at the root, deep DNA level
it does this by reducing DNA damage and accelerating DNA healing from that same damage while activating anti-oxidant & anti-inflammation pathways
i used 50-100mcg a week and turned into a thug in the mediocre amount of sunlight we had during march in belgium
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KPV is quickly becoming my favorite peptide from a research perspective
Through mimicking Alpha-MSH, the hormone missing in all chronic disease states it powerfully acts on multiple pathways:
- modulates immune cells towards anti-inflammatory shift
- acts as a direct antimicrobial peptide
- powerfully inhibits transcription of inflammatory regulators (TNF-Alpha, Il-6, NFKB)
- lowers endotoxin induced inflammation
The CIRS generation, chronically low in MSH and destroyed leptin signaling can seriously benefit from this
250-500mcg daily will be my new experiment for the next weeks. I will update
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@BodyRecompExprt @JayCampbell333 this dose prevented darkening of moles? did moles reverse to previous lightness after stopping?
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@JayCampbell333 My experience was different. Got a great tan but was so bricked up in bed, that is interefered with my sleep
It did darken some moles, but I just had to reduce dose
The best strategy for me was 200-300mcg ~3/week with 20 minutes of daily sun exposure
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Many guys want to jump on Testosterone 💉 to improve libido
When the hormone they really need is a-MSH
Sure, correcting low T will help
But MSH holds the doors to increased mating behavior
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The most important role of electrolytes beyond their ability to regulate a cell's voltage potential is there ability to control the distribution (osmolality) of water networks extracellularly and intracellularly, but more specifically, controlling water concentrations within organelles of that particular cell.
Potassium (K+) is of high importance here, as it's the main electrolyte that brings water inside cells, and enables the maintenance of that water intracellularly.
And the hierarchy goes (put simply):
— If you lack sodium, chloride, or bicarbonate (think acidosis), you can't bring water across your gut lining
— If you lack sodium, you can't bring water into your blood
— If you lack magnesium or ATP, you can't pump that water inside your cell
— If you lack potassium, you can't bring water intracellularly
— If you can't get potassium inside your mitochondrial matrix, the volume of your mitochondria is compromised and you make insufficient ATP + H2O (DDW).
— If you have an electrolyte imbalance (due to stress, dietary intake, acidosis), then you can't properly regulate the precision of these electrolytes, thus the distribution of water.
The biological implications of this go far beyond muscle cramps and nerve conduction (although, still occurring).
The biggest problem here is that enzymatic reaction, protein fold, and electron transfer in respiration all require a precisely structured aqueous environment that's governed by electrolyte status (which ironically is governed by energy status)
Your health comes down to how well your cells can hold and organize water, which interacts/hydrates everything that it touches.
Jack@jack_schroder_
Potassium is fundamental to mitochondrial water volume, this is important to know because most people are lacking sufficient potassium in their diet (optimal target = >4500mg/day) Potassium, much like sodium, attracts water. Potassium likes to not only concentrate itself in the cytosol, but also in the mitochondrial matrix. Proper mitochondrial matrix volume and membrane potential are tightly coupled. When potassium balances water inside the matrix, it allows for the cristae to open up and the electron transport chain (ETC) complexes to spatially organize themselves in the most efficient way possible for energy generation. Essentially, it allows for sufficient surface area for respiration to run correctly, whilst preventing swelling (provided it's in balance). Low potassium leads to the matrix over-contracting, where cristae start to compress and the proton gradient that drives the ETC + ATPase is disrupted, leading to a lack of energy generation from fuel. You need sufficient sodium to bring the water into the blood, then you need sufficient magnesium (alongside ATP + mitochondrial function) to bring the potassium inside the cell via the Na/K-ATPase. To bring potassium inside the mitochondrial matrix, it relies on ATP-/calcium-sensitive channels to activate. These are gated and are open in response to signals (energy demand, calcium flux, membrane potential, etc.) Calcium can also be stored inside the matrix and also draws water in, but it also acts as a more potent signal so needs to be balanced. So electrolyte imbalances not only affect nerve signalling, heart beats, muscle contractions, but also your mitochondria themselves.
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@BerbarianWizard anyway to offset or reverse the thymus effects if already on trt for a a few years?
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Start TRT because it’s S-tier, tell your thymus to fuck off, you can neglect sleep and pull all-nighters since it’s C-tier. That’s what Hans Amato tells you, he’s the expert (even though he used to say treat the output, not the signal).
Also, cocaine > sugar.
Hans Amato@HansAmato
Fixed it for you...
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@spheno_xiphoid @TheMitoBro what was this in reponse to if you dont mind me asking? pairing 9me bc with what? with psilocybin?
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@TheMitoBro First time, I paired it with 9-me-bc and had somewhat of a psychedelic experience with more vivid colors and changes in my perspective of reality. Long term it totally rewired my dopaminergic system. Also, combine it with phenylalanine for best results.
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@hexumlite Abundance is mentality as well. Best to have bros with abundant mentality when it comes to woman otherwise theyll betray you. Dudes who cant or never got pussy are usually sleazy
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Mac retweetledi
Inflammation + infection depletes your vitamin C reserves — this is a big deal.
You need vitamin C to recycle vitamin E, and you need vitamin E to prevent your cell + mitochondrial membranes from becoming oxidized.
If you lack vitamin C, you shunt more homocysteine down the transsulfuration pathway to make more glutathione to compensate for the low vitamin C and oxidized vitamin E.
This leads to undermethylation, leading to poor detoxifcation, dysregulation epigenetic programming, low melatonin, adrenaline, creatine, choline, and a lack of clearance of histamine, dopamine, and catecholamines.
A lack of vitamin C leads to increased demand of CoQ10 + alpha-lipoic acid, which leads to bottlenecks in TCA cycle + ETC.
If you lack vitamin C, you can't make BH4 properly, which means you can't make dopamine, serotonin, melatonin, or nitric oxide.
It also means you can't make collagen, carnitine, or bile acids (tied to detoxification, fat/vitamin absorption, and antimicrobial effects).
It means you can't recycle iron properly to be absorbed, nor for its role in inactivating cellular hypoxia/HIF-1a (even in presence of oxygen)
You also can't govern the release/synthesis of POMC products (eg., alpha-MSH, endorphins), oxytocin, vasopressin, sex + steroid hormones, thyroid hormones, and growth hormone/IGF-1.
I would suspect that most individuals who are surrounded by modern world stressors would do well with 250mg/day of vitamin C, 1-2x/day (on top of food intake + sufficient vitamin E, glycine, cysteine, protein in general).
Optimize gut health + endotoxin + stressors load to ensure that vitamin C reserves stay sufficient and don't run suboptimal.
Jack@jack_schroder_
Gut dysbiosis leads to an excessive endotoxin load that depletes vitamin C, which then prevents vitamin E from being recycled. When you can't recycle vitamin E, your cellular, mitochondrial, and organelle membranes deal with excessive oxidative stress/lipid peroxidation, which then leads to further dysbiosis and disease in general.
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@TMClash95 @BowTiedUM Copper iud has no hormones, I’ve had one and it didn’t mess me up like the hormonal birth control at all. Eventually removed it because it caused spotting - but definitely different than the hormonal birth control or IUD.
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She's on birth control when she gets married
Noseblind to his estrogen dominance and lack of 5AR
She comes off and biological reality takes over
Fraudulent pairbond
Many many many such cases
“Bad” Billy Pratt@KILLTOPARTY
Damn, she really hates him
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@BowTiedUM mfw: girl im talking to has copper iud
gonna inject 250mg some dht now
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@Rachmanifold - tendency to say something to shopping cart non-returners
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Signs your blast is starting to kick in:
- Wanting to beat people up (but not because you're mad at them, just because it would be awesome- IYKYK)
- Breaking out in maniacal laughter at times normies consider inopportune (not that you care)
- A profound urge to type in all caps all the time
- Impatience with lethargic or apathetic people
Basically like every video of Tom Platz
@AntiDoc
Any other you'd add?
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In an effort to build the limitless pill with polypharmacy one cannot discount memantine
This shit is a super drug
Memantine is a “smart” NMDA antagonist and an open channel blocker. It suppresses overactive glutamatergic neurotransmission while leaving physiological NMDA intact.
It does this by binding 2 receptor sites of NMDA and reducing excitotoxicity, blocking the channel only while it’s open
Absolutely elegant mechanism of action. Glutamate is an inhibitory neurotransmitter involved in:
• ramp up excitatory states
• steroid-induced neurotoxicity
• development of neurodegenerative diseases like Alzheimer’s and dementia
• depression and suicidal ideation
• synaptic dysfunction
• suppression of long term potentiation (LTP)
Glutamate plays important roles in learning and memory, so presynaptic blockade such as with pregabalin is neurotoxic. Thus, we want to inhibit overactive surge without downregulation of neurotransmission.
Memantine repairs this by restoring the regulatory induction threshold for LTP, blocking overactive glutamate, and functioning as a structural metaplasticity enhancer. Unlike ketamine, another NMDA antagonist that activates downstream plasticity cascades like mTOR and NGF, memantine rewrites the rules on plasticity. This phenomenon is known as Hebbian plasticity, in which “neurons that wire together fire together.”
Clinical outcomes include:
• chronic pain relief
• reduction in autism-induced social dysfunction
• anti-anxiety
• anti-inflammatory and anti-apoptotic effects
• neuroprotection
• restoration of sleep
• mood enhancement and anti-depressant like effects
Well tolerated, safe, and extremely well documented. The fact biohacker bros on X don’t talk about memantine shows how little they truly know about cognitive enhancement.
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there are 2 stages in life
the one before pinealon, and the one after pinealon.
- no more brain fog
- way less prone to procrastination
- feel sharper all day long
- no longer crashing in the afternoon
- no longer groggy after waking
- perform better on days with less sleep because my sleep is more efficient (more REM, deep sleep)
- baseline cognition just feels elevated compared to before. i perform way better on no-stim days, AND on days i take stimulants
- life is just more beautiful
1-2 capsules in the morning. start with a 30 day cycle, then trust your gut.
this stuff is not cheap, but the discount code BASED gives you a 10% discount on the best oral pinealon that exists. full disclosure: this is an affiliate link.
US: yourprotocol.co/products/pinea…
EU + worldwide: mandimart.eu/en-se/products…
UK: mandimart.co.uk/products/pinea…
BasedBiohacker@BasedBiohacker
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