Sean

Aging better is the new Bitcoin 💰 🧬

@mmeJen It already hit a few years ago. Anyone who tracks their earnings knows it's just getting worse from here. Boiling frogs and all that. 🐸 🔥 🍲

Believe it or not, your normie friends will not appreciate you warning them that an economic tidal wave is about to hit us and it will last for years. Ask me how I know.

@icanvardar 95%, optimized to extract more activity from Humans and human-NPCs. Ask yourself: what would "blue book" do?

i’m convinced 75% of twitter accounts aren’t even real people

@bryan_johnson If sauna was anything significant, millions of Finnish people would be aging better. Back to the drawing board

I think I need to be fired. I've done 232 dry sauna sessions. Last week I confirmed, for the first time (by swallowing a pill), whether the core temperature threshold that gates the primary cellular repair mechanism was actually being reached in my protocol. The threshold is 102.2°F (39.0°C). For me, that takes 33 min at 195°F. With ice on face and neck, 38min. My standard daily protocol was 20 minutes. That wasn’t enough time to get my core body temp to the heat shock threshold of 102.2°F (39.0°C). Causing me to ask, did I just waste 77 hours and 20 min? It's possible my heat threshold has increased and the heat shock protein release was happening previously, but I doubt it based upon the subjective feeling I now understand as being 102.2F (39.0°C). It’s brutal. For these 232 sessions, I measured the temperature of the air, humidity, duration, frequency, the sweat output, blood biomarkers, vascular response, toxin clearance and fertility markers. There is no human body in history that has been more measured in sauna than mine. Nevertheless, I did not confirm the one number that determines whether the primary mechanism was activating. My goal wasn't to be a sauna bro. It was to saunamaxx. I was doing the former while thinking I was doing the latter. I rest my case. I should probably be fired.

We're still in the stone age for anti-aging. pharma and all the Harvard lab managers want to keep this molecular subscription model to marginally useful NAD+ boosters, glutathione etc. Direct energy stimulation of stem cells, and other rejuvenation processes, with UV bio-photons, vibration etc who knows what but it's coming in a few decades.

Aging does not happen linearly, but in bursts. We experience acceleration periods where gene expression shifts rapidly once we reach a damage threshold. Your body compensates until it doesn't. This is why some people can age 10 years in 2 and some people can look the same after 2 decades. The logical approach then is to not slow down aging per se, but to prevent these thresholds from collapsing prematurely. These shifts are natural (eg puberty, menopause), but their acceleration doesn't have to be. Chronic stress, the biological kind, is clearly an accelerator for these aging thresholds and should be northstar priority.

@BrianAtlas 😂 in other words he's an 8+ and she's a 5 or below (typical SMV gap to attract a woman these days), she thought she'd locked him down but he's jumping at any excuse to run

BRUTAL RED PILL...

@jdpower96 @TheLaurenChen it's more proof that most people are NPCs 🦞 🦐 💩 🤢

@TheLaurenChen I don't know why sea bugs are considered a delicacy. You are eating water roaches.

One seafood buffet accepts food stamps as payment And they even give a DISCOUNT if you pay with EBT Does anyone else think it's weird to have low-income people eating all-you-can-eat crab legs at restaurants on the taxpayer's dime?

@davidasinclair @JoinLifespan love this Orwellian corporate name 💕

At Lifespan, we care about you, your loved ones, and humanity. A special project is to record and safeguard human knowledge and biological information, so civilization and our biology can be restored if lost. @joinlifespan, and let's achieve longevity for both you and humanity🌎

@bryan_johnson Respect the disclosure. The persistence of that nasolabial line is frustrating after RF devices and skin boosters. Lesson for all of us: Easier to maintain legit adipose volume and ECM structure than to rejuvenate it

Results from my Feb 23 skin therapy: Improvements since treatment: > Brown spots: +71 percentile points (20th → 91st) ✅ > Pores: +25 percentile points ✅ > Spots: +25 percentile points✅ My skin age is 9 years younger than my chronological age (39 vs 48) and hasn't aged in five years since starting this project. Effectively a 9 year age reversal. Measured using VISIA multispectral clinical imaging, the most validated non-invasive skin analysis system available. Feb 23 treatment summary Technologies > Everesse RF > CoolPeel CO2 laser > BBL Each targeting a different skin depth so repair windows overlap without competing. Treatment details Everesse RF (200 pulses, Level 2.5 per cheek), CoolPeel CO2 laser (3.0W, 700 micron spacing), and BBL broadband light. Each targeting a different skin depth. Everesse drives heat into the dermis at 60-70°C, triggering fibroblast activation and collagen production that peaks 6-8 weeks later (about now), tightening the structural scaffolding that makes pores visible. CoolPeel ablates the surface layer of skin, physically removing melanin-loaded cells and forcing fresh keratinocytes to the surface. BBL destroys residual pigment one layer deeper through selective photothermolysis, where melanin absorbs light energy and self-destructs. Porphyrins dropped 13 points, which is expected. The treatments temporarily disrupt the follicular environment that bacteria need to thrive, and that recovers within 8-12 weeks. Goal was to do a triple-modality stack so the repair windows overlap without competing (dermis, epidermis, and chromophores).

@giveashitnature Seems like a good reason to not eat oysters lol 🤢

Same water. Same tank. But the one on the right has oysters. A single oyster can filter up to 50 gallons of water a day. Oyster reefs in the Chesapeake Bay once filtered the entire Bay, 19 trillion gallons, in under a week. Today, with less than 1% of the original oyster population remaining, it takes over a year. We ate them. We dredged their reefs. We dumped nitrogen into their water until the algae blooms choked what was left. And now we build billion dollar water treatment plants to do what oysters did for free. The Billion Oyster Project is working to restore oyster reefs in New York Harbor. Restored reefs in Maryland's Harris Creek can now filter the entire creek in under 10 days and remove nitrogen equivalent to 20,000 bags of fertilizer every year. Nature had this figured out. We just have to restore the oysters and get out of the way.

@maximumpain333 You're literally making this up. And probably written by AI.

The most dangerous lie in human history isn’t about food. It isn’t about medicine. It is about sleep. For 200,000 years, humans did not sleep 8 hours. That number was invented in 1938 by a mattress company called Simmons Beautyrest. Before that campaign, the average human slept in two shifts. Historians call it “Biphasic Sleep.” You would sleep for 4 hours, wake up for 2, then sleep for another 4. During that 2-hour window, people would pray, have s*x, write, think, and connect with their families. Some of the greatest works in human history were created in that sacred middle window. Shakespeare wrote most of his plays between 1AM and 3AM during his second wake period. Mozart composed entire symphonies in what he called “The God Hours.” Then the Industrial Revolution needed workers on a fixed schedule. You cannot run a factory on biphasic sleep. So they hired a psychologist named Dr. Nathaniel Kleitman to “prove” that 8 consecutive hours was the biological standard. He faked the studies. He was funded entirely by the mattress industry. And the medical establishment adopted his research without question because it aligned with the factory model. They turned the most creative 2 hours of human consciousness into a “sleep disorder.” They called it “Insomnia.” They medicated it. They gaslight an entire generation that 8 hours of continuous sleep was healthy. They pathologized the exact window of consciousness that produced some of the greatest art, music, and literature in human history. You are not an insomniac. You are experiencing the most natural form of human consciousness. And a mattress company convinced you it was a disease. Stop medicating your genius. Wake up at 2AM. Write the thing. The “God Hours” are calling. ✨🙌🏾💫 © Andre Gonzalves

@vanillakasha @davidasinclair tried B6 p5p?

@davidasinclair I don’t care about controlling aging. I just want this nerve pain to stop.

This kind of post infuriates my science colleagues & fuels trolls We’ve published that we have reversed the epigenetic age of nerve cells. That’s true! Reversing the age of entire mice is not When claims get exaggerated like this, how’s anyone supposed to know what’s real?

@elonmusk It's cool to achieve things on your own. Under a corporate bureaucracy, everything is LinkedIn-energy / Tax slave fucking cringe pathetic.

My idea of a good time is working with amazing engineers to create incredible technology 🤩 The Tesla chip research fab will have all the machines needed to do logic, memory, packing & masks in one building for a lightning fast development cycle. Heaven 💫

@EmeraldRobinson Due to his accelerated aging, he won't be around to know if this happens in 20 years

If Bill Gates feels OK appearing on TV to tell you that your entire life is optional, then you know: we're not winning right now.

@Vision4theBlind She's obviously a mentally ill parrot. This means nothing.

Grimes, the mother of three of Elon Musk's children: "Luckily there is a massive population drop coming..." They know what's coming.

@bryan_johnson Also outgassing from cheap gym equipment, and indoors

Guys, I’m an idiot. All this time I’ve spent trying not to die, I had toxic turf in my backyard. Artificial turf contains crumb rubber infill made from recycled tires, which leaches chemicals including PFAS, heavy metals, and polycyclic aromatic hydrocarbons. These compounds are linked to hormone disruption, carcinogenicity, and systemic inflammation. I don’t know how I missed it. It makes me question my basic competence in life. What gets me is that I try so hard to survey the world of potential idiocy. Then I find out there’s a monument to idiocy sitting right in front of my face that I was blind to. I’m removing the turf, yet I’m still stuck with this seemingly unsolvable problem of how to not be an idiot.

@bryan_johnson Ultimate cringe, no wonder the "rejuvenation Olympics" is a grift to sell test kits and promote YouTubers

They ported the 5-MeO-DMT pathway from the Sonoran Desert toad into tobacco plants and then used AlphaFold3 to debug the protein structure, leading to a 40x yield increase. Prompt psychedelic design.

@ze_rusty @photobiogenesis but lithium orotate is almost exclusively -7

lithium comes in two isotopes lithium-6 and lithium-7 a 1986 paper found they have completely different effects on bipolar disorder same element. same charge. same chemistry. DIFFERENT NUCLEAR SPIN. the psychiatric drug that's worked for 70 years works because of quantum mechanics NOT PHARMACOLOGY and nobody in psychiatry knows this

Yes, I've been pushing this TRUTH for years, people are so dumb. Just accept the fact that it's over. 🔥 If it was illegal to digitally outsource, then this economy would still have a chance. Not gonna happen. Game fucking over. All those genuine tech innovations, from '90 to 2010s. Not anymore. Corps literally asking people who haven't had a raise or promotion in years to volunteer innovations we've seen. lol fuck them.

@SanDiegoKnight He confirms what I've been saying. H-1B visas are a drop in the bucket. The REAL issue is hiring REMOTE workers for US jobs from foreign countries. BTW Mexico is the new India

Indian engineer gets laid off. Boss: “We’re replacing your whole team… with Indians.” Him: “Bro I’m Indian??” Boss: “Nah. Indians from India. Cheaper.” Bro instantly turned into every Indian dad on Earth: “These goddamn Indians are taking our jobs!!” 💀😭 Circle of life hit different 🇮🇳

@TheracelLab if melatonin makes you miserable it's probably from one or more depleted cofactors 🧠 B6, magnesium, zinc, NAD+ or CoQ10 Excess of 90% of the melatonin in your body is created inside mitochondria, it's not just for sleep

"Take your melatonin," they said. "It's natural," they said. A study presented at the American Heart Association's 2025 Scientific Sessions reviewed 5 years of health records for over 130,000 adults with insomnia. Half used melatonin for at least a year. Half didn't. The results: long-term melatonin users had a 90% higher chance of developing heart failure. They were 3.5 times more likely to be hospitalized for it. And twice as likely to die from any cause. The lead researcher said: "Melatonin supplements may not be as harmless as commonly assumed." Here's what bothers me from a metabolic standpoint. Most people taking melatonin nightly aren't dealing with a melatonin deficiency. They have a blood sugar problem. Their liver runs out of glycogen by 2-3am, cortisol and adrenaline spike to compensate, and they wake up wired. Or they're so sympathetically dominant from stress, undereating, or caffeine that their nervous system physically can't switch off. So instead of fixing the metabolic root, they suppress the symptom with a hormone. Nightly & for years. And now we're seeing what happens when you override your own hormonal signaling with exogenous melatonin long-term. This study is observational, but the pattern is hard to ignore. Before reaching for melatonin, try the basics: eat enough during the day so your liver has glycogen at night. Have a snack before bed, milk with honey, fruit with cheese. Get morning sunlight to set your circadian rhythm naturally. Address the stress and the undereating. Let the body make its own melatonin when the conditions are right.

@ThierryBorgeat Too bad nobody is living 300+ years like Duncan McLeod to enjoy this fucking strategy 😆 sometimes waiting in bonds (or metals) is the wise move for BOTH immortals and wage slaves

200 years of investing. One chart. One clear winner. $1 invested in 1801: Stocks: $2,334,920 Bonds: $2,163 Bills: $245 Gold: $4.06 US Dollar: $0.043 Stocks: +6.9% real per year Gold: +0.6% real per year Cash: −1.4% real per year That last one. The US Dollar lost 95% of its purchasing power since 1801. You didn't lose money holding cash. You just transferred it, slowly and quietly, to everyone who owned stocks instead. The most dangerous investment isn't a volatile stock. It's a savings account that feels safe. The chart has been updated 200 times. The conclusion has never changed.