Sergey @ science

835 posts

Sergey @ science

Sergey @ science

@sergey_science

Software engineer and founder with 25+ years of shipping systems end-to-end. Molecular biology, genetics, LLM Pipelines, Agents.

Finland شامل ہوئے Şubat 2023
94 فالونگ55 فالوورز
Sergey @ science ری ٹویٹ کیا
Natalie Wolchover
Natalie Wolchover@nattyover·
Bacteria move around using a molecular machine called the flagellar motor that rotates faster than the flywheel of a race car engine and switches directions in an instant. After 50 yrs, scientists have finally figured out how it works. “My lifelong quest is now fulfilled.” Link⤵️
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Methodical
Methodical@objectextinct·
You can't get protection from any agencies or go public with what you know? I get that you can get sued or whatever but if almost a dozen people are dead and the same people are threatening you ...? Go on CNN or Fox or something. They'd want the exclusive of another testimonial and it puts you too far into the public eye maybe ?
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Beatriz Villarroel
Beatriz Villarroel@DrBeaVillarroel·
Yes, this is real. I also have security-related concerns, and have received a number of unusual approaches, including on flights, about my research.
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Sergey @ science
Sergey @ science@sergey_science·
interesting. Just today I worked with 4.7 High effort whole day, 4 parallel sessions running most of the time and I didn't even hit 5-hours quota. Maybe because I removed all MCP servers and keep skills to the minimum. But I noticed intelligence and speed fluctuates - 10am UTC+3 are the best, and closer to the evening (morning in USA) it gets worse from speed and intelligence POV.
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Serhii Korol
Serhii Korol@ss_korol·
Opus 4.7 xhigh/max effort burns so many tokens... The price is not justified for enterprises. An estimated average for a software engineer who is using Claude Code (not heavily) is $600-800. Management is asking people to save tokens and don't use CC too much. But it defeats the purpose of tight agentic AI integration into all the workflows. And now imagine the level of frustration when the model doesn't even give you what you want for that price. So I'd agree with the comment that enterprise plan is a total disaster.
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Dave Kennedy
Dave Kennedy@HackingDave·
For the enterprises using Claude, if you are using it for heavy enterprise type stuff - be extremely careful. It's introducing massive bugs, security issues, and code quality is way worse than Opus 4.5, substantially worse on both 4.6 and 4.7. Our entire development team is shifting off of it. It's unusable at the moment aside from beautiful UI stuff, it's code quality is not something you can trust. Still no word from Claude on why they mangled their models and didn't tell anyone - which is particularly alarming on every front. I would recommend switching teams over to something like Cursor, Perplexity, or AWS Bedrock - as the frontier models continue to innovate (or regress) - having the ability for flexible model selection that doesn't disrupt development workflow will be insanely important for enterprise.
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Patrick Jackson
Patrick Jackson@PatrickQJackson·
In 2015 - 11 years ago - I figured a way to trigger a response from the Sphere Network’s ultraterrestrial owners to prove to myself that it was real. It is not something I would recommend, but it may explain the disappearance of these scientists and missing hunters. Only now, in 2026, are people openly talking about portals in woodlands, UAP spheres, and the network. #thespherenetwork #uaptwitter #ufotwitter #uap #ufox
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Chris Ramsay
Chris Ramsay@chrisramsay52·
Me when I meet a grey. 👽 This makes more sense if you’ve watched today’s video. But it works either way. Credit: Highstrangeness115 on ig
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Beatriz Villarroel
Beatriz Villarroel@DrBeaVillarroel·
@Zigmanfreud Are you using AI, Mr Ziegler? Do you believe in the existence of artificial intelligence?
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John Ziegler
John Ziegler@Zigmanfreud·
Let me save everyone a lot of time on the UFO/Space aliens issue… It is mathematically/logically impossible for us to have been visited by outside life because we have investigated all the planets close enough for them to have even theoretically left for Earth AFTER we existed!
Rapid Response 47@RapidResponse47

.@POTUS: I recently directed @SecWar to begin releasing government files relating to UFOs and unexplained aerial phenomena. I am pleased to report this process is well underway. We've found many very interesting documents — and the first releases will begin very, very soon. 👽

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Sergey @ science
Sergey @ science@sergey_science·
I wonder why the feedback is so contradictory and inconsistent. Personally, I've experienced both very good thinking of 4.7 even at low effort, and quite bizarre decisions of 4.7 in High effort mode. Feels like there is dependency on time of the day even -maybe inference is controlled by the total load on the system and makes the model dumber "adaptively".
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Rylan Schaeffer
Rylan Schaeffer@RylanSchaeffer·
After 2 days of using Opus 4.7, I can say that this model feels like a step sideways, if not backwards. I've seen it: - regress in its ability to write scientific papers - hallucinate repeatedly - fail to draw basic inferences about what I want It feels different, not better
Jeremy Howard@jeremyphoward

Wow I can already say after just 5 hours using @AnthropicAI Opus 4.7 that this is the first model that "gets" what I'm doing when I'm working. It feels aligned with me in a way no previous model did. (4.6 actively worked against me. I hated it. So this is *very* exciting!)

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Bobby Cooke
Bobby Cooke@0xBoku·
Got cyber approved for @claudeai doesn’t matter, still just shoots down my requests. How lame of @AnthropicAI to shoot down the adversary simulation side of security. Opus 4.6 works but it’s becoming trash and broke several projects this week. Without offensive security, cybersecurity would still be in the Stone Age
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Sergey @ science
Sergey @ science@sergey_science·
@SethSHowes How many read depths did you achieve? but yes, retarded take and written by AI post. If you're not in bioinformatics, chances are, you did it wrong and came to convincing but wrong conclusions.
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Seth Howes
Seth Howes@SethSHowes·
I’ve wanted to do this for a decade. But I never did - I refuse to give any company my DNA. It is me. So this week I sequenced my genome entirely at home. Literally on my kitchen table. I never exposed my DNA sequence to the internet. Not at any point. I used a MinION to do the sequencing (it’s smaller + weighs less than an iPhone). I used open-source DNA models for the analysis (Evo2 and AlphaGenome) running locally on a DGX Spark and Mac Studio. I traced mechanisms behind my family’s multigenerational autoimmune conditions that no clinician has been able to understand. When I set out to do this I didn’t know if it would actually work. It does. Your genome is the most private data you will ever have. You probably shouldn’t let it leave your house.
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Patrick Collison@patrickc

I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!

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johann win
johann win@waejay_·
@sergey_science @jesse_vermeulen i can’t imagine doing my manager’s job of context switching across 8 direct reports and 6 projects, so makes sense why eventually 5 different agents/sessions is hard ¯\_(ツ)_/¯ maybe it’s a learned skill though
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Jesse
Jesse@jesse_vermeulen·
honest question: what do people do during the 5-10 min while Claude is running?
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Sergey @ science
Sergey @ science@sergey_science·
I don't understand why you even started it. 1. Unnecessary costs for GH 2. Unnecessary tokens burned/electricity/fossil fuel 3. Unnecessary attention grab from all here Is it supposed to be fun or what? Sounds like irresponsible thing to do. If you have extra tokens that you don't know where to put, I will gladly accept them to build a genetic tool, for example.
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Josh Cohenzadeh
Josh Cohenzadeh@jshchnz·
With my codemaxxed project surpassing 353,000,000 lines of code (not a typo) I actually got a @Github cease & desist 🪦 "We've noticed that the repository is growing fast while committing very frequently. This looks like some sort of automated activity that serves no purpose."
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johann win
johann win@waejay_·
when you drift away to do something else, it leads to more context switch, which leads to more context switch, which makes it harder to stay in deep work mode, so i just started intentionally doing absolutely nothing. it gives my brain time to think alongside claude
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Sergey @ science
Sergey @ science@sergey_science·
Felix, I’m worried you got an ill culture of daily shipping. People are reporting lots of issues. If I were a product manager in your team, I would pull emergency stop lever and focus on bug-free releases. With such high pace you are heading towards low reputation. I’m honestly concerned.
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Felix Rieseberg
Felix Rieseberg@felixrieseberg·
We ship new little improvements every single day, but this one was requested so much that I'm tweeting about it: Skip all permissions for Claude Cowork. Use with care, brought to you by @dreamofabear
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🪓 CyberAxe (Jeremy Benisek) 🪓
🪓 CyberAxe (Jeremy Benisek) 🪓@cyberaxe·
@ClaudeDevs Assholes. You disgust us. I hope you get sued, you abuse your customers then call it a bug. You full well know you're doing this on purpose. You lie more than Claude does.
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ClaudeDevs
ClaudeDevs@ClaudeDevs·
We fixed a bug where rate limits on Claude subscriptions weren't properly adjusted for long context requests in Opus 4.7. We've reset 5-hour and weekly rate limits. Enjoy Opus 4.7!
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Sergey @ science
Sergey @ science@sergey_science·
@caleb_kinmon @bcherny @firstadopter I don’t have that poor experience. Used 4.7 at low effort setting and shipped three changes in my work. Honestly, I saw no regression on 4.7 so far. But I did see them in 4.6 and 4.5.
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tae kim
tae kim@firstadopter·
Anthropic running out of compute is hurting their brand among customers. Honestly? We're paying customers. We deserve the service (and reliability uptime!) we paid for.
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Sergey @ science
Sergey @ science@sergey_science·
@RayFernando1337 You probably need to go back to basics: threaten it, say you have no hands and blind, and promise billions in rewards if it thinks hard :)
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Ray Fernando
Ray Fernando@RayFernando1337·
Wait, what happened to the Extended Thinking toggle on Opus 4.7? Opened Claude this morning and the toggle I use every day is gone. It's now "Adaptive thinking, thinks only when needed." Dug into the docs and on 4.7, adaptive is the only mode. The model decides per-request if it wants to think or not. Where is the way to force it on? What does this mean for a Max user like me who lives on the phone and web (not Claude Code or the API)? On 4.6, Extended Thinking on meant every answer got the deep reasoning. I pay $200/month for Max and I kept it on for my workflows, projects, etc. On 4.7, every request kind of feels like a slot machine. Did the model think about this one? Is my request worthy enough of more thinking? What if I tell it to think harder...ultrathink...mega ultra uber giga think?? I don't know. Pull the lever and just...hope? When it does more thinking with 4.7 it is a nice experience and I love what the team built. Just wondering out loud if there's a way for $200 Max user to force thinking on every request. Happy to pay for it. Anyone else notice this?
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