Charles Leduc, MD

@angelpanizo1 @ariella8 @nucleololailo @RunjanChetty @DraEosina @Mvgs1706 @drtimbracey @SingJamieD @GIJamesMD @Vik_deshpandeMD @CArnold_GI @DrMarkOng @vi_monappa That is fascinating and an excellent lesson in scrutiny and objective observation! Thank you for sharing.

@ariella8 @nucleololailo @RunjanChetty @DraEosina @Mvgs1706 @drtimbracey @SingJamieD @GIJamesMD @Vik_deshpandeMD @CArnold_GI @DrMarkOng @vi_monappa The history of Congo red‐stained amyloid is an example of how an erroneous belief can become widely established even when it is contradicted by simple experience: "Congo red‐stained amyloid just shows “apple‐green birefringence" (PMID: 31515863) ncbi.nlm.nih.gov/pmc/articles/P…

#GIPath #Colonicpolyps not #Orise I was thinking I am joining the #Orise club but seems I am not 😆. @RunjanChetty Sigmoid colon polyp 6 mm in diameter Besides doing congo red, what would be your workup of this case and formulated comment for the clinician,if amyloid proved

Hi all! So we all know about constrictive bronchiolitis, but can it happen in large airways? Below is post-SBRT obliterative bronchitis of LLL with secondary necrotizing granulomatous consolidation - awaiting stains but betting on NTM. A sort of (non) middle lobe syndrome!

Do you recognize these seed-derived storage cells (images courtesy of @oreoimc)? See the latest publication on these cells and the lesions they produce co-authored by me, @Histopatolomon. and @navale_pooja at rdcu.be/cz4ZC. A Twitter inspired collaboration.

@yro854 @oreoimc @Histopatolomon @navale_pooja Fascinating article. I love the comparative histology. Thanks for this work and for sharing the link!

@smlungpathguy The nested appearance of those cells is odd - any history?

Hemochromatosis or nah?

@QiWang54691035 @Andy_pathology Agrees if this is primary !

@Andy_pathology Pulmonary blastoma?

Lung, your view?

Bag of worms. Hydrophilic polymer embolisation with secondary thrombosis. This is a thrombectomy specimen from the right femoral artery in a patient undergoing peripheral vascular surgery. The guidewires are coated in this material that can occasionally embolize. Yikes!

Thanks to all who engaged! Although uncommon, chronic LCH can lead to severe secondary pulmonary HTN which is what we see here. A spectrum of arterial lesions, including plexiform, dilatation, and medial hypertrophy. Wishing the patient a new lease on life with new lungs!

Explants from woman in her mid 40s. Clinical history on req: pulmonary hypertension. IHC is CD1a. Unifying diagnosis?

@yro854 Indeed classic LCH, advanced. Must say that image in isolation could indeed be a recanalized thrombus but overall it just looks like a constellation of arterial lesions within the spectrum of non-thombotic HTN, secondary to underlying lung disease. I'll share more images.

@thoracicpath Langerhans cell histiocytosis and a recanalized artery, probably a late stage of pulmonary thromboembolism. Awaiting revelation of the relationship, if any, between both lesions.

@WRPears @yro854 No doubt that is the underlying caus. LCH with secondary pulmonary HTN.

@Steve1walker Nailed it! Thanks for engaging.

@thoracicpath LCH causing pHTN. Trial of smoking cessation in first instance.

@kolesliemd Right on - thanks for participating!

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#Pulmpath #Thoracicpath #Pathbugs Excited to share unusual case ,Male 60s ,3.8 cm lung mass ,Bx sent as suspected malignancy ,look at the first set ,try to make the Dx ,then go to second set

@mreyesm Very sad news. A giant in our field. I feel honoured to have met him

We have lost a giant of #Pathology and #LungPath #PulmonaryPath. Dr. Sam Yousem, an admired colleague and friend died yesterday. He will be missed and remembered.

Barcelona hospital performs first successful transplant on patient with Covid-ravaged lungs in Spain catalannews.com/covid-19/item/… vía @catalannews @vallhebron @ThoracicSurgHVH

- Lung development stage? Canalicular Lung (16-25 WGA) - Is it perinatal pneumonia? Aspirated amniotic exudate - What are placental findings? Acute Necrotizing Chorioamnionitis with Funisitis #placenta #perinatal (😬 I forgot @basophil_brett) 🥇@leon_metlay 🥈@grenierkarlMD