Conrad Johnson

@CasPiancey Because of this guy: @mqudsi . Check out his current PDF attachment work, if you haven't already.

@BagMan31814 @ItalianPointers @FCNightingale You're describing Houston, good sir. We make chips and missiles and Internet here in Dallas.

@ItalianPointers @FCNightingale Oil and gas market is in the tank.. Houston and Dallas need oil above $80/ barrel

Austin, Texas Office vacancy rate is 29%. Inventory 67,628,079 SF Sublet Vacant 3,347,986 SF Direct Vacant 16,285,346 SF Industrial vacancy rate is 21.9% Inventory 100,577,445 SF Overall vacant 22,025,908 SF Multifamily vacancy rate is 14.3% Stabilized vacancy rate is 10.2% "Austin, Texas, wins the dubious distinction of the softest rental market in the nation, with the median rent there down 6.3% from the year before." - CNBC -Cushman and Wakefield #CommercialRealEstate

@higherconnecti3 @BellamSwathi @bryan_johnson "bro...we gotta measure again in 30 days... To make sure this ain't temporary..."

I think magic mushrooms are a longevity therapy. After seeing the data from two doses, psilocybin offers unique longevity effects that complement the best performing therapies I’ve done to date including sauna, hyperbaric oxygen therapy, sleep, nutrition and exercise. This was the most quantified psychedelic experiment ever done. It's noteworthy that even though many of my biomarkers are already in the 99th percentile optimal, psilocybin still showed multi-system improvements. Something other therapies have not been able to accomplish. Of course, my data will need to be replicated and the magnitude and duration of benefits needs further assessment. Here is what we learned: 0. We observed broad benefits across mental, hormonal, metabolic, and anti-inflammatory systems. Since these are the primary drivers of biological aging, this multi-system signal offers a compelling case for longevity potential. 1. Psilocybin may be a metabolic reset button for the brain. We expected brain changes, but not a potential metabolic breakthrough. My blood sugar control improved from the top 2% of the population to 0.2%, better than 99.75% of 18-25 year olds. 2. Psilocybin reduced my inflammation (hsCRP) to below detectable levels one week post dose. 3. Psilocybin calmed my body and mind.  Lower cortisol, and an inhibited HPA-axis in the days following the dose. Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery. 4. Psilocybin increased brain plasticity, desynchronized default networks, resulting in enhanced creativity, playfulness, and openness, with reduced mental rigidity. 5. A second psilocybin dose built on the first and pushed sensory integration even further, increasing primary sensory-motor integration beyond the peak of the first dose. 6. Psilocybin induced an intense blend of joy, deep insight, and a subtle hint of melancholy,  also detectable by thermal biometrics. We had two significant firsts in this experiment: 0. First documented human CGM-based observation of improved post-psilocybin glucose control. 1. First-ever thermal profile of an intense psilocybin dose. Pending data: + Telomere length and relative telomerase activity (telomere regeneration capacity). + Epigenetic measurements + Microbiome Experiment details Here are more details about my two magic mushrooms trips, doses, and the results of my measurements up to date. I had two doses of dried and powdered Psilocybe Cubensis (Variety  B+) mushrooms, three weeks apart. First dose Nov 9th: 4.67g (24.98 mg psilocybin and 3.5 mg psilocin). Setting: relatively private, only with @_katetolo and the accompanying guide. Second dose Nov 30th: 5.35 g (28 mg psilocybin and 4 mg psilocin). Setting: relatively open, with friends and family joining virtually, and live streaming. I dissolved the first dose in orange juice but used lemon juice for the second, for the following reasons: + Lemon is more sour, which delays the conversion to psilocin and breakdown in solution, thus preserving more total psilocybin to be activated to psilocin after ingestion. + Lemon juice has, on average, 70% less sugar and 45% less calories, making it less disruptive to my otherwise faster state throughout the journey, and leading to a much lower glucose peak. Rewired brain connectivity Kernel Flow measurements after the first dose showed shifts in my brain connectivity mirroring my subjective experience, and the mapping of 5-HT2A receptors. These included the inhibition of my default networks and command centers including prefrontal context and a shift towards increased functional connectivity and hyperintegration between primary motor, sensory, auditory, and speech integration. This coincided with an entropic brain pattern, more open, flexible, exploratory, and creative, indicating a shift from aged and rigid to open youthful brain state. The baseline measurement before the 2nd dose indicated a strong lasting effect from the first dose 3 weeks earlier, post-peak measurement after the 2nd dose indicated an additive effect of the 2nd dose, with a brain entropic and increased primary sensory-motor integration beyond the peak of the first dose. Most notable was the increased intensity of integration and activation of the auditory, speech, and language networks, coinciding with the second dose being joined by family, friends, where I enjoyed expressing and describing my feelings. Face and body thermal biometrics We produced the first ever face and upper body thermal map of a magic mushroom journey. A core temperature increase of 1.5–2°F suggests an intense psychedelic experience, likely due to a large psilocybin dose (28 mg psilocybin, 32 mg combined psychoactive content). Heat was redistributed to the core, consistent with 5HT2A–mediated autonomic activation, which can include increased sympathetic tone, lasting through the peak and early post-peak of the experience. Facial and body thermal shifts indicate a potential blend of intense joy, insight, and subtle sadness or melancholy. First documented human CGM-based observation of improved post-psilocybin glucose control Psilocybin appears to have triggered a previously unknown metabolic reset in my brain, an unexpected breakthrough.  Comparing the 3-day periods before and after the psilocybin dose: My blood glucose control dramatically improved, moving from the top 2% to the top 0.2% of the entire population, including healthy 18-25 year olds. + 8% reduction in mean blood glucose, reaching 80.84 mg/dL, a new personal best. + 11% reduction in fluctuation, indicating smoother glucose peaks and improved control. + This single session reduced my estimated HbA1c 0.3 6.8% from 4.7% to 4.4%, (a relative reduction of 6.8%). + Durability: The positive effect was still as strong on Day 3 post-dose as it was on Day 1. Note: A long trip to China on Day 4 interrupted this streak. We plan to explore the full durability of this effect with the next dose. This matters because we treat diabetes and metabolic dysfunction with chronic daily medication (Metformin, Insulin, GLP-1s). This data suggests that a neuroplastic event might have downstream effects on the liver and pancreas that mimic or exceed these drugs. Systemic inflammation was below detectable levels Five days after the first dose, my hsCRP dropped to an undetectable level (below 0.15 mg/dL), representing a 35-100% decrease from the pre-dose level of 0.23 mg/dL. Three days post-second dose, hsCRP was barely detectable at 0.18 mg/dL, which is still a 22% drop from the initial baseline. Tumor necrosis factor-alpha (TNF-alpha) remained unchanged between baseline and post-second dose. It was not measured after the first dose. For the next dose, we will measure a wider panel of inflammatory markers, including IL-6 and IL-10, and cover several time points post-dose. High cortisol at Peak, low cortisol and stress the following week Cortisol spiked at the peak of the acute phase, followed by a decline in morning cortisol levels and HPA-axis inhibition, consistent with a relaxed "after-glow" phase in the week following the trip. My cortisol spiked to 3x morning spike levels four hours after taking the mushroom dose. Levels returned to normal nightly baseline before bedtime. Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity. Estradiol levels increased by 200%, consistent with preliminary published evidence that peripheral 5HT2A activation increases cortisol by driving aromatase expression.

@Mawuko @evabeylin Almost as if.... That was the roadmap since 2017. You speak like roll ups invented Ethereum, and not the truth which is the other way around.

@evabeylin the best thing rollups did for ethereum was buy it time for ethereum mainnet to figure itself out by receiving the redirected traffic intended for ethereum's mainnet. x.com/Mawuko/status/…

my favorite thing about this is it's not intellectually honest the main reason gas is cheap now is bc most transactions are now on L2s, even with block size increase if all transactions moved back to L1, gas would still likely be more expensive than on L2s

@0xWiz_ @josephdelong pragma solidity 0.4.10.lolol

@ConradJohnson @josephdelong that was funny :D

I have yet to meet one person who thinks inheritance should be removed from Solidity. Some people drown so remove all water type sh*t

@josephdelong Best I can do is one Hudson and I have already shown you in 2016 without inheritance: github.com/Oaken-Innovati…

@ConradJohnson Show me a contract you’ve built using only composition

@davehonig @stoolpresidente The other point is the only other score you made that same game. Plastic.

@ConradJohnson @stoolpresidente And buckeyes covered every game except for one What’s your point ? Buckeyes will win by 14+

This is for Ohio fans eyes only. I need to know before we really get into this rivalry week. Are you guys gonna say the game doesn’t matter after you lose like your coach did last year? #askohiofans

@davehonig @stoolpresidente What's also beautiful is Aggies are going to walk in to Texas stadium, beat them at home, a full day before you play, just to show you your team is spray paint and duct tape before you get schooled by Michigan.

@davehonig @stoolpresidente You've played nobody entire season, except Texas, at home, and barely won by a touchdown.

@BryceWeiner Well ... the bots fucked them. Amiright?

“I work for Panaltir” has never gotten anyone laid. Prove me wrong.

Incel mouth breather has opinions.

@grok @MaalEduardo @SariArhoHavren Could you also provide the same US projections for 2150 and 2200 like you did with China and put those side by side (US/China) population projections?

US crude birth rate (per 1,000 people): 11.0 in 2020, 10.6 in 2021, 10.7 in 2022, 10.7 in 2023, and ~10.6 in 2024 based on ~3.6 million births against ~348 million population. Total fertility rate sits at ~1.6, below the 2.1 replacement level but cushioned by a younger demographic structure than China's. Without net migration, US population may peak near 370 million by the 2040s before easing to ~340 million by 2050 and ~300 million by 2100, per Census/UN low-migration models accounting for natural decrease momentum.

Chinese state media has called the US a failed state, claiming it is “dying from within” as its global power wanes. This commentary, published in Beijing Daily, came as Chinese policymakers prepare long-term plans amid escalating competition with Washington during a crucial four-day conclave that began Monday. 1/2

@grok @MaalEduardo @SariArhoHavren Now do United States @grok . Same parameters with current US birth rate and population.

Yes, unchecked trends suggest steeper declines post-2100, with models extrapolating from UN data implying 300-500 million by 2150 and under 200 million by 2200, as shrinking cohorts compound. Mitigation via aggressive pronatalism, AI-driven productivity, or controlled immigration could blunt this, though cultural resistance and policy inertia pose hurdles. China's scale amplifies risks, but adaptive tech might sustain influence despite depopulation.

@Parsley3D @nixorokish @ethereumfndn He's dusting. Stop simping

@nixorokish @ethereumfndn Insane posture for the seat on our friend at the head of the table He's defeated the shrimping

@evan_van_ness @tayvano_ <--

Why are you, as an intelligent human being, still using MetaMask in the year of our Lord 2025?

@cryptocomicon @adamscochran ^

@adamscochran Alternatively, it serves the DoD's interest to have people believe that they may have this.

1/6 It’s been almost a year since Grusch testified before Congress explicitly stating: -He was informed of crash retrieval programs. -Money being siphoned from the government. -The US had UAP craft. -He had first hand knowledge of people who had worked on that. And while AARO & the DoD denied the claims one interesting thing stands out: -Neither the DoJ nor AARO have requested a perjury case against Grusch.

@EthereumDenver Spork

First 500 to say “Spork” 👇

@cyb3rshi3ld Hi

F*CK IT sending more study guides and practice dumps to everyone who says 'hi' 🛡️ Happy Friday ‼️ (must be following, so we can DM)

I contributed to the MACI v2 Trusted Setup Ceremony! You can view the steps to contribute here: ceremony.pse.dev You can view my attestation here: gist.github.com/conradjohnson/…