Matt Mulè

384 posts

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Matt Mulè

Matt Mulè

@MPMule

https://t.co/k3jnFRIRuM | human immunology | PhD from @Cambridge_Uni / NIH @NIHOxCam. MD student @UNC_SOM

Tham gia Ekim 2014
854 Đang theo dõi455 Người theo dõi
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Jonathan Pritchard
Jonathan Pritchard@jkpritch·
Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵
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Masato OGISHI
Masato OGISHI@MasatoOgishi·
1/ We report @ImmunityCP that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner. cell.com/immunity/abstr…
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Matt Mulè
Matt Mulè@MPMule·
Imagine a patient at initial presentation with an immune-mediated disease; rather than focusing on tissue/antibody-based diagnosis, you treat based on a test that captures the patient's global immune health. Another great step in that direction from my colleagues @tsanglab
John Tsang @tsanglab.bsky.social@TsangLab

1/12 Check out this paper that came out last week from our pan-monogenic project, which utilizes diverse natural single-gene defects in humans to study and assess the immune health of both patients with disease or those clinically healthy. nature.com/articles/s4159…

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James Lee
James Lee@Dr_James_Lee·
There's been amazing coverage of our new paper @Nature nature.com/articles/s4158… but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...
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Fermat's Library
Fermat's Library@fermatslibrary·
Sir Francis Galton on the Central Limit Theorem
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Matt Mulè
Matt Mulè@MPMule·
More of Sarah's nature/biology inspired art books, prints and design work: designhops.com
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Matt Mulè
Matt Mulè@MPMule·
It's so meaningful to share this chapter of work with my colleagues @TsangLab with my wife Sarah, who created the cover for @ImmunityCP. Days spent working together while in grad / art school, overlooking our garden in Cambridge, were some of the happiest in my life :) 1/
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Immunity@ImmunityCP

New issue online! Cover depicts work from @TsangLab & @MPMule &co identifying a "naturally adjuvanted" state in individuals who respond more robustly to unadjuvanted vaccines. Artwork by Sarah Hopkins cell.com/immunity/issue…

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Immunity
Immunity@ImmunityCP·
New issue online! Cover depicts work from @TsangLab & @MPMule &co identifying a "naturally adjuvanted" state in individuals who respond more robustly to unadjuvanted vaccines. Artwork by Sarah Hopkins cell.com/immunity/issue…
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Mauro Corrado
Mauro Corrado@MauroCorradoBio·
Immunology Twitter, I need your help. I am looking for a scRNAseq dataset for mouse ILCs (if gut specific even better). Can someone highlight some reference?
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ton rabelink
ton rabelink@RabelinkT·
Using spatial metabolic flux we identified the conditions to preserve discarded human donor kidney’s for at least 4 days ex vivo. Such an approach also holds the potential for resuscitation and could increase the window for organ allocation. rdcu.be/dHL6W
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John Tsang @tsanglab.bsky.social
John Tsang @tsanglab.bsky.social@TsangLab·
Our paper @ImmunityCP reveals a human baseline setpoint state (ie, "temperature" under which immune responses are initiated) linked to better responses to flu vaccination resembles cell states induced early and uniquely by the AS03 adjuvant. 1/n
Matt Mulè@MPMule

Our paper "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint" @TsangLab is now online @ImmunityCP Link to open access pdf: authors.elsevier.com/c/1j0dm3qNrUxt…

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Khám phá

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