Ross Wilson

I’m excited to share our report - out now in @natBME - of a new approach to CRISPR delivery that is poised to transform the way engineered T cell therapies are manufactured. Visit tinyurl.com/CRISPR-PERC for “how to” details. It’s threadin’ time! (1/11) nature.com/articles/s4155…

🧬 Can CRISPR dial down α-synuclein instead of knocking it out? MTI winners Ross Wilson & Hanqin Li aim to halt Lewy bodies with precision base editing - $90 K + full platform support. #CRISPR #Parkinsons #MTIAwards 🔗 Read more at moleculartherapeutics.org/2026-mti-parki…

Inaugural post! (after a long hiatus) Last May I quit my job to build @dittobio with @Mezarque and @emilycpierce ! We turn parasite molecules into drugs for autoimmune disease, and are part of the @ycombinator W26 batch. Thanks for betting on us @agupta

@Nicole_Paulk Nearly an hour? Tons of time to spare! 😅

We got our 941 page GLP toxicology pig study report back with 54 minutes to spare to make the 2 week SEND dataset file conversion cutoff for our Dec 23 IND submission!!!!!!

@MartinPacesa Thanks, Martin!

@RossWilsonLab Wow, really cool Ross!

Big news! Our team developed Neuro-PERC, a non-viral CRISPR delivery platform for genome editing of the brain. In our new preprint - bit.ly/NeuroPERC_pre - we report efficient editing in multiple models & species, including field-first results in large animals (pigs) 🧵👇

@jacksonlab @Mizzou Huge credit to @BrigetteManohar for leading this collaborative effort based at IGI & @berkeleyMCB, which would have been impossible without major contributions from OSU's @TNeuroSci_Lab @RussellLonser and support from NIH's SCGE consortium @somaticediting

@jacksonlab @Mizzou Together, these findings establish Neuro-PERC as a versatile, scalable, well-tolerated platform… as well as a promising candidate for clinical translation in neurotherapeutics. 🐭🐷🧠🧬✂️

@ScotWolfe1 @danielevanbauer @srishtiupasana Thanks to @GENbio for putting together a nice write-up on this work, which is available here: bit.ly/GEN-hiNLS We put our two favorite hiNLS constructs on @Addgene for anyone interested in giving them a try: addgene.org/search/catalog…

@ScotWolfe1 @danielevanbauer What did we see? • hiNLS constructs supported high yields • hiNLS can improve genome editing efficiency • this was true via 2 delivery methods: electroporation & PERC (peptide-mediated) • more NLS is better, but only up to a point Credit to T cell editor @srishtiupasana!

Cas9 gets an upgrade! Check out our new paper in The CRISPR Journal: bit.ly/hiNLS-Cas9 Eric Noel (who is on the job market!) created Cas9 constructs w/ nuclear localization signals (NLS) in the backbone, boosting genome editing activity in T cells. #CRISPR

New Strategy Enhances CRISPR Editing Efficiency for Therapeutic Use In a new April 2025 @CRISPRjournal published study, IGI @UCBerkeley researchers leverage new constructs for NLS sequences to improve editing efficiency in human immune cells #crispr hubs.li/Q03hZVqv0

@GENbio @CRISPRjournal @UCBerkeley Thank you for the lovely write-up!