Longevity Foresight

4/4 The Ultimate Question: Why live longer? Not to prolong anxiety, but as Dr. Conti says: To weave peace, contentment, and the capacity for delight into our lives—even knowing life's tragedies—and wanting to live it over and over again. ✨ True longevity is reclaiming absolute agency over how you experience life.

3/ Reclaim Agency from "Micro-Inertias" Are you staying up late by choice, or is inertia dragging you? Reclaiming control doesn't require a "total rebirth tomorrow." 💡 Tactical downgrade: Design one micro-step today that you absolutely cannot fail. Prove to your brain that you still hold the steering wheel.🛞

Taking top-tier longevity supplements but constantly attacking yourself in your head? You're missing the ultimate biomarker of healthspan: Psychological Agency. ❤️ In the latest @hubermanlab , DrPaulConti reveals the hidden truth of anti-aging: Supplements can't fix internal burnout. Change starts with rewriting your inner script. 🧵

@stats_feed However, the growth of healthy life expectancy is significantly slower; in the future, anti-aging efforts should focus on extending the period of good health.

Global life expectancy: 1900: 32 years. 2025: 73 years.   We doubled human lifespan in 125 years.   The most underrated stat in history.

Sinclair is back! @davidasinclair Podcast Lifespan is on season 2 m.youtube.com/watch?v=rXLCug…

@biogerontology May good luck favor us.🙏

My AI just analyzed the data from all super centenarians (>110 yo) and found the most important common feature that drove that extreme longevity. They did not exercise, diet, or sleep. They were all very lucky. Luck is the ultimate geroprotector, my friends.

@rand_longevity Optimizing mitochondrial function can reduce the aforementioned risks.

you need to avoid these 4 if you want to live a long life - cancer - dementia - heart disease - diabetes

This is what 97 years of biological decay looks like in one minute. We've mapped the human genome, landed rovers on Mars, built AI that writes poetry. We still accept this as normal. It doesn't have to be.

@chiidex27 It is true that she runs and does Pilates every day, but the light-based treatments and growth hormone supplements are the real hidden variables?

ngl kim kardashian's longevity needs to be studied for real

@rand_longevity Strength training is the closest thing to a longevity drug we have ever found.👀

do you focus on cardio or lifting?

3/3 Backed by titans like Peter Thiel, this profit-driven scheme is being disguised as "bodily autonomy." This isn't a sports revolution; it's a stress test on society's bottom line. The real crisis: When chemical "enhancement" becomes a hidden baseline for workplace and social competition, can you afford to stay "natural"?

2/ So, capital wrote the perfect 3-step commercial script: 1️⃣The Game: Pay athletes to break world records using peptides and steroids under "medical supervision." 2️⃣The Endorsement: Use these records to tell the world these banned substances are actually safe and effective. 3️⃣The Sale: Launch a platform to sell the exact same drugs to ordinary people terrified of aging.

.$1.2B valuation. 50 athletes allowed to take any drugs they want to compete. 🧗 The @enhanced_games opening in Vegas this month looks like a sports rebellion against anti-doping rules, but it’s actually the most expensive product launch in history. Longevity capital has finally found the ultimate fast-track to bypass clinical trials and dump anti-aging drugs on the mass market. 🧵👇

@Outdoctrination So fat storage could be a survival signal, not just a bug?

Calorie restriction can increase lifespan by ~40% - but a stunning study showed that it's NOT because of fat loss or insulin sensitivity. In fact, the animals who were the fattest actually lived the longest! (🧵1/8):

@forallcurious but how do we avoid cancer?

🚨: Researchers managed to reverse the biological age of human skin cells by up to 30 years, effectively turning 53-year-old cells into 23-year-old cells, through a technique called partial cellular reprogramming.

First drug ever shown to lengthen telomeres in a randomized trial. Henagliflozin, a diabetes drug, for 26 weeks. Results: - Treatment group: 90.5% had longer telomeres - Placebo group: 65.6% - Difference: statistically significant, p<0.01 This isn't a supplement study with 12 people. It's a randomized placebo-controlled trial of a drug millions already take for blood sugar. Telomere shortening is one of the 12 hallmarks of aging. Every decade, your telomeres lose about 14% of their length. This is the first time a pill has reversed that trajectory in a controlled experiment. SGLT2 inhibitors already extend life in heart failure patients. Now we might know one reason why.

@beffjezos details pls🤔

AI just upgraded the human genome, increasing our healthspan 5x