Jun Qi Lab

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Jun Qi Lab

Jun Qi Lab

@JunQiLab

Chemical Biology lab @HarvardMed and @DanaFarber. We use a multidisciplinary approach to study biological roles of epigenetic proteins & transcription factors.

Boston, MA انضم Aralık 2018
417 يتبع1.6K المتابعون
Jun Qi Lab
Jun Qi Lab@JunQiLab·
@sciqst @MolMetab Yes, with the multiple targets and pathways we identified, they are all can be targets for novel therapy development.
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Raffaele Di Giacomo, PhD
Raffaele Di Giacomo, PhD@sciqst·
Congratulations on the publication, it's intriguing to see histone acetylation taking a central role in energy storage regulation. How do you think these insights might affect therapeutic approaches for metabolic disorders? Could this lead to potential biomarkers for disease states based on acetylation profiles? Both "active" and "passive" acetylation balancing mechanisms seem like an intricate dance, potentially opening novel avenues in epigenetic therapy. For more in-depth discussions and to explore further biomedical reviews, Sci-Quest offers an excellent platform at sciqst.com. #Epigenetics #Medicine
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Jun Qi Lab
Jun Qi Lab@JunQiLab·
Our collaborative study with Dr. Qiong Duan on histone acetylation regulated energy storage is now published @MolMetab. We established more understanding on how "active" acetylation vs "passive" acetylation balanced each other at different states. molecularmetabolism.com/article/33284/…
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Jun Qi Lab
Jun Qi Lab@JunQiLab·
Thank you @StBaldricks for highlight our research on studying natural compound in DMG with Prof. Movassaghi @ChemistryMIT and @FilbinMariella. Thank you so much for your support @StBaldricks
St. Baldrick's Foundation@StBaldricks

Hope is powerful. Research is lifesaving. 🙏 Your support helps fund groundbreaking discoveries for children battling cancer. Read how it’s making a difference in our latest edition of Research Outcomes: ow.ly/sNel50YhTUk

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Jun Qi Lab
Jun Qi Lab@JunQiLab·
With better understanding of proteosome machinery, hopefully, we can come up more and more cool idea to utilize the system for novel therapy development.
Dana-Farber News@DanaFarberNews

New research in @angew_chem by @DanaFarber’s @JunQiLab reveals a novel chemical biology approach to achieving selective targeted protein degradation using proteosome cap region proteins directly in addition to the current PROTAC strategy, which could aid in developing therapies and cancer drugs. ➡️ bit.ly/4rbilu9

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Jun Qi Lab
Jun Qi Lab@JunQiLab·
Our work using cap region proteins of proteosome to directly induce targeted protein degradation is now published online @angew_chem. Congratulations to all the authors on bringing this to the finish line. Thanks @BloodCancerUtd for supporting our work. doi.org/10.1002/anie.2…
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Jun Qi Lab
Jun Qi Lab@JunQiLab·
We would like to thank the support from @EpendymomaRF, @curingkidsckc and @StBaldricks that allow us to build our biology capability to explore novel therapeutic options for pediatric brain cancer.
Jun Qi Lab@JunQiLab

Our collaborative work with Prof. Mo Movassaghi at @chemistryMIT and @FilbinMariella is now online @acsJACS @ACSPublications. Thrilled to work as chemical biology part to explore therapeutic potential of these awesome nature compounds from Mo's lab. pubs.acs.org/doi/10.1021/ja…

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Jun Qi Lab
Jun Qi Lab@JunQiLab·
I am thrilled to work and publish together with my postdoc PI, Prof. Mo Movassaghi @ChemistryMIT to bring their sophisticated chemistry to potential therapy development. I am excited to keep learning from Mo and @FilbinMariella. Pic from: news.mit.edu
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Jun Qi Lab
Jun Qi Lab@JunQiLab·
It is so exciting to see the final version of our collaborative work with @LabSethi. We found that blocking HDAC1/2 pushes CRC cells out of a stem-like state and into differentiation. We will work tother more to find novel therapeutic options for CRC. authors.elsevier.com/c/1m7oK3mEmnPKi
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Jun Qi Lab
Jun Qi Lab@JunQiLab·
@LabSethi it is a true pleasure to work with you and your team.
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Sethi_Lab
Sethi_Lab@LabSethi·
A great collaboration with my friend @JunQiLab. We screened a small molecule library targeting epigenetic regulators curated by Jun’s team using our dual reporter system. The ensuing mechanistic work required innovative chemical and rigorous molecular biology.
Dana-Farber News@DanaFarberNews

Proof-of-concept: Epigenetic reprogramming could one day be a new therapeutic path in colorectal cancer. @Nilay_Sethi explains how histone acetylation shapes CRC cell fate in this @AGA_Gastro study: bit.ly/46gS7z1

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Jun Qi Lab
Jun Qi Lab@JunQiLab·
It is so exciting to see our collaborative work with @Nilay_Sethi is now available online. My team and I are always eager to learn more about novel therapy development for CRC together with Nilay and his wonderful team!!!
Dana-Farber News@DanaFarberNews

Proof-of-concept: Epigenetic reprogramming could one day be a new therapeutic path in colorectal cancer. @Nilay_Sethi explains how histone acetylation shapes CRC cell fate in this @AGA_Gastro study: bit.ly/46gS7z1

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Jun Qi Lab
Jun Qi Lab@JunQiLab·
It is awesome to have JQ-WON team to build a boat and get first place in the boat building competition at ⁦@DFCI_ChemBio⁩ retreat!!!! Awesome design, decoration, ride, and teamwork!
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Jun Qi Lab
Jun Qi Lab@JunQiLab·
@StBaldricks There might be some challenging time in the life. You will and can go through it with your braveness, love and support. Keep your wonderful smile and best of luck.
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St. Baldrick's Foundation
St. Baldrick's Foundation@StBaldricks·
Lucas was diagnosed with high-risk ALL in 2023 after what seemed like growing pains. He’s endured intense treatment but remains “everyone’s friend,” spreading kindness & joy. His final chemo dose is set for July 2025. 💛 Drop words of encouragement below as he continues to fight.
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اكتشف

@sciqst @MolMetab @StBaldricks @ChemistryMIT @FilbinMariella @PennMedicine @junwei_s @LilingWanLab