Picotti Lab

Thank you European Proteomics Association for the JPA Proteome Pioneer Award in recognition for our group's work in this field. The award promotes "the principles of sharing and integrating resources for the development of excellent research" which is something we do strive for.

Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out @NatureBiotech ! Read here👉: doi.org/10.1038/s41587… 🔬 Highlights: - Uses an experimental library of peptide markers integrated with a structural proteomics workflow. - Probes the assembly state of hundreds of protein complexes simultaneously across conditions directly from whole cell extracts, informing on binding interface occupancy. - Supports the structural modelling of protein complexes and the design of compounds targeting them Congratulations to shared first authors @CathyMarulli and Christian Dörig and thanks to our collaborators @LabBarral and @TorstenSchwede lab @ETH_en #Proteomics #PPIs #SystemsBiology #LiPMS #teammspec #DrugDiscovery

@labs_mann @ETH_en heinekenprizes.org/2024/06/11/rue…

We are proud to announce that Ruedi Aebersold, founder of our institute and beloved colleague, will be awarded the Dr H.P. Heineken Prize for Biochemistry & Biophysics 2024. He receives it together with @labs_mann for their groundbreaking contributions to proteomics @ETH_en

We found novel candidate interactors for the monomeric and amyloid fibrillar forms of #AlphaSynuclein and for different conformational states of Rab GTPases. A great collaboration with the @pedrobeltrao, @KorkhovLab Roland Riek and Sean Munro groups.

Our paper describing a method to screen for conformation-specific protein-protein interactions is out @MolSystBiol. Read it here: doi.org/10.1038/s44320… The approach can also be used to map interaction sites. @IMSB_ETH @ETH @ETH_en #proteomics #massspectrometry #interactomes

Congratulations, Albert. An exciting research area you are pioneering. We look forward to exciting discoveries ahead.

High resolution protein complex analysis beyond AP-MS by the Gstaiger group: nature.com/articles/s4159…. Nice collaborative adventure at @IMSB_ETH from the @MGstaigerlab members @FabianFrommelt , @anfossati , @federico_uliana and from @bwollsch lab members

Exciting development for 🇨🇭 research! Following a three-year hiatus, scientists from Switzerland can now participate in the 2024 ERC Advanced Grants. The ETH Board wishes that this solution can be extended to all 2025 calls in summer 2024. #HorizonEurope

Publication by the Allain & Leitner Labs (@IMSB_ETH, @ETH_en) with 1st authors Tebbe de Vries & Mihajlo Novakovic (@tflut1,@Mehighlow993) "Specific #protein-#RNA interactions are mostly preserved in biomolecular #condensates" @ScienceAdvances bit.ly/4cfo0sb #MS #LLPS

N&V by @seth_margolis on the study by @Picotti_Lab & @MichalSharon3 developing an advanced #proteomics method (PiP-MS) to comprehensively explore 20S #proteasome substrates in the human proteome ➡️ embopress.org/doi/full/10.10…

Our warmest congratulations to Franziska Elsaesser on the successful defense of her PhD. Excellent job, Franzi!

Great talk by Tetiana Serdiuk at the AD/PD conference on biochemical differences between amyloid strains linked to different alpha-synucleinopathies. @adpdnet

This study is the result of an excellent collaboration with the @wolfgangkhuber lab, @ArosioLab_ETH, @EWB_Lab, @BrittaVelten lab and @HeatherDMaynard lab! @IMSB_ETH @ETH @ETH_en @embl #proteomics #massspectrometry #proteinstability #osmolytes

We also learned about the thermal behavior of intrinsically disordered proteins. Many predicted disordered regions may fold in situ!

Our paper on the mechanisms of protein thermal stabilization by osmolytes is out @nchembio. We found that osmolytes thermally stabilize many proteins in situ using various mechanisms (but there's a dominant one – read the paper to find out). Read it here: nature.com/articles/s4158…

The paper by @KorkhovLab, together with @Picotti_Lab, Alexander Leitner and @federico_uliana, now out in @emboreports, describes the cryo-EM- and structural proteomics-based analysis of adenylyl cyclase AC8 and its macromolecular complexes. More: biol.ethz.ch/en/news-and-ev…

So happy to see our work published at @CellCellPress ! We added the quaternary structure dimension to proteome-wide, #AlphaFold2 predictions: The published paper: sciencedirect.com/science/articl… The original 🧵 (Two more experimental structures since!) x.com/ElevyLab/statu…

A systematic investigation of 20S #proteasome substrates reveals 100s of substrates & differential functionality of naïve and oxidized 20S proteasome complexes ➡️ embopress.org/doi/full/10.10… @Picotti_Lab @IMSB_ETH @MichalSharon3 @WeizmannScience #proteomics #massspectrometry

Our paper with @MichalSharon3 is now live @MolSystBiol. We identified hundreds of substrates of the 20S proteasome, enriched in RNA- and DNA-binding proteins with IDRs. A variety of substrates showed site-specific cleavage, suggesting functional products. embopress.org/doi/full/10.10…