Roy

🚀 Excited to share our latest research on metabolomic signatures of carfilzomib-related cardiotoxicity in multiple myeloma patients, highlighting our newly developed risk score! #CardioOncology #Research Our study investigates the endothelial dysfunction in patients undergoing carfilzomib treatment, focusing on creating a predictive risk score for cardiovascular adverse events (CVAE). #EndothelialDysfunction We found that lower levels of protective biomarker T-UDCA in patients who developed CVAE could indicate a predisposition to these adverse events. This finding was crucial in developing our risk score. #Biomarkers #CVAE By analyzing post-baseline/baseline ratios of metabolites, we identified key differences in dihydroxybenzoate, GCDCA, and ferulic acid between CVAE and non-CVAE patients. These metabolites are integral to our risk score. #Metabolomics Our risk score incorporates the levels of these metabolites, providing a quantifiable measure to predict the likelihood of CVAE in patients undergoing carfilzomib treatment. #RiskScore #PredictiveModeling Dihydroxybenzoate, known for its cardioprotective properties, plays a significant role in our risk score, linking metabolomic changes to potential cardiovascular risks. #Cardioprotection The risk score also considers the beneficial roles of T-UDCA, statins, and regular exercise in reducing CVAE, emphasizing the importance of preventive strategies in high-risk patients. #CardioHealth #PreventiveCare By integrating these factors, our risk score offers a personalized approach to predicting and mitigating cardiovascular risks, enhancing patient care and outcomes. #PersonalizedMedicine #CardioOncology Our research contributes to a better understanding of the mechanisms behind carfilzomib-related cardiotoxicity and provides a practical tool for clinicians to assess and manage these risks. #CancerTherapy #RiskAssessment 🔍 Dive into the full study for a comprehensive look at our methodology, detailed findings, and the development of our risk score: pubmed.ncbi.nlm.nih.gov/38783568/ #ResearchPublication #Science

US: assassinates Iran’s entire leadership Iran: fine, then you can pay to pass through the Strait of Hormuz US: BuT tHaT’s aGaInSt iNtErNaTiOnAl LaW edition.cnn.com/2026/03/28/mid…

@FranciscoPoleoR It’s not a deliberate conspiracy, it’s dysfunction and engineering challenges/ competing priorities.

Miami urgently needs to invest in mass transit if they’re serious about becoming the next great metropolis in the country. But that clashes with the people who actually run the city because they own the political system: the big car dealers and the developers who build the infrastructure for those cars.

@thebenchesclear Until they have enough data to convince Bo he should DH, this is the plan.

they’re actually committing to DHing brett baty

“An analysis by the Florida Policy Institute found that Florida would have to double its sales tax to 12% to replace lost property tax revenue. The move would make the state sales tax the nation's highest.” yahoo.com/news/articles/…

@TennisGuy_31 Actually he was on deck

Meanwhile Lindor is hanging with his bitch wife and Mamdani lol

This is one of the most perfect things the internet has ever created.

The CPAC crowd cheered after Matt Schlapp asked if they’d like to see Trump subjected to impeachment hearings. Follow: @AFpost

@ArthurMacwaters @ycombinator Let’s go boys!

AI medicine is inevitable. In fact, it has arrived. We're excited about this agreement with Utah to allow our AI to prescribe psychiatric renewals. Yes. AI prescribing medication. This is monumental and will collapse the cost of care. (1/

Artificial intelligence will see you now: Bots to prescribe mental health drugs trib.al/89qtnNz

@JeremyRedfernFL @RonDeSantis If one race needs a score on average 35% less than another race, controlling for every other variable, that is defacto race-based discrimination and we can objectively conclude this and monitor it over time.

@RonDeSantis It’s the same “scientific authority” that is teaching future physicians about how males can become females through puberty blockers, hormone replacement therapy, and mutilating surgeries. Many of these institutions are run by people who reject the existence of objective truth.

The “heart of scientific authority” where objective measures are disregarded in favor of ideology and social activism in their discriminatory admissions policies?

@LooksmaxMe Crimemaxing

Clavicular was arrested for assault last night. This is his mugshot.

@KingstonBooke @Clavicular0 Jay Collins is not mad about the alligator. He is mad Clavicular still has a hairline

BREAKING: Florida Lieutenant Governor Jay Collins demands @Clavicular0 “face charges” for shooting dead alligator.

We live in a constant cycle where Trump screws everything up all week and then returns to thunderous applause at Mar-a-Lago in order to get recharged to do it all over again the following week

Today the FDA approved the first once-weekly insulin. Insulin icodec, now brand name Awiqli, demonstrated superior a1c reduction to daily insulin glargine with a1c reduction of 1.55% compared to 1.35%, in addition to 6 less injections per week in the ONWARDS phase 3 trial. Now clinicians must become comfortable with switching daily insulin users to an equivalent weekly dose and start and titrate new users. novonordisk-us.com/media/news-arc…

I agree, and I welcome the discussion. What is the medical rationale for routinely obtaining X-rays in healthy, asymptomatic patients who are simply presenting for an annual cleaning? In what other area of medicine are healthy people exposed to imaging on a routine annual basis without symptoms or a specific clinical indication?

@Rwill235 @LarryGreer20 @ATabarrok I refuse yearly x rays and have been doing every 2 years. I have not found great evidence to support yearly X-rays when asymptomatic and I think there are some risks to the radiation . Would love to see anyone with a complete analysis of risks and benefits of dental X-rays

Went to the dentist for a cleaning. Refused the blood pressure check, refused redundant x-rays, refused to sign a waiver for refusing the x-rays. Three nos to get one teeth cleaning. I am now known as a troublemaker.

@LarryGreer20 @ATabarrok You can start with this meta analysis and work your way from there. It’s not hard. pubmed.ncbi.nlm.nih.gov/31502516/?utm_…

@Rwill235 @ATabarrok Bullshit.

If you have the basic skills to participate in the discourse at all — like you can read and comprehend a New York Times article in order to complain about it — you’re in a weird, out of touch, elite bubble. slowboring.com/p/in-defense-o…

@scalingself_ @hubermanlab They don’t. No long term safety data, not FDA approved in most cases.

@hubermanlab If your a young male, training 3-5x a week, taking common (useful) supps (creatine, omega 3’s, D3, magnesium etc), sleeping well, are peptides worth it? when do they become worth it?

Prediction: the peptides that will hit the broader male and female HRT space next are kisspeptin and gonadorelin (and not in place of HCG!). Will be interesting to see which companies compound for wide distribution first. These are potent and MD monitoring will be key.