JDL™

@sircalebhammer ENVIRONMENTALISTS. RUIN. EVERYTHING.

Bro, this state can’t be real

Every time you get a cancer biopsy, the lab makes a tissue slide that costs about $5. It shows the shape of your cells under a microscope, and every cancer patient already has one on file. There’s a much fancier version of that test called multiplex immunofluorescence (basically a protein-level map showing which immune cells are near your tumor and what they’re doing). It costs thousands of dollars per sample, takes specialized equipment most hospitals don’t have, and barely scales. But it’s the kind of data oncologists need to figure out whether immunotherapy will actually work for you. Right now, only about 20 to 40% of cancer patients respond to immunotherapy, and one of the biggest reasons is that doctors can’t easily tell whether a tumor is “hot” (immune cells actively fighting it) or “cold” (immune system ignoring it). Microsoft, Providence Health, and the University of Washington trained an AI to analyze the $5 slide and predict what the expensive test would show across 21 different protein markers. They called it GigaTIME, trained it on 40 million cells in which both the cheap slide and the expensive test coexisted, and then turned it loose on 14,256 real cancer patients across 51 hospitals in 7 US states. The results landed in Cell, one of the most selective journals in biology. The model generated about 300,000 virtual protein maps covering 24 cancer types and 306 subtypes. It found 1,234 real, verified connections between immune cell behavior, genetic mutations, tumor staging, and patient survival that were previously invisible at this scale. When they tested it against a completely separate database of 10,200 cancer patients, the results matched up almost perfectly (0.88 out of 1.0 agreement). Nature Methods named spatial proteomics (mapping where specific proteins sit inside your tissue) its Method of the Year in 2024, and specifically cited GigaTIME in a March 2026 update as a model that “democratizes” this kind of analysis. The full model is open-source on Hugging Face. Any cancer research lab with archived biopsy slides, and most of them have thousands, can now run virtual immune profiling without buying a single piece of new equipment.

@theREALcman1 @Blatantendo @GeeQueNYC @Faydster @TheMetsX Y'all retards have really convinced yourselves that people on the right are all Klan members, never having had an actual conversation w anyone actually on the right. Shut the fuck up. Your idea of who your political opposition is, is a demented fantasy. Absolutely pathetic.

@Blatantendo @GeeQueNYC @Faydster @TheMetsX Ahhh so now u care about black people 😭😭😭

Clowns, like yourself, genuinely just omit the fact that the United States of America having the greatest military on the face of the planet award us freedoms that we don't even realize that we have. These people risk their lives so we have the comfort of living in peace. There are so many countries around the globe that not only don't have basic freedoms like we do, but that also have to head inside bomb shelters at all hours of the day and act like it's normal. On behalf of all rational Americans that understand how privileged we are to live inside this country and support the men and women that allow us those freedoms, kindly shut the fuck up Linda. 🇺🇸

Somewhere, a Warren staffer is drafting a memo about how 'abundos' are pushing 'dangerous deregulation' that will kill everyone who even looks at an elevator. They're drafting a bill to go back to manual elevator operation, proclaiming it adds 'good-paying union jobs'.

Nothing says "Manufacturing Golden Age" like a 363% increase in the price of aluminum.

@eroscestlavie_x x.com/i/status/20313… Blue states really, really seem to want to accelerate this phenomenon.

One of those screenshots I think everyone needs to stare at before reading one of those salary articles. I constantly have to mentally adjust to it because I grew up thinking of $70k as the target "good" salary and $100k as wild wealth. But the 70k I used to think of is now 100k.

@LinkofSunshine x.com/i/status/20313… Meanwhile, in Europe

Huh

The Jones Act has 4 requirements: Vessels must be U.S. built. Vessels must be U.S. owned. Vessels must be U.S. crewed. Vessels must be U.S. flagged. The crippling part of the Jones Act is that U.S.-built U.S. shipyards, for a variety of reasons, are incredibly inefficient. We don't have that many of them, and they cost about five times what a ship from South Korea would cost. As a person who actually believes in trade, I fully would love for South Korea to become our US shipyard. We just buy ships from them because they're good at making them. Coastal water transport in the U.S. could be 60% cheaper. Because of the Jones Act, it's actually cheaper to ship goods from the U.S. to a foreign country and back to the U.S. than between two ports, which is completely bonkers insane! As a byproduct, we have killed all of the growth within the Mississippi, which should be the most powerful inland economic advantage in the world. Maintaining the requirement of U.S.-owned, U.S.-crewed, and U.S.-flagged is perfectly fine and in line with my general national security concerns, but U.S.-built has destroyed our shipping industry. There's tens of billions of GDP lying on the table here, and a direct step in reducing our dependency on foreign suppliers. It's also how you kickstart rebuilding an American shipyard industry. If you 10x the number of U.S. ships working in ports, you start building all of the maintenance businesses at U.S. ports, and the demand increases. The U.S. bill requirement of the Jones Act is horrifically destructive to America and, in particular, horrifically destructive to middle America, and it should be destroyed.

Ironically, he is the reason as to why every subsequent president has had to.

@TheIllegit Lmao

And it was installed (checks notes) in 1935, a mere 150 years after the founding of the country.

@Dontskylertalk @25YearsAgoLive You can't afford universal healthcare, and if any of the countries that do have it had the taxes that fund it abolished for a couple months, they'd all revolt upon their reinstatement.

Senior citizens at the Bonne Bell factory in Lakewood, Ohio assemble cosmetics for $7.50/hr. The seniors work to help pay increased healthcare costs that come with their age.

@MSFoxPro9 @Type07Safety Please explain to the group why people who have a hobby which does not involve harming anyone should go to jail over it.

@Type07Safety Why should they. Why does he need guns, why does anyone need guns? We have very very small murder rate from guns in the UK, in fact we have a very small murder rate. Period. 28 recorded homicide victims killed by shooting in England and Wales in 2022. 28!

Man caught with his dad's old rifle "capable of firing bullets" is jailed. Is there any country weaker and more pathetic than the UK? We, The People, are so glad we divorced you in 1776 and we're never going back.

this wasn't contagion we built a system where identifying as LGBT gave you protected status, social capital, media representation, and institutional preference. the superior class par excellence. no one in american history had more unearned systemic privilege than the alphabet people, and it's not a shock that teenagers adopted it. they were adapting to the incentives. what we are seeing now is a return to normalcy since the incentives have been removed

Threw a boomerang into the kitchen thinking it might bring me back a drink or something like that but it mostly just broke a lot of stuff in there

@goatpurple1 @CTourtellotte I'm just confused about what the deal with these hideous stacks of shoeboxes is tbh. I mean, is it in service of a floor plan? Is it zoning laws? It can't possibly be cheaper to build these with random edges and cubes jutting out like that.

@acceleratingJoe @CTourtellotte All buildings in US post 1945 are ugly City rules just make it worse

“Sign here to reduce traffic,” they said. NIMBY’s went door to door collecting signatures to overturn our 573 unit project. They got enough signatures. But… it was thrown out on a technicality (they didn’t attach entire DA). Today, hundreds of families have a place to live.

dostoevsky said if you gave people everything they wanted, cakes, entertainment and nothing to worry about except the continuation of the species, they’d start breaking things out of boredom he was right we got comfortable enough that people started manufacturing their own suffering and building identities around the invented problem, to the point where mutilation is seen as healthcare. because a life without struggle felt like a life without meaning. the idea of being broken gave them something to solve and someone to fight, an identity and a sense of community but, once the problem gets “solved” nothing changes, obviously. the emptiness was there before the “problem” (it’s always there), and it’ll be there after. the cause of the problem is never fixed these people never wanted to be fixed, they wanted to feel special

@Logically_JC -top income tax bracket of 47.5% -25% VAT/sales tax And when it comes to the paid parental leave thing, turns out Norway has a lower birth rate than the US. Americans who stan these policies have no idea what they'd look like in practice,&if they did, they wouldn't support them.

This one hits hard.

"40% of the cost of a new home is gov't regulations. If you require min lot sizes & large setbacks, you have to put big houses on big lots & they're more difficult to afford... We got rid of min lot sizes... we allow duplexes anywhere you can put a single family." @GovGianforte