Amanda Wiggenhorn

Hello world! We are FAST (Future Advancers in Science & Technology). We build programs where scientist mentors work with students from under-resourced high schools on research projects based on students’ own passions & curiosities - inventing or discovering something new! (1/4)

My lab is recruiting a postdoc fellow to characterize new biochemical pathways that control taurine and glucose metabolism. Email me at wei.wei2@wisc.edu to apply! Please help RT🙏 @longlabstanford @JudithSimcox @UWBiochem

Sharing our latest review on peptide hormones by Laetitia Coassolo @Laeti67202 and Amanda Wiggenhorn @AmandaWigg_ in Trends in Biochemical Sciences @TrendsBiochem @StanfordPath Free full text: sciencedirect.com/science/articl…

So excited for you and your future work! Congrats!!

Today in @Nature, we share our latest paper. We developed an algorithm to predict novel peptides cleaved by proconvertases across all human tissues. Using this method, we identified BRP, a brain-derived anti-obesity peptide. nature.com/articles/s4158…

Amazing work lead by Laetitia! Congrats! Super cool story highlighting a new signaling peptide!

Our new paper in Cell Systems demonstrates how AlphaFold can predict the binding between ligands and cell surface receptors. Congrats @nbds_bio and co-authors from K.C. Garcia lab See paper here: cell.com/cell-systems/a… @StanfordPath @StanfordDRC

Really excited to share our recent discovery of a novel pathway of B-hydroxybutyrate metabolism linked to energy balance! Thanks to @longlabstanford and all collaborators! biorxiv.org/content/10.110…

From @mariadolores_mg, we dive into the biochemistry and physiology of ketosis- and show that the metabolic pathways of BHB extend beyond primary metabolism to include bioactive secondary ketone metabolites @WuTsaiAlliance @Stanford_ChEMH @StanfordPath

Today in @NatureComms we describe the role of SLC17A1/3 in urine Lac-Phe efflux. The surprisingly insight that unlocked this pathway? Lac-Phe mis-assignment to “1-carboxyethyl phenylalanine” @Metabolon. Congratulations @veronical1411 @Stanford_ChEMH nature.com/articles/s4146…

I'm excited to share our latest collaboration with @fidocklab using mixed alkyl/aryl phosphonates to identify possible drug targets in Plasmodium. Our work offers a possible method for deciphering important drug targets, mechanism of action, and mechanisms of resistance.

Our paper using mixed alkyl aryl phosphonates to identify serine hydrolases in Plasmodium falciparum that are potential drug targets is out. Great work from @ChemBio_John and collaborations with @fidocklab. Free Download here -authors.elsevier.com/a/1jarB8jWWJxM… cell.com/cell-chemical-…

Today in @nature, we discover a new enzyme in mammalian taurine metabolism- and uncover a chemical connection between diet, genetics, and body weight. Congrats @WeiWei_Stanford @Stanford_ChEMH @StanfordPath @mfgrp @cholsoon_jang @SvenssonLab @Lingyin_Lab nature.com/articles/s4158…

@Zhi_Lindsey_Lin @ScienceMagazine @realJimWells Congrats! Great work!

Thrilled to share our MultiMap paper is now published online on Science. @ScienceMagazine With @realJimWells, we present a multiscale photocatalytic proximity labeling platform for interactome profiling. science.org/doi/10.1126/sc…

Congratulations to @AmandaWigg_ and @veronical1411, the newest 2024 PhD graduates of @StanfordUChem @StanfordMed @Stanford_ChEMH We are all very proud of both of you. Congratulations and job well done 🎉🎉

Congratulations to our very own Dr @AmandaWigg_ on a successful thesis defense!!! Great talk and well done @Stanford_ChEMH @StanfordUChem @StanfordPath

Excited to be at ⁦@BrainResilience⁩ symposium today!! Check out ⁦@skxiao_nju⁩ poster number 42, about metformin, exercise, and gut brain crosstalk ⁦@Stanford_ChEMH⁩ ⁦@StanfordBrain⁩

Here we show that prior to 2022, the metabolite Lac-Phe was mis-annotated in @Metabolon datasets as “1-carboxyethylphenylalanine.” We use this information to identify physiologic urine Lac-Phe transporters. Incredible detective work by @veronical1411 biorxiv.org/content/10.110…

Fearless and prolific, @WeiWei_Stanford is at it again- this time connecting an enigmatic branch of taurine metabolism to body weight control. Congratulations to all, and extra thx to our dear collaborators @mfgrp @SvenssonLab @cholsoon_jang @Stanford_ChEMH @StanfordPath