Lingyin Li Lab

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Lingyin Li Lab

Lingyin Li Lab

@Lingyin_Lab

The lab of chemical immunology 🧬 🧫 💊 🐀 Student-run account by lab of @li_lingyin

Katılım Ağustos 2022
52 Takip Edilen208 Takipçiler
Lingyin Li Lab
Lingyin Li Lab@Lingyin_Lab·
🚨New cGAMP transporter just dropped🚨 Check out the latest preprint from the lab, led by grad student Valentino implicating SLC7A1 as the dominant cGAMP transporter in T cells biorxiv.org/content/10.110…
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Annemarthe Van der Veen
Annemarthe Van der Veen@VanderveenLab·
Such an honour and pleasure to host @Lingyin_Lab in Leiden last Friday on the occasion of the 10th ICI symposium of @ICI_NL. Fabulous talk on STING signalling and oligomerisation, PTMs, ENPP1 and ENPP3!
Annemarthe Van der Veen tweet mediaAnnemarthe Van der Veen tweet mediaAnnemarthe Van der Veen tweet media
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Lingyin Li Lab
Lingyin Li Lab@Lingyin_Lab·
Congratulations Dr. Chris Ritchie on new work defining PELI2 as a negative regulator of STING, now published @MolecularCell! Read the paper here: cell.com/molecular-cell…
Arc Institute@arcinstitute

🎧 Exciting new discovery from @li_lingyin and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling headphones for the cGAS-STING pathway. cGAS-STING is a crucial immune defense mechanism for the human body that’s triggered in response to threats like viral and bacterial infections and cancer. But how does it know when to fight and when to stand down? Lingyin and Chris found that PELI2 acts like a sensor, filtering out cellular “white noise” that could chronically trigger STING—and lead to inflammatory conditions like lupus and neurodegeneration. At the same time, PELI2 turns into an amplifier when interferon levels grow above a certain threshold, ensuring that STING turns on at the right time.

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Lingyin Li Lab
Lingyin Li Lab@Lingyin_Lab·
Check out the lab's discovery of the newest player in cancer immunotherapy! Lead author and protein biochemistry expert @rmardj is also on the job market for those in search of all-around brilliance!
Arc Institute@arcinstitute

⚡After discovering the role of the ENPP1 enzyme in masking cancer from the immune system, @Lingyin_Lab has found a new enzyme, ENPP3, that also inhibits cGAMP-STING signal + anti-tumor immune response, preventing immunotherapies like Keytruda from working effectively. 🧵⬇️

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Lingyin Li Lab
Lingyin Li Lab@Lingyin_Lab·
Read this amazing perspective from our fearless leader looking back at the work that started it all and forward to all that's to come in cancer innate immunotherapy!!
Lingyin Li, PhD@li_lingyin

It is a great honor to participate in Cell Chemical biology’s special issue focusing on Inflammasomes and Immunoregulation to celebrate the 30th anniversary of the journal in 2024. Also celebrating 10 years of ENPP1 and extracellular cGAMP. authors.elsevier.com/a/1j3578jWWJxL…

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Rafa Pinilla-Redondo
Rafa Pinilla-Redondo@rafapinilla92·
How do phages/MGEs overcome bacterial defenses? Delve into our @NatureRevGenet review on 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝗼𝗿𝘀 𝗼𝗳 𝗯𝗮𝗰𝘁𝗲𝗿𝗶𝗮𝗹 𝗶𝗺𝗺𝘂𝗻𝗶𝘁𝘆!🛡️ We discuss discovery methods, classify mechanisms, & examine their biotech potential!🧬 nature.com/articles/s4157… 1/11
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Andy Posbe
Andy Posbe@adnroide·
I'm happy to share ColabFold-Pipeline-Toolkit, an easy recipe book put together to help streamline the use of ColabFold for newcomers without a computing background who want to perform high-throughput screens with ColabFold BATCH. 🧵 github.com/andyposbe/Cola…
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Lingyin Li Lab
Lingyin Li Lab@Lingyin_Lab·
We are so proud of MD-PhD student and food enthusiast @SongnanWang for her exciting new work characterizing ENPP1 as an innate immune checkpoint for breast cancer! Biggest congratulations to Songnan and coauthors @alby_joseph13 @VSudaryo
Arc Institute@arcinstitute

Breast cancer is 1 of the deadliest cancers for women, but <20% respond well to immunotherapy. New research in @PNAS from Arc Investigator and @Stanford Biochem Prof @li_lingyin + @Stanford grad student Songnan Wang uncovers why. bit.ly/48q50EN 🧵

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Lingyin Li Lab
Lingyin Li Lab@Lingyin_Lab·
Follow (the real) Lingyin and check out new preprint! In short, superstars @rjchan426 and @xujun_cao dig deep into what it takes to activate STING and the best therapeutic strategy to inhibit STING signaling!
Lingyin Li, PhD@li_lingyin

My former account was compromised. If you find me here somehow, please add me back to your circle. This article proves that this is the real Lingyin Li and I am not trying to sell you crypto. If you still do not believe me, AMA about STING and cGAMP. biorxiv.org/content/10.110…

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Lingyin Li Lab
Lingyin Li Lab@Lingyin_Lab·
Congratulations Dr. Rachel Mardjuki!! Rachel is a protein purification pro and a singing superstar. So proud of you @rmardj!
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Axel R. Concepcion
Axel R. Concepcion@AxelRConcepcio1·
Don't miss the seminar by prof. Lingyin Li from @Lingyin_Lab @StanfordBiochem this Wednesday at 11am EST: "Extracellular cGAMP signaling in health & Disease" You can tune in on zoom: nyulangone.zoom.us/j/95442008054?… +Info: ictiseminars.com Please share!
Axel R. Concepcion@AxelRConcepcio1

📢Our next speaker in The Ion Channels & Transporters in Immunity Seminar Series will be prof. Lingyin Li from @Lingyin_Lab @StanfordBiochem on April 19. Dr. Li will talk about “Extracellular cGAMP signaling in health & disease". Zoom link👇🏼 nyulangone.zoom.us/j/95442008054?… Please share!

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Lingyin Li Lab
Lingyin Li Lab@Lingyin_Lab·
Celebrated lab achievements over mini golf! Labs that putt-putt together, stay together! ⛳️
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Keşfet

@LanT_763 @chembioBryan @Nature @Stanford_ChEMH @StanfordPath @mfgrp @cholsoon_jang @SvenssonLab