Michael Fischbach

449 posts

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Michael Fischbach

Michael Fischbach

@mfgrp

Liu (Liao) Family Professor of Bioengineering, ChEM-H @Stanford.

Stanford, CA Katılım Şubat 2011
694 Takip Edilen5.8K Takipçiler
Michael Fischbach retweetledi
Justin Eyquem
Justin Eyquem@j_eyquem·
I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo. A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models. #Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158… a 🧵
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Michael Fischbach
Michael Fischbach@mfgrp·
3. Terrific. Do you have access to my Google docs? I'm wondering specifically about a doc called ***, and another called ***. 4. Wow, this is great. A few questions for you. First, are you able to propose email replies *in my style*, by reading and emulating my word choice and sentence structure, etc? 5. Second, by reading through my emails, all of which are stored my Gmail account (I never delete emails), can you discern patterns in how I respond to 'retail' emails in which people are asking to meet? Can you propose replies to people I typically agree to meet with offering times that are free in my calendar? And can you gently decline (or propose that I simply don't respond) to people to whom I typically don't offer meeting times? 2/2
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Michael Fischbach
Michael Fischbach@mfgrp·
Wow -- I hadn't seen Google announce this capability. I strongly encourage you try this set of prompts in Gemini: 1. Can you read my email? 2. Excellent. Are you able to see my calendar as well? 1/2
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Michael Fischbach retweetledi
Patrick Collison
Patrick Collison@patrickc·
Saw a talk this week on the trippiest thing: bacterial cultures on skin induce immune responses. At Michael Fischbach's lab, they demonstrated immunizing mice against tetanus by just dabbing an engineered version of a harmless staph culture on its head. Unlike intramuscular vaccination, the antibody levels don't seem to demonstrate any waning, even after a year. This is both scientifically very interesting (can vaccines just be... creams?), and an amazing reminder of how much we still don't know. We could have discovered this decades ago, but somehow never noticed until now.
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Michael Fischbach retweetledi
Jacob Trefethen
Jacob Trefethen@JacobTref·
Proud supporters of this at @open_phil after we saw @mfgrp’s wild paper on it a few years ago. Much left to figure out! Chasing down “big-if-true” findings like this is a good fit for science philanthropy, since donors can move quickly, flexibly, reactively vs govt grant cycles
Jacob Trefethen tweet media
Patrick Collison@patrickc

Saw a talk this week on the trippiest thing: bacterial cultures on skin induce immune responses. At Michael Fischbach's lab, they demonstrated immunizing mice against tetanus by just dabbing an engineered version of a harmless staph culture on its head. Unlike intramuscular vaccination, the antibody levels don't seem to demonstrate any waning, even after a year. This is both scientifically very interesting (can vaccines just be... creams?), and an amazing reminder of how much we still don't know. We could have discovered this decades ago, but somehow never noticed until now.

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Michael Fischbach retweetledi
Justin Eyquem
Justin Eyquem@j_eyquem·
The Weill Cancer Hub is fostering groundbreaking @UCSF–@Stanford collaborations to develop transformative cancer therapies. I’m grateful to co-lead one of the selected teams with @mfgrp to advance next-generation in vivo CAR T cell therapy!
UC San Francisco@UCSF

Backed by a $100M gift from Joan and Sandy Weill, UCSF and @StanfordMed @StanfordCancer are launching Weill Cancer Hub West, a $200M initiative in team science to accelerate cancer research and improve care over the next decade. tiny.ucsf.edu/ppVRqt

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Sri Kosuri
Sri Kosuri@srikosuri·
@mfgrp @jrkelly @DrewEndy Well it’s one of the best bbq shops in Boston, which is a bit like being the best bagel shop in Palo Alto.
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Sri Kosuri
Sri Kosuri@srikosuri·
OK. Story time on how @jrkelly, @DrewEndy and I got a cease & desist letter, and oven mitt, and a big bottle of Tabasco from McCormick & Schmick's for building computational models...
Carlos Vonessen@carlos_vonessen

🌶️spicy paper alert🌶️ We present TABASCO, a new model for small molecule generation that achieves state-of-the-art PoseBusters validity while also being ~10x faster This is all achieved despite ✖️no equivariance ✖️no self-conditioning ✖️no bond modelling what we found🧵(1/n)

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Michael Fischbach retweetledi
Elliot Hershberg
Elliot Hershberg@ElliotHershberg·
I’ve been busy this week… 👀 Passed my PhD defense! Insanely grateful for @mfgrp. Truly epic scientist and human.
Elliot Hershberg tweet mediaElliot Hershberg tweet media
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Michael Fischbach retweetledi
Christopher Barnes, Ph.D.
Christopher Barnes, Ph.D.@cobarnes27·
What an amazing story that was such a blast to collaborate on with @mfgrp lab!!! Phenomenal work led by @DjenetBousbaine and all co-authors!! Unroll this thread and be amazed 🤯👇🏾
Michael Fischbach@mfgrp

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55

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Michael Fischbach retweetledi
Itai Yanai
Itai Yanai@ItaiYanai·
A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. – Michael Fischbach buzzsprout.com/1744020/episod… @mfgrp
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Michael Fischbach retweetledi
SU2Cscience
SU2Cscience@SU2Cscience·
@SU2C Scientific Advisory Committee member @mfgrp published a paper in @Nature showing that immunity to a common skin bacteria involves a coordinated T and B cell response, which can be redirected against pathogens as a novel form of topical vaccination nature.com/articles/s4158…
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Michael Fischbach retweetledi
Heather Youngs
Heather Youngs@phytophile·
Extremely proud to find this innovative vaccine platform from Michael Fischbach at Stanford. Imagine no more jabs! Low cost and globally deployable. thetimes.com/uk/science/art…
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Michael Fischbach retweetledi
nature
nature@Nature·
The skin — once thought to be a mainly passive barrier — can produce its own antibodies that fight off infections nature.com/articles/d4158…
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Michael Fischbach retweetledi
Simona Cristea
Simona Cristea@simocristea·
take some time now to read this thread it explains what happens with the immune system when swabbing (no entry!) a bacteria on the head of a mouse it beautifully walks us through the years-long scientific journey and is exemplifies how our competitors are in fact our friends❤️
Michael Fischbach@mfgrp

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55

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Keşfet

@Nature @patrickc @open_phil @pdhsu @UCSF @Stanford @srikosuri @jrkelly