Mark Leick

26 posts

Mark Leick

@Mark_Leick

MD | Assistant Professor at HMS | MGH Bone Marrow Transplantation and Cellular Therapy | Leick Lab | @OslerHousestaff 2014-2017

Boston, MA Beigetreten Aralık 2016

123 Folgt256 Follower

Mark Leick retweetet

Bryan D. Choi MD PhD@BryanDChoi·14 Mar

Today, @NEJM published our clinical study of a novel #CARTCell in patients with #Glioblastoma. Early results with CARv3-TEAM-E suggest safety and bioactivity. Special thanks to all collaborators @MGHNeurosurg and @MGHCancerCenter! nej.md/3VnjUIq

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Eli Darnell, MD@EliDarnellMD·14 Mar

nejm.org/doi/full/10.10… Amazing findings coming out of the Maus lab! Great step forward to GBM treatment. Congrats to all the authors on their incredible work.

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Majzner_Lab@Majzner_Lab·31 Tem

Excited to share that @Majzner_Lab is moving to @DanaFarber @DFBC_PedCare as of Sept. Bittersweet to leave Stanford, but looking forward to growing our research program both in the lab and in the clinic. Hiring postdocs, scientists & lab manager- please reach out if interested!

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Klebanoff_Lab@KlebanoffLab·15 Haz

🚨Next-level T cell engineering enters the clinic! DNA base editor to simultaneously silence CD7 (minimize fratricide), TCRB (minimize GVHD), and CD52 (host pre-conditioning) in allo CD7 CAR-expressing T cells for T-ALL. No DNA cuts, no translocations. nejm.org/doi/full/10.10…

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Majzner_Lab@Majzner_Lab·6 Nis

Really happy to see the wonderful work from colleagues in Rome using 3rd gen GD2 CARs for neuroblastoma. This is the largest series of CAR T responses in a solid tumor to date & the fact that it’s in a pediatric cancer is awesome! Bravo! nejm.org/doi/full/10.10…

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Mark Leick@Mark_Leick·19 Mar

CAR-T coming for a non-malignant indication near you thelancet.com/journals/lance….

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Majzner_Lab@Majzner_Lab·9 Mar

Happy to share the newest paper from our lab. Led by technician extraordinaire Aidan Tousley (soon to be an MD/PHD student!), this manuscript details our attempts to reimagine the structure of CARs to improve their specificity and efficacy. rdcu.be/c7avS

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NatureRevClinOncol@NatRevClinOncol·16 Şub

'Multiomics STEP up in correlative analysis of response to CAR T cells'. In this article, Mark Leick & Marcela Maus discuss the potential of cfDNA-based analyses to inform on CAR T cell expansion kinetics & tumour-infiltration patterns in patients: nature.com/articles/s4157…

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Nathan Singh@NathanSinghLab·25 Oca

We are hiring! Interested in engineering, genomics and T cell therapies for cancer? Want to work with awesome people? Looking for a great place to live? Come join us in St Louis! More info about us here: sites.wustl.edu/nathansinghlab/ Apply here: wustl.wd1.myworkdayjobs.com/en-US/External… Please RT!

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Michael Jain@MichaelDJain·11 Ara

Great talk on germline HLH variants affecting CAR-T toxicity by @Mark_Leick @MarcelaMaus , looking forward to collaborating! #ASH22 @DrFredLocke

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Mark Leick@Mark_Leick·10 Ara

Hope you picked up your badge at the airport… 😬#ASH22

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Frederick L. Locke@DrFredLocke·10 Ara

If you assumed we are talking about CAR-T, you would be correct! @jaepark @MarcelaMaus @Mark_Leick #ASH22

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Saheli Sadanand@SaheliSadanand·10 Kas

Thoughtful piece in @NatureMedicine from @Eddie_Cliff, Reid Merryman, Philippe Armand and Caron Jacobson @harvardmed @DanaFarber on #CARTcells in #DLBCL. Thanks for writing this! #lymphoma #lymsm

Eddie Cliff@Eddie_Cliff

Our commentary in @NatureMedicine addresses 3 critical unanswered questions in the use of 2L CAR-T for DLBCL: 1) How to approach patients w chemo-sensitive disease? 2) Bridging therapy & 3) cost. Would love to hear your thoughts (no paywall): rdcu.be/cZfkl #lymsm

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Nick Vitanza@VitanzaNick·19 Eki

We're excited to share the 1st clinical experience delivering intracranial B7-H3 #CARTcells to treat #DIPG in @CD_AACR, a journal of the @AACR. #1: on behalf of @seattlechildren & @SCTherapeutics, we are humbled by our patients' trust and bravery. (1/2) aacrjournals.org/cancerdiscover…

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ACIR@ACIR_org·29 Eyl

SPOTLIGHT: Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell #lymphoma @Mark_Leick @SatyenGohil @gaddyg @MarcelaMaus. Originally published in @NatureMedicine. To read our summary click ow.ly/zu6N50KVJTZ and scroll all the way down.

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Toby Eyre@tobyeyre82·22 Eyl

Large propensity score matched study #axicel vs #tisacel in @NatureMedicine by @BachyEmmanuel et al Closely matched large cohorts ⬆️ ORR, CR, PFS & OS advantage for #axicel pts 1 yr OS 63.5% vs 48.8% p=0.0072 ⬆️ G1-2 CRS, & all grade ICANS in #axicel pts #CART #lymsm #DLBCL

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Mark Leick@Mark_Leick·15 Eyl

Unbelievably exciting to see the benefits of CAR-T being extended safely for non malignant conditions with high morbidity statnews.com/2022/09/15/lup…

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Mark Leick@Mark_Leick·12 Eyl

Its finally out @NatureMedicine ! Excited to share our work identifying an association between CAR-Tregs and relapse/resistance after CAR-T cell treatment in DLBCL via scRNAseq and then modeling it in vivo (along with much more!)

Gad Getz Laboratory@getz_lab

[1/6 🧵] Today @NatureMedicine! Cellular dynamics monitored over time at the #SingleCell level reveals new insights into why some patients with large B cell lymphomas respond better than others to #CARTcell therapy rdcu.be/cVqVs Read the main takeaways below 👇!

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Mark Leick@Mark_Leick·29 Tem

@JohnRossMD I think our seasoned ICU nurse even panicked a bit when this popped up while titrating pressors...

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Mark Leick@Mark_Leick·28 Haz

Thrilled to kick off the 10th Annual Industrial Symposium in Montpellier with the keynote lecture this morning!

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Entdecken

@NEJM @MGHNeurosurg @Majzner_Lab @DanaFarber @DFBC_PedCare @MarcelaMaus @DrFredLocke @jaepark