Mark Leick

26 posts

Mark Leick banner
Mark Leick

Mark Leick

@Mark_Leick

MD | Assistant Professor at HMS | MGH Bone Marrow Transplantation and Cellular Therapy | Leick Lab | @OslerHousestaff 2014-2017

Boston, MA Katılım Aralık 2016
123 Takip Edilen256 Takipçiler
Mark Leick retweetledi
Eli Darnell, MD
Eli Darnell, MD@EliDarnellMD·
nejm.org/doi/full/10.10… Amazing findings coming out of the Maus lab! Great step forward to GBM treatment. Congrats to all the authors on their incredible work.
English
0
3
9
1K
Mark Leick retweetledi
Majzner_Lab
Majzner_Lab@Majzner_Lab·
Excited to share that @Majzner_Lab is moving to @DanaFarber @DFBC_PedCare as of Sept. Bittersweet to leave Stanford, but looking forward to growing our research program both in the lab and in the clinic. Hiring postdocs, scientists & lab manager- please reach out if interested!
English
38
24
283
56.4K
Mark Leick retweetledi
Klebanoff_Lab
Klebanoff_Lab@KlebanoffLab·
🚨Next-level T cell engineering enters the clinic! DNA base editor to simultaneously silence CD7 (minimize fratricide), TCRB (minimize GVHD), and CD52 (host pre-conditioning) in allo CD7 CAR-expressing T cells for T-ALL. No DNA cuts, no translocations. nejm.org/doi/full/10.10…
English
0
44
164
28.7K
Mark Leick retweetledi
Majzner_Lab
Majzner_Lab@Majzner_Lab·
Really happy to see the wonderful work from colleagues in Rome using 3rd gen GD2 CARs for neuroblastoma. This is the largest series of CAR T responses in a solid tumor to date & the fact that it’s in a pediatric cancer is awesome! Bravo! nejm.org/doi/full/10.10…
English
2
35
172
27.5K
Mark Leick retweetledi
Majzner_Lab
Majzner_Lab@Majzner_Lab·
Happy to share the newest paper from our lab. Led by technician extraordinaire Aidan Tousley (soon to be an MD/PHD student!), this manuscript details our attempts to reimagine the structure of CARs to improve their specificity and efficacy. rdcu.be/c7avS
English
24
78
318
68.3K
Mark Leick retweetledi
NatureRevClinOncol
NatureRevClinOncol@NatRevClinOncol·
'Multiomics STEP up in correlative analysis of response to CAR T cells'. In this article, Mark Leick & Marcela Maus discuss the potential of cfDNA-based analyses to inform on CAR T cell expansion kinetics & tumour-infiltration patterns in patients: nature.com/articles/s4157…
NatureRevClinOncol tweet mediaNatureRevClinOncol tweet media
English
0
28
63
9.8K
Mark Leick
Mark Leick@Mark_Leick·
Hope you picked up your badge at the airport… 😬#ASH22
English
1
1
12
0
Mark Leick retweetledi
Saheli Sadanand
Saheli Sadanand@SaheliSadanand·
Thoughtful piece in @NatureMedicine from @Eddie_Cliff, Reid Merryman, Philippe Armand and Caron Jacobson @harvardmed @DanaFarber on #CARTcells in #DLBCL. Thanks for writing this! #lymphoma #lymsm
Eddie Cliff@Eddie_Cliff

Our commentary in @NatureMedicine addresses 3 critical unanswered questions in the use of 2L CAR-T for DLBCL: 1) How to approach patients w chemo-sensitive disease? 2) Bridging therapy & 3) cost. Would love to hear your thoughts (no paywall): rdcu.be/cZfkl #lymsm

English
0
2
7
0
Mark Leick
Mark Leick@Mark_Leick·
Its finally out @NatureMedicine ! Excited to share our work identifying an association between CAR-Tregs and relapse/resistance after CAR-T cell treatment in DLBCL via scRNAseq and then modeling it in vivo (along with much more!)
Gad Getz Laboratory@getz_lab

[1/6 🧵] Today @NatureMedicine! Cellular dynamics monitored over time at the #SingleCell level reveals new insights into why some patients with large B cell lymphomas respond better than others to #CARTcell therapy rdcu.be/cVqVs Read the main takeaways below 👇!

English
2
10
51
0
Mark Leick
Mark Leick@Mark_Leick·
@JohnRossMD I think our seasoned ICU nurse even panicked a bit when this popped up while titrating pressors...
Mark Leick tweet media
English
1
0
3
0
Mark Leick
Mark Leick@Mark_Leick·
Thrilled to kick off the 10th Annual Industrial Symposium in Montpellier with the keynote lecture this morning!
Mark Leick tweet media
English
1
3
25
0

Keşfet

@NEJM @MGHNeurosurg @Majzner_Lab @DanaFarber @DFBC_PedCare @MarcelaMaus @DrFredLocke @jaepark