Matthew Certain
4.7K posts

Matthew Certain
@MatthewCertain
interventional cardiologist, cyclist, triathlete, marathoner, and father.






Cardiologists have set an LDL target the human body can’t reach on its own without a pill. So either nature got it wrong OR the guidelines did. I know where I’m putting my money.

















Left atrial appendage occlusion device embolization 😱. Remember your checkpoints 🛑: 🟦 WATCHMAN → PASS criteria P – Position: ≥50% of device within the LAA A – Anchor: Anchors engaged with stable fixation (tug test) S – Size: Appropriate compression target 8–20% S – Seal: Adequate closure with no peri-device leak >5 mm 🟩 AMULET → CLOSE criteria C – Circumflex: ~⅔ of the lobe distal to the LCx plane L – Lobe: Lobe appropriately compressed O – Orientation: Coaxial alignment with the LAA axis S – Separation: Clear separation between lobe and disc E – Ellipse: Disc assumes a concave/elliptical shape indicating good apposition #LAAO #EPeeps #iecho #Echofirst #Cardiotwitter #CardioX

Exactly. In cardiac surgery the type A dissection or emergent CABG tend to show up at the worst times


Peter Steinberger is joining OpenAI to drive the next generation of personal agents. He is a genius with a lot of amazing ideas about the future of very smart agents interacting with each other to do very useful things for people. We expect this will quickly become core to our product offerings. OpenClaw will live in a foundation as an open source project that OpenAI will continue to support. The future is going to be extremely multi-agent and it's important to us to support open source as part of that.




@drjohnm I agree rosuvastatin is a good drug, but here the baseline rate in control is 2.5% so mathematically ARR would max out at 2.5%. However very few therapies in medicine have been 70 or 80 or 100% effective even against placebo let alone active control like here-1/2












