Pinned • Free Peptide Tracker

pinned is a free peptide protocol tracker. safety engine. PK simulator. injection site mapper. bloodwork tracking. scheduling. 36+ compounds. 25 outcome modules. no paywall. no gatekeeping. heres what it looks like inside 👇

@TMTLongShort reta does that to people. next thing you know you need an app just to keep track of it all 👀

Two months into Reta. Already stocked up. Gateway drug fr fr

@vintweeta achieving BMI under 25. the obesity conversation just became a cure conversation.

What a time to be alive Comprehensive and broad-ranging ph3 data drop from LLY on #retatrutide at ADA yesterday, across obesity, obesity + osteoarthritis, obesity + sleep apnea, and diabetes A historic announcement in many ways, but the magnitude of the BMI category shifts (…aka cures) are particularly striking: >65% of patients with obesity achieved BMI < 30 (eg no longer obese!) and >33% of patients with obesity achieved BMI <25 (healthy weight!) investor.lilly.com/news-releases/…

@realpeptides 1 in 8 fully pain-free on the OA data is huge. its a primary endpoint for an entirely different patient population who haven't been in the peptide conversation at all yet.

Retatrutide additional phase 3 results are out, and the data keeps getting better: - 28.3% bodyweight lost on 12mg over 80 weeks (70.3 lbs) - 30.3% at 104 weeks in higher-BMI patients (85 lbs) - 65.3% dropped below the obesity BMI threshold - Knee osteoarthritis pain reduced by up to 75.8% (1 in 8 patients are fully pain-free) - Obstructive sleep apnea significantly improved - Major drops in triglycerides (41%), non-HDL cholesterol (24.2%), and blood pressure - A1C fell up to 2.0% and weight down 16.8% in diabetic patients, in just 40 weeks For those that are unfamiliar, retatrutide now has Phase 3 data showing it reaches well beyond weight loss. It directly treats the complications that have historically required entirely separate medications. This is becoming a new category of medicine, and the data is only getting stronger.

@operationdanish the A1C to 5.7% stat is the best stat. not treating obesity anymore its reversing prediabetes in people who were already diabetic. coverage argument writes itself!

🤯 JUST IN: INCREDIBLE PHASE 3 DATA ON RETATRUTIDE PRESENTED AT ADA At ADA this weekend, Eli Lilly ($LLY ) presented new Phase 3 data from TRIUMPH-1 and TRANSCEND-T2D-1. BLUF: 28% (70 pounds) weight loss. Unreal. In TRIUMPH-1, participants receiving 12 mg of retatrutide lost an average of 70.3 pounds (28.3%) over 80 weeks. Nearly half achieved at least 30% weight loss, and 65.3% were no longer classified as obese (BMI <30) by the end of the study. Among participants who started with BMI ≥35 and continued treatment to 104 weeks, average weight loss reached 85 pounds (30.3%), with no evidence that weight loss had fully plateaued. What stood out more was the breadth of effect across obesity-related conditions: Knee osteoarthritis pain improved by 73.1% Obstructive sleep apnea severity improved by 60.6% Triglycerides fell by as much as 41.0% Non-HDL cholesterol declined by 24.2% Systolic blood pressure dropped by 12.3 mmHg Waist circumference decreased by 9.5 inches Meanwhile, in TRANSCEND-T2D-1, retatrutide produced A1C reductions of up to 2.0% from a baseline of 7.9%. 90% of patients achieved A1C <7% 85% achieved A1C ≤6.5% 46% reached A1C <5.7%, which is below the threshold used to define prediabetes Patients lost 36.6 pounds (16.8%) at 40 weeks, and weight loss was still ongoing at study end. Obesity medicine is increasingly becoming outcomes medicine. Historically, we have evaluated obesity drugs primarily on percent weight loss... but payers ultimately care about sleep apnea, osteoarthritis, diabetes, cardiovascular risk, and healthcare costs. The significance of TRIUMPH-1 and TRANSCEND-T2D-1 is that Lilly is beginning to show a coherent story across those endpoints, not just body weight. I expect this to expand coverage dramatically. Eli Lilly is the Nvidia of healthcare.

@Polymarket the sleep apnea data is the one that moves insurance and prescribing. weight loss is lifestyle framing. apnea is a disease endpoint. its a different conversation with a different payer and a completely different patient population finding their way to peptides.

JUST IN: Eli Lilly says its experimental obesity drug cut sleep apnea severity by 60.6% in a Phase 3 trial.

@ToddESingleton SS-31 daily? most run 3-5x/week. Solid stack selection

I'd like opinion on the next stack: AM: Mots-C NAD+ SS-31 Semax/Selank - nasal PM: GHK-Cu BPC KPV Tesa/Ipa Reta - 1/6day

retatrutide just posted phase 3 obesity data and the numbers are not subtle glp-1 plus gip plus glucagon in one molecule. the glucagon arm is what pushes it past tirzepatide on fat loss the tradeoff is a small resting heart rate bump. not medical advice. who here is waiting on approval vs running grey market?

start date. dose changes. missed days. symptoms. sleep. mood. energy. appetite. all tracked. all correlated. not a checklist you forget about. a system that runs with you.

@pepfessions many such cases! but are they tracking them?!

I started with Reta and now I have 7 different peptides in my weekly stack as well as TRT

@CDM121179613131 ha love that! looking forward to it 🫡

@Pinned_Life I went through them the other day reading. I will have to look again to make a suggestion. I will put that on the todo list.

every peptide we cover has a companion guide. evidence-graded cofactors, timing phases, toxicity ceilings, drug interaction flags. we have also done the research on the debate to capture both sides of the story. just added kpv, cerebrolysin and dsip to the fold. which compound should we build next? not medical advice

@drmarlonperalta mistake 4 is the one that gets you. the cut is the easy bit, the dismount is where it comes undone and the regain data is brutal on that

The 4 mistakes retatrutide users make that trap them in low-calorie hell - and what to do instead. (for those who don't want to eat toddler-sized meals for the rest of their lives) 1. Using retatrutide to restrict harder

@WolverineDavis nobody preps for six markers moving at once off one injection the scale shows you bodyweight and nothing else, you are blind on the other five the real unlock is one compound one dashboard

🚨 Lilly just released additional Phase 3 retatrutide data, and I think the biggest story isn't the 70-pound average weight loss. Think of obesity like the cracked foundation of a house. Instead of fixing the roof, the walls, and the windows one at a time, what if you repaired the foundation itself? ✅ 70.3 lb average weight loss ✅ 65% no longer medically obese ✅ 73% improvement in knee osteoarthritis pain ✅ 60% improvement in sleep apnea ✅ Up to 2.0% A1C reduction ✅ Major improvements in blood pressure and triglycerides The most interesting question may not be "How much weight did people lose?" It may be, "What happens when you treat one of the root drivers of so many chronic diseases?"

the mouse data on reduced gh tone and lifespan is hard to argue with but it gets complicated because circulating igf-1 doesnt tell you receptor sensitivity or activation so two people at the same level are not running the same risk. thats why the number alone is a bad place to make the call

Any peptide that increases the GH/IGF-1 axis to supranormal levels is likely going to shorten lifespan. Make your own choices but be aware of the consequences.

@hubermanlab @AbudBakri sourcing and purity get all the airtime but the bigger variable for home users is everything after the vial. dosing drift, no rotation, stacking blind. experiments in your home, sure. an experiment you do not record is just a vibe. that gap is why we built pinned

Peptides sourcing and safety. @AbudBakri on the Huberman Lab podcast out now.

bpc was isolated from gastric juice and works on the gut locally before it degrades, so oral makes sense for the gut claims. the rest, tbi, hair, dopamine receptors, is mostly rat data, and standard oral is only around 3% bioavailable anyway, so those systemic effects assume blood levels oral mostly doesnt hit.

people always say "start from the inside out" and this is EXACTLY what oral BPC-157 does: - it reverses dopamine receptor desensitization from chronic stimulant use leading to actual receptor restoration - it counteracts alcohol damage to the liver, stomach, and brain at the same time - it modulates nitric oxide bidirectionally - raising blood pressure when too low, lowering it when too high. - it repairs peripheral nerve crush injuries through VEGF and growth factor upregulation. - it promotes organized collagen deposition instead of scar tissue; better function and appearance post-injury. - it restores gut barrier integrity, which cuts lps translocation into the bloodstream, indirectly resolving neuroinflammation-driven depression and anxiety - it accelerates closure of intestinal fistulas, which almost nothing else does clinically - it protects the gut lining while you're on NSAIDs instead of fighting them - it upregulates VEGF in hair follicles - improved blood supply, better density in diffuse thinning. - it repairs oral and periodontal tissue - documented in dental research almost nobody reads - it is one of the only compounds with legitimate TBI recovery data at the structural level most compounds treat symptoms, BPC-157 repairs the root issue. be smart. be based. fix your gut. not medical advice.

sure. bpc and tb500 as a blend is usually run daily, 4 to 8 weeks, then assess. bpc wants daily dosing and tb500 has a longer action so the daily blend covers it. 250 to 500mcg of each daily is the common range. we wrote both up properly on the blog with protocols, links in our bio. way easier to follow than a reply.

@Pinned_Life @JayCampbell333 Hello @Pinned_Life what’s dosage and how many times a week for BCP-157-TB500 how long to take it ? I bought from @JayCampbell333 site but need to pay monthly fee to ask questions

GLP peptides are either being massively overhyped… or massively misunderstood.  The mainstream narrative swings between two extremes: “Magic weight loss drug.” OR “Dangerous lifelong dependency.” Both miss the bigger picture. When used intelligently and strategically, GLP-1s are one of the most powerful metabolic optimization tools ever developed.  The problem is NOT the compounds. The problem is the protocols. Most people are: Overdosing Under-eating protein Losing muscle Ignoring resistance training Treating GLP-1s like a shortcut instead of a tool That’s why outcomes vary so dramatically. Used correctly, these peptides can help regulate appetite signaling, improve insulin sensitivity, reduce inflammation, quiet addictive food behaviors, and create the metabolic flexibility most people lost years ago. This is NOT about chasing skinny. It’s about restoring metabolic function in a world designed to destroy it.  The future of health optimization belongs to people who understand precision, personalization, and biology-driven protocols. Fear comes from ignorance. Mastery comes from education. Head to the link in my bio to grab my book, Metabolic Awakening, to learn everything MUST KNOW about GLPs.

@HunterEsoteric the coa is a synthesis snapshot. once its in bac water it degrades over weeks, so a heat excursion or a vial open a month leaves you underdosed with powder that passed every test. you cant see it. half the inconsistent results people blame on the compound are degraded vials.

@Pinned_Life This is the better argument. Clean powder is the floor not the ceiling. Purity is not the same as potency and most people never think to match the lot number on the COA to their actual vial. Matters way more than where it was made.

the regain worry is grounded, step 1 extension saw two thirds of the loss come back within a year of stopping. but the ones who held it built training and protein habits while actually on the drug, not afterwards the kids dropping 40lb fast is body comp get overlooked with roughly a quarter to forty percent of glp1 weight loss being lean mass. at 18 thats muscle and bone you really want to be adding, not shedding.

What we still don't know about GLP-1s: "The GLP-1 is a giant signal to the brain of don't eat." "What happens to all these young kids that are 18, 19 years old on 5 milligrams of retatrutide that have lost 30, 40 pounds? Are they going to have to be on that for life now to maintain that weight?" "We don't know what the long-term effects of those are on neuroplasticity." @AbudBakri on @hubermanlab