Ben Prosser

What a privilege to have the team and opportunity to try and help my daughter and those like her live healthier, fuller lives. We will be a relentless force for good against #RareDisease. @IngoHelbig @lab_davidson @ChildrensPhila @PennMedicine tinyurl.com/yf649bcc

Prof. Benjamin L. Prosser and his team at the @Prosser_Lab at @PennMedicine are researching the heart on a molecular level. Learn more about how his personal story motivated him to work on transformative cardiac and gene research. Visit zeiss.com/prosser #Health

@LucieCarrier84 lab provide evidence that targeting #tubulin #tyrosination could be a novel approach for improving heart function in patients with #HCM. Learn more at ahajrnls.org/3A2ZuMP @Prosser_Lab @mcaporizzo @CyxChristina @dirkwestermann @LucasBacmeister

This study, conducted in close collaboration with @curestxbp1, aimed to identify the rate & causes of early mortality in #STXBP1-related disorders. These results are important for family & prognostic counselling💜 @FrancescaFuria_ @Elegardella 👏 link.springer.com/article/10.100…

$$$ for #RareDisease research! RFAs for 35 different rare disorders through the @ODC_UPenn, including 2 x $70K grants available to @curestxbp1 courtesy of Lulu's Crew :) Info and app link here: bit.ly/MDBR2024RFA

Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab @Prosser scim.ag/7Nf

Want to know more about what ENDD is doing for rare 🧠disorders like @cureSYNGAP1 and @curestxbp1? Updated website here! endd.med.upenn.edu @ChildrensPhila @PennMedicine @lab_davidson @IngoHelbig @EAHellerPhD

@Chris_W_Ward @ScienceTM @MarguliesLab Cool! Is it out in press, or what’s our ETA? Please share when available!

@Prosser_Lab @ScienceTM @MarguliesLab Very exciting work! Our newly accepted paper in JMCC (yesterday) will add understanding to the trajectory of MT change and EC coupling gain in HFpEF.

Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab 1/5 tinyurl.com/ynn6r2mz

@HesselAnthony @tweetineaton @MCaporizzo Indeed - and now with a small molecule we can run the experiment! An additional interesting question with this approach is even if stiffness course corrects, might we still speed relaxation (and how much functional benefit will that confer)?

@Prosser_Lab @tweetineaton @MCaporizzo Really fascinating work! In the literature, changing any part of muscle stiffness has an effect elsewhere (often includes titin mods) that counteracts whatever other stiffness change occurs. I wonder what the long term effects will be with this treatment.

Next big step - determine chronic efficacy (and safety!) with sustained treatment to prevent progression of HFpEF (and other forms of HF). Awesome effort from @tweetineaton @MCaporizzo and Ben Lee.

In vivo, overnight VASHi was well tolerated, and improved ventricular relaxation and diastolic function in advanced HFpEF. (opinion - that's pretty cool for just targeting a microtubule PTM!) 4/5

@Prosser_Lab @Rongtian2 The traditional #GRC soccer game ⚽️ 🥅 #GRCcardiac2024 #CardiacRegMechanisms #ColbySawyerCollege

Check out our new paper @jclinicalinvest by the great @Ramihdd and @shkedio. We show that the protein RPSA is required for ribosome localization, localized translation, and the maintenance of the sarcomere. dlvr.it/T6vjhn

Happy birthday Lu! 6 years - and now standing by yourself! I have too many feelings to tweet, so I'll just say THANK YOU to everyone who has supported Lucy, or who is fighting to improve the lives of those with #raredisease. Keep going.

@bomba_ewa @UPennPhysiology @PennMedicine Yeah!! We’re so pumped for you to join us!

Thrilled to share that I will be starting as an Assistant Professor in the Department of Physiology at the University of Pennsylvania @UPennPhysiology @PennMedicine in January 2025!

Keep going Brett.

Don't miss the premier conference for fundamental and translational cardiac research! Program in link, still with open talk slots to be selected from abstracts. #CardioTwitter @Rongtian2 @KimHellgren @Heart4Carolina grc.org/cardiac-regula…

These are BEAUTIFUL 👏tissue mechanics in living myocardial slices by the Caporizzo Lab. They define (with precision) how targeting microtubules can improve cardiac function by facilitating relaxation and early diastolic filling.