Leo James' Lab

Postdoc position in dendritic cell and cross-presentation biology - four days left to apply: mrc.tal.net/vx/mobile-0/ap… Join our team to work on these coolest cells ever! 🥰

Join the RNA Virus Replication Lab @TheCrick, Europe's largest biomedical institute under 1 roof! 🔴 TWO postdocs (4-6yrs) 🔴 ONE PhD student (4yrs, fully funded, all🌍) We’re looking for bright, motivated people, with the chance to develop & shape projects independently... 1/n

Researchers at @UKDRI and @MRC_LMB have developed two novel therapies that target tau aggregates in the brain and have shown promise in treating dementia in mice @w_mcewan @JamesLab9 biotechniques.com/proteomics/nov…

Scientists have developed potential therapies that selectively remove aggregated tau proteins and improve symptoms of neurodegeneration in mice, showing a promising approach for Alzheimer’s disease. More: orlo.uk/N50dm @UKDRI @MRC_LMB

@KajasteLab @lara_manganaro @DiazGrifferoLab @LubanLab @MickMenager @donna_mallery is on her way and she will present this new study from our lab: x.com/JamesLab9/stat…

Thanks to all authors of that study: @AlexKleinpeter @donna_mallery Nadine Renner, @AnnaAlbecka and Ole Klarhof. Great collaboration between our lab @MRC_LMB and Eric Freed's lab @NIH

In forced evolution experiments we identified K25A compensating mutations that restore hexamer/pentamer ratio and rescue the shape of the capsid

New study from the lab! Charged rings in the mature HIV capsid protein are required for formation of conical capsids: nature.com/articles/s4146…

We are looking for a PhD student to continue our exciting work on antiviral immune receptor Trim21! Contact us for any questions and apply here:

The UK DRI's @w_mcewan & @JamesLab9 (@MRC_LMB) have developed new therapies that selectively remove aggregated tau proteins - harnessing the unique capabilities of a protein called TRIM21. The treatment improved symptoms of neurodegeneration in mice👉buff.ly/47ogpFG

@KajasteLab Thanks Anna!

Amazing new study from the lab on targeted tau degradation technology:

New research from @JamesLab9 & colleagues presents 'RING-Bait', which employs an aggregating protein sequence combined with an E3 ubiquitin ligase to specifically degrade tau aggregates while sparing soluble tau (in vitro & in vivo) - impressive new tech! cell.com/cell/fulltext/…

Our recent contribution to work from Gabriella Santoro's lab with @AnnaAlbecka SARS-CoV-2 experiments. Check it out! @SS_Silvia88 @guipap_ @MRC_LMB link.springer.com/article/10.100…

Great to be in Leeds for #BUNYA2024 conference! The lab is new to #bunyaviruses so we are sure to learn a lot!

Congratulations to @MatteoAll and @LabSchafer! And well done to us!

@LiWu_UIowa @UIowaMicrobio @IowaMed @NCICCR_HIVDRP @AlexKleinpeter Congratulations Alex!