Jeremy Luban 🧬🦠🔬🩺🎸🎻

@KevinWNg Saw one in the People’s Republic of China.

@SolidEvidence Great thread Mark. Regarding timing, see our preprint on epistasis which we hope to publish someday: pubmed.ncbi.nlm.nih.gov/37034621/

Others said that N501Y gave a general growth advantage because it enhanced receptor binding. If true, why did it take so long to be select for it? 18/

We are now officially into year 5 of the SARS-CoV-2 pandemic/endemic. I gave a lecture to my virology class this Fall about the history of the pandemic through the lens of viral genotypes. I thought I would share that lecture as a thread. This is a long one. 1/

@PeaseRoland has this addiction: bbc.co.uk/programmes/w3c…

LINE-1 is associated with disease and aging. The @RoutLab_RU has uncloaked the core of its key protein, pointing the way towards therapeutic targets. #RockefellerScience rockefeller.edu/news/35133-rev…

@HarmitMalik Yup! Been cleaning up such a mess all week. Hopefully it won’t drag on for ever and ever and…

TFW someone asks you for advice, you give it- under no circumstances should one do this thing, the person asking does that thing anyways, shit show ensues, they then blame you for not giving them good advice, & you just nod your head apologetically. Because its almost Christmas.

No fruit bats are not magic animals that do not suffer disease consequences of bacterial and viral infections (pathology studies like these are very painstaking to perform) sciencedirect.com/science/articl…

I couldn't have ended the year with a better gift than to be able to broadly share the main story of my PhD work, recently published in @PNASNews. We found that #PCF11 associates with #WDR82 to silence HIV-1 in latently infected cells. Full article ➡️ doi.org/10.1073/pnas.2…

The HUSH complex guards vertebrate genomes from retroelements. Our new structural/biochemical study on MPP8 reveals the interaction interface with TASOR required for HUSH assembly & suggests links between HUSH & SUMO doi.org/10.1101/2023.1… @daniilprigozhin @MedCambridge @MRC_LMB

Looking for a motivated postdoctoral research scientist with cryo-EM and biochemistry experience to join our group to study virus-host interactions and coevolution. We benefit from a great environment @MRC_LMB @MedCambridge @Cambridge_Uni jobs.cam.ac.uk/job/43440/

Cornell Molecular Biology and Genetics department @CornellMBG has an open call for faculty applicants. Interested candidates please apply. All others please RT. Without a shadow of doubt I have loved it here. academicjobsonline.org/ajo/jobs/26845

How big is Africa, in reality.

“Transposable elements contribute to nearly 80% of human-specific candidate cis-regulatory elements in cortical cells” 🧠 …🤯 literally! Amazing dataset 🔥 Congrats to all involved! nature.com/articles/s4158…

🔔'Tis the season...to apply for a new job?! My group @MedCambridge is recruiting for 2 posts: Postdoc: jobs.cam.ac.uk/job/44181/ Research assistant: jobs.cam.ac.uk/job/44250/ Both roles will seek to improve our understanding of coronavirus cross-species transmission. #preparedness

🔥🔥How does the LINE-1 retrotransposon jump around in the human genome? Super excited to present my postdoctoral work answering this published today @Nature together with twitterless Kathy Collins's lab and @NogalesLab @UCBerkeley nature.com/articles/s4158… A 🧵

Mucosal antibodies in people with infection, not in vaccinated-only individuals. This is a correlate of protection from infection, although not fully validated thelancet.com/journals/ebiom… Great work, based on paired nasal and blood sampling

Very excited by our results @Nature showing that IL4R signaling is strongly enriched in myeloid cells that infiltrate mice and lung cancer lesions nature.com/articles/s4158…

YES! 💯Thanks Massimo and all who helped organize #RetroPath. What a blast it was! A few intense days of amazing 🦠 science in a stunning spot. I’ve learned a ton and made a bunch of new friends! 🥰

A big thanks to our fabulous host Massimo Pizzato of @UniTrento for hosting this year's #RetroPath meeting, it was fabulous!

New day, new sessions @Retro_Path @MUSE_Trento

Great talk by Hanna-Mari @Baldauf_Lab comparing antiviral activity of Guanyl-binding proteins of 🧒🐭 🐰! GBP2 & GBP5 are some of my fave restriction factors bc both are activated by retroviral LTRs as @SmithaBadarina2 showed nicely before #RetroPath academic.oup.com/nar/article/48…