BranThrough

Ever bought peptides and wondered if your vial actually matches the lab report the vendor showed you? Yeah, me too. That's why I built BatchGuild. A marketplace for VERIFIED lab test results, scraped directly from testing labs. No photoshop, no fake PDFs. 🧵

There are no clinical trials for MOTS-C. Absolutely none. They injected a mouse with it and asked it to run on a treadmill. It was some PhDs research project

Every time I tell someone in peptides they’d rather just stick to GLP1 + Diet + Exercise + Sleep, they begin to start seizures, butttt BPC cured my rotator cuffs

@rorynotsorry Selling peptides is always going to be a risky venture given the amount of money involved

This is not a good sign for the market when people are trying to dump their Peptide businesses. Add in the logistics issues from overseas, the FDA changes… the golden age of research may be over.

After multiple months of running Peloton and a weight training program my HRV is the highest it’s ever been. No peptides outside a GLP1 have contributed

@China__Captain @drmikehart @AbudBakri I don’t need Chinese peptide suppliers. I’d much prefer it compounded in the US

Peptides shouldn't be expensive. BPC-157 costs pennies to make. A 10 mg vial costs under $15 to produce. But companies charge $100–300. People are getting ripped off.

@hamandcheese Reta and increased energy is a common theme. I find it’s almost as if your body’s metabolism is back to its 18 year old self

I'm on week 4 of retatrutide and already down 12.4 lbs. More interestingly: - I seem to have much more energy and focus - I find myself spontaneously preferring standing desks, walking rather than ubering, opting into exercise etc. - My blood sugar no longer crashes after eating - I don't drink nearly as much but when I do my hangovers seem a lot weaker - My food preferences spontaneously shifted in favor of fish, salads and fresh fruit - My GI health improved a lot, I think mostly thanks to it being easier to resist trigger foods I've had no negative symptoms or downsides, and am still on a low starter dose (~2.5mg)

@Jonestovvn @bryan_johnson Good point.

@LateToLongevity @bryan_johnson It means stop acting like a millennial-coded homosexual

Just spent over an hour with my clinical team debating which growth hormone peptide protocol to run. Still torn. Wanted to share the thinking and get your take. The goal: Increase GH and IGF-1 to support anabolism, recovery, and sleep, but also test a specific stacking hypothesis. Tirzepatide (GLP-1/GIP agonist) can elevate resting heart rate, disrupt sleep, and suppress appetite aggressively. CJC-1295 (GHRH analog) can worsen insulin resistance. The bet is that combining them cancels each other's downsides: CJC-1295's slow-wave sleep enhancement offsets tirzepatide's sleep disruption, while tirzepatide's insulin-sensitizing effects counteract CJC-1295's insulin resistance. Best of both worlds — or at least, that's the hypothesis we're testing. The two candidates: CJC-1295 with DAC: the long acting version. One injection per week, stays active for 6–8 days. This is what was used in the actual clinical trials. Raises GH 2–10x and IGF-1 1.5–3x from a single dose. Preserves GH pulsatility even under continuous stimulation. The tradeoff: if you get side effects, you're committed for a week. Harder to titrate. CJC-1295 without DAC + ipamorelin: the short-acting version paired with a selective ghrelin receptor agonist. Daily injections, pre-bed, clears in 30 minutes. Ipamorelin adds a second axis of GH release, pulse frequency via the ghrelin pathway, on top of the amplitude boost from CJC. No cortisol or prolactin elevation. This is what most clinicians prescribe and most of the peptide community uses. The tradeoff: less clinical trial data, daily injections, more anecdotal evidence base. What we're considering: Start with DAC at half dose 2.4 mg, then if well tolerated escalate 4.8 mg, weekly injection. If side effects aren't tolerable, switch to no-DAC + ipamorelin (100 mcg then 200-300 mcg daily, before bedtime). Or, Run both head to head. 2 weeks DAC, 2 weeks no-DAC + ipamorelin and compare. Tracking: GH, IGF-1, Cortisol, CGM, real time core body temperature, RHR, overnight HRV (rMSSD), IGF-1, HOMA-IR, sleep architecture, subjective recovery. The purist in us says stick with DAC; that's where the published data lives. Yet the pragmatist says no-DAC + ipamorelin is what thousands of people actually use, and testing it generates more socially relevant data.

@Jonestovvn @bryan_johnson What the fuck is a TS?

@LateToLongevity @bryan_johnson Can you please adopt a less faggy online persona please, TS is pathetic even for a millennial bro

@rorynotsorry I hope it decreases it. GLP1 to Tren pipeline remains undefeated

My take on what the FDA decision will do to the illicit gray market... neutral or grow it.

@rorynotsorry Best put GHK-Cu in everything

Later this year, I hope to be launching a topical peptide skincare / cosmetics line, that I am extremely excited about.

@HunterEsoteric This is from March 15 sir. What are you talking about

@AbudBakri Atleast you won’t inject lead during self experimentation

Now here’s the problem Although I am a BPC-157 maxi, I don’t think the data will be sufficient to move its status Hope I’m wrong

@SecKennedy @DrCamRx Link so the algo does not deboost batchguild.com/pharmacies/

@SecKennedy @DrCamRx What an awesome job! Find a list of all FDA approved compounded pharmacies selling compounded peptides @ BatchGuild

Today, we took long-overdue action to restore science, accountability, and the rule of law. In September 2023, the Biden FDA pushed a number of peptides into Category 2 — “Bulk Drug Substances that Raise Significant Safety Risks” — driving a dangerous black market that puts Americans at risk. Now, after nominators withdrew 12 peptides, the FDA will remove them from Category 2 and will bring them to PCAC at its next two meetings, beginning in July—where independent experts will rigorously evaluate each substance on its scientific merits using full clinical, pharmacological, and safety evidence. • BPC-157 • Thymosin beta-4 fragment (LKKTETQ) • Epitalon • GHK-Cu (injectable) • MOTS-c • DSIP (Emideltide) • Dihexa Acetate • Ibutamoren Mesylate • Melanotan II • KPV • Semax (heptapeptide) • Cathelicidin LL-37 This action begins to restore regulated access and will immediately begin shifting demand away from the black market. We will follow the science, enforce the law, and deliver the clarity patients, providers, and pharmacies deserve.

Just in time for the directory of compounded pharmacies that have peptides which I launched yesterday. Great move secretary!

Just did a big list of compounding pharmacies doing Peptides on the website, let's take the market back.

Is training on a GLP1 still being natty?

@Lynchy_LFC @rorynotsorry I would definitely advise the 20lbs overweight to get a Dexa scan first to compare their body fat % instead of relying on BMI which is for population levels. a skinny fat frame can be obese too

@rorynotsorry whats your view on people say 20lbs overweight? would you encourage them to take the skinny jab?

Anti-GLP1 Karens would rather you were 100lbs overweight instead of using GLP1s because there is a 4% chance of you having osteoporosis. Seems like it would be easier to just encourage people to get more calcium and Vitamin D. But what do I know...