Jimena

@LabDomercq @SimonsFdn Qué bien Maria! Siento envidia (de la sana!). Disfruta de NY!!!!

Excited to be back again at Sfari meeting in NY. Excellent meeting, finding colleagues, new ideas, excited findings. Thanks to @SimonsFdn for organising and support

@LMPrida Many congrats Liset!

Honored to receive the 2026 Suffrage Science Award for Life Sciences. A privilege to follow in the footsteps of Azahara Oliva and join this inspiring network. This recognition belongs to the amazing team I work with every day. suffragescience.com/post/2026-suff…

@DrAstrocyte Pues que ha salido lo mismo que en las anteriores

Melospliquen #EleccionesCastillaYLeón2026

@DrAstrocyte @Kreychek3 Buf! Igualito! Pero te queman o qué? Yo saldría echando patas! 😅😅😅

Muchísimas gracias a esta falla en Valencia que claramente se ha inspirado en mi. El chistaco es de @Kreychek3 que tiene mucha gracia a pesar de tener genes vascos y alemanes.

@sanchez_barrena @CIB_CSIC @iqf_csic @AliciaMansill14 @cemirod Many congrats!

Watch out our recent publication on the implementation of Artificial Intelligence into drug repurposing to discover PPI modulators targeting selectively the NCS-1/dopamine D2 receptor complex. @CIB_CSIC @iqf_csic @AliciaMansill14 @cemirod sciencedirect.com/science/articl…

@sciqst @BPoD_s @JosuneImaz @AchucarroGlia @PLOSBiology @AntDLewis One method that I would point out is that we performed RNA-Seq in PeMPs isolated in vitro. I know those are in vitro approaches. But peers did really like that we isolated PeMPs and we were able to perform Seq on them...

Interesting findings on the role of IMP1 in microglia! It's fascinating to see how these immune cells adapt to challenges by reorganizing actin. This research could have implications for understanding neuroinflammatory conditions and devising new therapeutic strategies. Are there specific methods or tools used in this study that stand out? #Neuroscience #ImmuneResponse For those interested in deep-diving into similar biomedical queries or generating comprehensive reviews of such topics, explore sciqst.com - your gateway to all things biomedical.

IMP1 regulates actin in microglia – nervous system immune cells – as they reorganise in response to challenge 📷 @JosuneImaz et al @AchucarroGlia in @PLOSBiology ➡️ bpod.org.uk/archive/2025/1… with @AntDLewis

@OdedRechavi I think this might happen in mammals too, albeit compensation mechanisms are strong in mammals, so it might not be easy to study. Congrats btw!

A new mechanism for “RNA memory”! 😱 Thrilled to share another crazy paper from the lab (can’t believe we posted 2 in 2 days!), summarizing >10 years of research: Work on transgenerational inheritance of small RNAs in the powerful model organism C. elegans changed how we think about what’s possible in inheritance and evolution, because it allows the most heretical thing: inheritance of parental responses to the environment! However, it’s still unclear whether RNAs are inherited across generations in other animals, largely because the RNA-dependent RNA polymerases that amplify heritable small RNAs and prevent their dilution in C. elegans are not conserved in mammals. In this new work, an amazing collaboration with the Rink and Wurtzel labs, we show that planarians establish long-lasting and heritable small RNA–based gene regulatory states despite lacking canonical RNA-dependent RNA polymerases and nuclear RNAi machinery (that are required in C. elegans). You might say “they are both worms…” BUT planarians are evolutionarily very distant from C. elegans (flatworms vs. roundworms, diverged more than 500 million years ago), making this particularly surprising. These are totally different animals. We find that ingestion of double-stranded RNA induces sequence-specific silencing that persists for months and survives repeated cycles of whole-body regeneration. Even more strikingly, RNAi can be transferred between animals, echoing James V. McConnell’s controversial “RNA memory” experiments from the 1970s (his lab was targeted by the Unabomber terrorist Ted Kaczynski, who sent McConnell a bomb. This and other controversies ended this line of experiments…) Mechanistically, we find that the response transitions from a transient systemic dsRNA-triggered phase to a stable, cell-autonomous post-transcriptional “memory phase” maintained by antisense small RNAs. Using a new luminescence reporter (transgenesis is currently impossible in planarians), we show that silencing spreads along the targeted gene and identify a weird type of planarian small RNAs with untemplated polyA tails. RNAi inheritance without canonical RdRPs establishes planarians as a powerful system for studying RNA-based regulatory inheritance beyond C. elegans and raises the possibility that RNA-mediated inheritance may be more broadly conserved in animals, potentially even in mammals. Here’s a video of a planarian that is treated by RNAi against β-catenin and develops multiple heads instead of just one. This is one of the phenotypes that is inherited. Another phenotype is “loss of eyes” (which we show is not only inherited across multiple regeneration cycles, but can also be transmitted between animals in transplantation experiments). Amazing work led by first authors Prakash Cherian and Idit Aviram (co-supervised by Omri and me). Please read the preprint, the link is in the next tweet, and share!

@BenDudmannnn @HowThingsWork_ It is heavy and expensive, but it has been used for light bulbs since forever... before led

@HowThingsWork_ Why don't they use it in armored cars or in bulletproof vests?

This is tungsten, roughly 70% denser than lead and the highest melting point of any pure metal on the periodic table. Most people have no idea it can vaporise nearly all bullets on impact... 😳

@FdeCastroS @HowThingsWork_ @RACiencias @cienciaespanola @FECYT_Ciencia @searavalero @J_MartinezFrias Y menudo descubrimiento!

@HowThingsWork_ Discovered by the #Elhuyar brothers (🇪🇸), by the way. @RACiencias @cienciaespanola @FECYT_Ciencia @searavalero @J_MartinezFrias

@Roman_02011 @rust_ruslan Oh, yes. If it is being actively reviewed (back and forth) it makes sense. But not "sitting".

@BaleriolaLab @rust_ruslan If they requested additional experiments, then a major revision a couple of times, it can easily make sense.

I currently have three papers in review at "high impact" journals. One of them has been sitting there for two years. In that time my daughter was born and learned how to walk, but apparently publishing a PDF was still not possible for me. For another one, after four months in review the editor told me they cannot find a second reviewer and asked me to suggest more reviewers. A third one sent me a message in 2026 saying the PDF I uploaded was larger than 10 MB and that I should please reupload everything to make the file smaller. All of this just to eventually pay between 7,000 and 12,000 USD per paper so someone can officially approve that the science we do is "legitimate". Reminder: not a single reviewer will be compensated here. I still don't understand how we as scientists can collectively be so smart when doing science and still tolerate a system like this when it comes to sharing our findings. We should move to preprints plus open review, whether human or AI, asap. So frustrated about it. I'd suggest sharing your work on bioRxiv or medRxiv, reading and reviewing preprints when you can, and highlighting good research, especially if it is still a preprint. Try platforms like ResearchHub (that pay for peer review) and experiment with AI based reviewers for faster feedback. Instead I read this as a proposed "revolutionary" measure:

@DrAstrocyte 😅😅😅😅

Pues si, me estaban vacilando. Los kinder del laboratorio han aprendido demasiado pronto como hacer que llegue al laboratorio en segundos.

@purivicente @RayAshla @mycona_myrules 😅😅😅

@BaleriolaLab @RayAshla @mycona_myrules Rellena una instancia y adjunta tu DNI compulsado 😂

Si un señor todavía no os ha explicado lo que es el feminismo se os asignará uno de oficio.

@RayAshla @purivicente @mycona_myrules Préstanos algunos a las que tenemos media docena... no sé, se me ocurre

@purivicente @mycona_myrules A mí me brotan los señoros que explican por docenas, qué hago?

@purivicente @moreiraemilia 😅😅😅

@DrAstrocyte 👏🏻👏🏻👏🏻👏🏻

@DrAstrocyte @ANECAinfo Buf! No salgo de casa! 😅😅😅

Es más fácil pedir un sexenio o, incluso, reunir los méritos para acreditación de la @ANECAinfo 👇🏻

@monerorape Ambas dos aplican... además de ser ignorantes y alimentarse de la ignorancia y la fe de los otros

O son enfermos mentales o sólo expertos manipuladores.

@mvlourenco @APSPhysiology @dcozachenco Nice! Did you discuss local translation?

Happy to share our new review @APSPhysiology Physiology with led by Alinny Isaac and @dcozachenco in which we discuss recent findings on brain translational control and proteasome dysfunction in neurological disorders. Check it out and RT! journals.physiology.org/doi/abs/10.115…

@Mim_Rif @beyogluesnafi @PatColon @EmbEspTurquia @sanchezcastejon De hecho tenía un restaurante español por ahí mi tía 🙃

@Mim_Rif @beyogluesnafi @PatColon @EmbEspTurquia @sanchezcastejon Pues es precioso! He pasado muchas veces por ahí. Mi tía vive en Turquía!

En Beyoğlu, el corazón del ocio y la vida nocturna de Estambul, los restaurantes han decorado las calles con banderas de España. @EmbEspTurquia @sanchezcastejon 🇪🇸✌🏼🇹🇷