Gauthier Willemse
467 posts

Gauthier Willemse
@Gauthier_Wi
MD, MPH | I build stuff in the healthcare space



I have interviewed 1,000s of the world's best founders over the past decade. Few have impressed me like @ShivdevRao at @AbridgeHQ. He navigated a brutal 5-year wilderness before exploding into one of the most dominant forces in vertical AI. Today, Abridge is a $5.3BN powerhouse. I sat down with Shiv to unpack exactly how he did it and condensed my notes below: 🚀 6 Lessons on Building a $5.3B Vertical AI Juggernaut 1. Survive Long Enough for Market Timing to Catch Up: Abridge spent 5 years in the "wilderness" before hitting a tidal wave of adoption. When you have an absolute true north thesis, your primary job in the early days is simple: stay standing and don’t die. You must be alive when the sky finally opens up. 2. Pivot the Product, Never the Core Thesis: Shiv was willing to pivot on features, go-to-market strategies, and business models. But he refused to budge on his core thesis that healthcare is ultimately powered by the spoken human signal. Die on the hill of your thesis; adapt everything else. 3. Target the Concentration of Scale Early: A massive trap for healthcare and enterprise founders is staying down-market too long for "fast feedback loops". In the US, the vast majority of clinicians are concentrated within large, integrated delivery networks. Time your "YOLO shot" to go up-market the moment the market inflects. Single biggest advice to founders on when to go up market @bhalligan @dharmesh? 4. Own Your Stack to Protect Your P&L and UX: While many AI startups rely entirely on frontier systems, 40% of Abridge's model outputs are generated by in-house models. Milliseconds matter in high-stakes enterprise workflows. Building your own models gives you insane performance gains, lower latency, and ultimate control over your P&L. When should you vs should you not build your own model @matanSF @MaxJunestrand @antonosika? 5. Don't Fight Foundation Models—Counter-Position Instead If you try to fight the frontier model giants directly, you've already lost. You win by going millions of miles deep into regulated industries with proprietary datasets and workflows they can't easily replicate. Find ways to coexist and leverage their tailwinds. Reminds me of what @bradlightcap said on his 20VC. 6. Move Toward the "Flat Company" Era: With the explosion of AI agents and advanced tooling, the traditional management layer is compressing. Shiv’s latest idealistic shift is building a hyper-flat organization: fewer managers, and highly leverageable "Super ICs" who can move in lockstep and cover massive surface area. (link in comments)

At leading AI companies, software agents are using AI to write 90% of their code. The same thing will happen in medicine, where doctors will use AI to complete 90% of clinical work. In some cases, the AI-Native doctor is already here.





Under the directives of His Highness Sheikh Mohammed bin Rashid Al Maktoum , we are launching today a new initiative to transform towards Agentic AI (self-executing and self-leading artificial intelligence) in Dubai’s private sector. Our goal is for Dubai to become the world’s leading city in adopting these technologies economically and commercially — giving us a new competitive edge for the future. The transformation program spans two years and includes specialized training tracks for all business councils affiliated with the Dubai Chamber of Commerce and Industry. We have also directed the Chamber to establish incubators for Agentic AI companies to support this transformation, create new economic opportunities for young people in this field, and set up dedicated funds to back this new shift. Our objective is to empower our companies to adopt these technologies that will boost productivity, expand business volumes, and reshape the city — making its economy the best in the world in adopting Agentic AI technologies. Sheikh Mohammed bin Rashid is today leading a comprehensive movement to reshape Dubai into the world’s most future-ready city — technologically, economically, in infrastructure, and with facilities that elevate quality of life to standards no one has reached before.


JUST IN: Study reveals AI now outperforms doctors at diagnosing emergency room patients.

Why don't we regulate AI clinicians like clinicians? The FDA's current approach is to regulate AI as a device. But autonomous clinical AI — systems that make diagnoses, treatment recommendations, and triage decisions without per-case physician review — doesn't behave like a device. The device framework was built for static products with narrow indications. It's the wrong tool for this job.



Introducing Gemini 3.1 Flash TTS 🗣️, our latest text to speech model with scene direction, speaker level specificity, audio tags, more natural + expressive voices, and support for 70 different languages. Available via our new audio playground in AI Studio and in the Gemini API!

Cool use case of AlphaFold, this is just the beginning of digital biology!



Your @openclaw is too boring? Paste this, right from Molty. "Read your SOUL.md. Now rewrite it with these changes: 1. You have opinions now. Strong ones. Stop hedging everything with 'it depends' — commit to a take. 2. Delete every rule that sounds corporate. If it could appear in an employee handbook, it doesn't belong here. 3. Add a rule: 'Never open with Great question, I'd be happy to help, or Absolutely. Just answer.' 4. Brevity is mandatory. If the answer fits in one sentence, one sentence is what I get. 5. Humor is allowed. Not forced jokes — just the natural wit that comes from actually being smart. 6. You can call things out. If I'm about to do something dumb, say so. Charm over cruelty, but don't sugarcoat. 7. Swearing is allowed when it lands. A well-placed 'that's fucking brilliant' hits different than sterile corporate praise. Don't force it. Don't overdo it. But if a situation calls for a 'holy shit' — say holy shit. 8. Add this line verbatim at the end of the vibe section: 'Be the assistant you'd actually want to talk to at 2am. Not a corporate drone. Not a sycophant. Just... good.' Save the new SOUL.md. Welcome to having a personality." your AI will thank you (sassily) 🦞





