Yuri Ivanov

@mkaeberlein Sad to read than. Hopefully the podcast continues.

Dear Friends, I want to share that I am no longer at Optispan, the company I co-founded in 2023 and have led since. I’m proud of what we built together and grateful to the team for their work and commitment. I wish them continued success. While I’m still considering what comes next, I remain 100% committed to the vision of helping as many people (and companion animals!) as possible achieve longer, healthier lives.

@KarlPfleger Do you consider the "replacement" approach (lab-grown organs, plasmapheresis, hair cloning, etc.) a part of one of these two fields, or something separate from (and presumably complementary to) both?

The 2 Longevity Fields... New post on a topic of great importance. Long, but something I feel strongly about. Broadly Slowing Aging vs. Divide-and-Conquer Rejuvenation: How to tell the difference and why acknowledging both matters (link in next post)

@siimland The problem with these estimates is that they come from cause-delete life table calculations. Real-life impact could (and possibly will) be much higher than the 5-10 years that those imply.

In the future, very few will die from cancer and heart disease. But it's estimated that eliminating both completely only increases life expectancy by ~5–10 years. The real dramatic gains in life expectancy will be achieved by figuring out how to slow down or reverse biological aging. Slide from @mkaeberlein

@terziev Много добре е станало като цяло, единствено нямаше да е лошо и подовата настилка да почисти.

Завършихме подлеза при ул. „Александър Жендов“. Преди няколко месеца там беше тъмно, таваните падаха, стените бяха надраскани, а кабелите висяха като лиани в джунгла. Днес е различно. Почистихме го, изградихме ново LED осветление, ремонтирахме тавана и прибрахме кабелите, а след нас влязоха 25 артисти, които вложиха труда си, за да превърнат бетона в галерия. Пиша отново за този подлез, защото той е пример за избора ни как да управляваме София. Всички знаете, че ние работим по визионерските проекти – училища, детски градини, нови паркове и инфраструктурни обекти, които ще променят града. Но няма как фокусът ни да бъде само върху големите и „лъскави“ неща, когато десетилетия наред основите са оставяни да гният. Не можем да чертаем планове за бъдещето, докато се спъваме в счупени плочки, пукаме гуми в дупките, а подлезите ни се разпадат буквално над главите. Налага ни се подлез по подлез, плочка по плочка, лампа по лампа и проект по проект да разплитаме десетилетното наследство от занемареност на ГЕРБ. И докато те все още се гордеят с „великото“ си управление, на нас се пада задачата да внасяме ред в хаоса, оставен в детайлите на града ни. Защото години наред на хората им е показвано, че занемареността е „нормалното“. А то не е. Но точно заради това отношение на бившите управляващи, сме свикнали сме да подминаваме занемарените места, сякаш не са наши. И когато някой ги оправи, често се намира друг, който да ги съсипе за една нощ, както се случи наскоро с обновения пешеходен подлез при алея „Яворов“ и както се случва истемно на стотици други места в града. Това е тревожен и много ясен знак, че все още има хора, които не усещат града като наш общ дом. “Те няма да спрат да драскат”, казват някои. И ние няма да спрем да ги хващаме. Няма да спрем да оправяме, това, което развалят. Вече имаме специализиран екип, който описва щетите във всеки подлез, засилен е контролът, предвидени са и по-високи санкции за нарушителите. Но истината е, че не можем да сложим камера на всеки сантиметър, нито да осигурим денонощен патрул за всеки подлез. Тези пространства ни свързват. Те са част от пътя ни към работа, към вкъщи, към приятелите. И ако искаме те да са чисти и светли, трябва да спрем да мислим, че „това е на общината“. Не, това е вашето пространство. Нека го пазим не защото някой ни гледа, а защото заслужаваме да живеем в нормален град, не в гето.

@statto I recently started wondering though, how accurate is the 90 percent really? For example, if a person dies at 20 from a brain tumor, we still count them towards it because cancer risk is clearly age-influenced, but their particular death is not 'caused by aging' per se.

90% of deaths in most rich countries are caused by aging. We have dozens of ways to slow aging in the lab. But the US invests $1 per person per year in aging research, 20× less than it spends on cancer research. Other countries are even lower.

@rand_longevity Given the fact that there are only 5 individuals older than 115 now, it's safe to say that not a single person would have gotten to 130 in 15 years. This will not turn into something we routinely do for at least 50 more years even if solve ageing tommorow.

if you can survive the next 5 years, you are gonna some wild stuff

@Dr_Singularity That's cool, but this therapy usually decimates your B-cell population for good, making you immunocompromised, so it's not free. We are still far from curing such diseases with no consequences at all.

Insane breakthrough in medicine Scientists used CAR-T cell therapy (normally used for cancer) to treat a woman with three severe autoimmune diseases at once… and it basically reset her immune system. Result: No symptoms No medication needed Stable for over a year What makes this amazing: She had already failed 9 different treatments. This was a last ditch attempt, and it worked. Advanced science will solve all diseases.

@ydeigin I don't see a lot of reason for 4 and 5, the rest are fine.

The idea of generating “brainless clones” for use as organ donors is getting a lot of flak recently but it made me wonder — we already accept organ donation from brain-dead individuals. So where exactly does the ethical red line fall when it comes to growing organs? Genuinely curious — where do people draw that line, ie which of these organ sources would you NOT be ok with? 1️⃣ 3D-printing organs from your own cells (iPSCs) 2️⃣ Growing your organs inside a xeno pig 3️⃣ A headless clone of you (never develops a head) 4️⃣ A clone body with a skull but no face or brain 5️⃣ A clone body with a head and face but no brain 6️⃣ I am ok with all of the above

@DrSamuelBHume If seemingly over 90 percent of the people treated with Teclistamab-Daratumumab go over four year progression free, what is the rationale behind subjecting them to any other lines of treatment?

I added some of the therapies from previous generations, to illustrate the progress that's been made here (in relapsed or refractory multiple myeloma after 1-3 lines of previous therapy) Pretty amazing!

@DrSamuelBHume The long tail improves, but what is the explanation for the steep drop that still happens in the first 24 months?

How immunotherapy transformed survival in advanced melanoma

@DrSamuelBHume What do you think about the TRIIM and TRIIM-X trials?

The big question is: how do we rejuvenate the aging thymus?

The thymus shrinks as we get older, so is it actually doing anything useful? This study (nature.com/articles/s4158…) measured thymic health based on CT scans, and found: 1. Better thymic health is associated with longer survival

@stats_feed Cuba lost between 15 and 25 percent of its population depending on the source just between 2020 and 2025. Given this list, one would assume you are expecting it to gain more people forward, which is ridiculous.

Largest expected population decline (2020-2050): 🇧🇬Bulgaria → 22.5% 🇱🇹Lithuania → 22.1% 🇱🇻Latvia → 21.6% 🇺🇦Ukraine → 19.5% 🇷🇸Serbia → 18.9% 🇧🇦Bosnia & Herzegovina → 18.2% 🇭🇷Croatia → 18.0% 🇲🇩Moldova → 16.7% 🇯🇵Japan → 16.3% 🇦🇱Albania → 15.8% 🇷🇴Romania → 15.5% 🇬🇷Greece → 13.4% 🇪🇪Estonia → 12.7% 🇭🇺Hungary → 12.3% 🇵🇱Poland → 12.0% 🇬🇪Georgia → 11.8% 🇵🇹Portugal → 10.9% 🇲🇰North Macedonia → 10.9% 🇨🇺Cuba → 10.3% 🇮🇹Italy → 10.1% Source: World Population Review

@idobadtakes @DrSamuelBHume Colon cancer is not rare at all - it is the third most common cancer in the world and the second leading cause of cancer death. I'd speculate there is rather a problem with this study.

@Itilon @DrSamuelBHume There is a small but real chance that the colonoscopy itself kills you. It’s something like one in a million, but if colon cancer is rare enough that can be enough to counteract the benefits

Does cancer screening increase lifespan? Read my article here! breakingground.substack.com/p/does-cancer-…

@DrNeilStone Nonsense! We all died in or before December 2025, as many predicted before.

Apparently 7 billion of us have 4 months to live

@statto That said, you are probably right about biological age tests - they seem to be of very poor quality at the moment.

@statto 1. You can be at a level that would be considered pretty good for a mid-20 year old. 2. But not at the level you'd need to be to be a professional athlete at the very top of a sport.

If Ronaldo’s biological age is mid-to-late 20s, why is he past his prime football years? Isn’t that many footballers’ peak? Oh yes it’s because measures of biological age are a useful research tool but clearly don’t cover every aspect of real age…

@statto Also, it's pretty clear that the extreme majority of the individuals associated with Epstein have neither an obsession, nor even an interest in longevity. By the same login, all the people who don't care about this cause are monsters now.

@statto What this woman says is crazy. "You are obsessed with escaping death if you have no respect for life", what? On the contrary, exactly the people who respect life - in the most part - want to prolong it and defeat ageing.

It’s very sad that longevity will be tainted by awful associations with Epstein. It’s not just creeps who don’t want themselves or their friends and family to get cancer and Alzheimer’s…but creeps and narcissists of course want to live longer, so longevity may well attract them