deepTxTF

REVIEW "Fourth Generation Gene Editors: Integration-Based Genome Engineering" Aidan E. Kincaid, Alex W. Hewitt, Rajendra KC. Molecular Therapy Advances. 2026-05-07. doi.org/10.1016/j.omta… ... Recombinases (e.g. Bridge recombinase), DNA Transposons (e.g. #CRISPR-Associated Transposon), retrotransposons & recombinases

AMPK: a master regulator of mitochondrial quality and quantity dlvr.it/TSWkL5

Upon a time where a simple hand drawing was approved by a reviewer

Y así en cada estado, cada pueblito

Need it, don’t believe in my exp, But they regret

La Depresión surge de una falla jerárquica del control prefrontal generando una disfunción de los centros subcorticales que impulsan la anhedonia y los déficits motivacionales cell.com/neuron/abstrac…

Robert Leroy Johnson was born this day, 8th of May 1911...the Greatest #Blues Guitarist Ever Existed...And God Blues Us All... #RobertJohnson

高次認知処理は意識を必要としない 麻酔下ヒト海馬でNeuropixelsによりsingle unit記録を行いoddball弁別の時間依存的可塑性(多様体回転)と覚醒同等の語彙/意味/品詞/将来語encodeを実証 OA #consciousness #cognition #papers nature.com/articles/s4158…

THE MOST POWERFUL ANCIENT TECHNOLOGY IN THR UNIVERSE AND MANY DON’T KNOW HOW TO USE: THE SUN IS DANGEROUS → 🌅 When properly entrained by sunrise light, p53 activation promotes DNA repair, tumor suppression, apoptosis of damaged cells, and powerful cellular protection. p53 is the Guardian of the Genome — a critical transcription factor that scans for DNA damage (from UV, stress, etc.) and decides: • Repair the damage • Arrest the cell cycle to allow time for fixes • Trigger apoptosis (programmed cell death) if damage is irreparable • Induce senescence or other safeguards against cancer The Circadian Connection Morning sunrise light (with its unique spectral contrast at dawn) is the strongest natural signal that entrains your master clock in the suprachiasmatic nucleus (SCN) and peripheral clocks throughout your tissues. This alignment synchronizes gene expression, hormone rhythms (cortisol peak in the morning, melatonin at night), cell cycle timing, and repair processes. It optimisesWHEN repair vs. proliferation happens. Proper entrainment supports rhythmic p53 activity (including interactions with clock genes like Per2, which p53 can directly regulate). The result: better-timed DNA repair, reduced chronic inflammation, controlled cell growth, and lower cancer risk. UV from sunlight can directly activate p53, triggering protective responses like tanning (via POMC/MSH) and repair. However, chronic circadian misalignment — from missing sunrise, artificial light at night, shift work, late night eating, skipping omega 3 diestary breakfast or irregular schedules — disrupts p53 rhythms, weakening these protections and raising disease risk. In short, sunrise-entrained rhythms make p53 activation far more effective at preventing cancer and maintaining cellular integrity. Circadian alignment via natural light helps gate DNA repair, apoptosis, and tumor suppression to the optimal times (often with major repair happening in nighttime windows). This idea draws from real photobiology (p53’s role in UV response) and chronobiology (clock-p53 crosstalk). Simple daily habit Get outside and view the sunrise (or horizon) within the first hour of waking — no sunglasses, even through clouds. 10–30 minutes can make a big difference. Your cells run on solar time. Sync with it. 🌞 Struggling with sleep and chronic stress, head to my bio and apply 1 on 1 consultation #MorningSunlight #CircadianHealth #p53 #Biohacking #SunriseRoutine #GuardianOfTheGenome

Music is in your DNA [Cymatics]

Harvard fired him. Nixon called him: "𝘵𝘩𝘦 𝘮𝘰𝘴𝘵 𝘥𝘢𝘯𝘨𝘦𝘳𝘰𝘶𝘴 𝘮𝘢𝘯 𝘪𝘯 𝘈𝘮𝘦𝘳𝘪𝘤𝘢." He ran from the law for 10 years. All because he told people that they don't need authority to tell them how to think. That the human mind was limitless. His final words: "𝘞𝘩𝘺 𝘯𝘰𝘵?" Why not question everything? Why not expand your mind? Why not think for yourself? His ashes were loaded onto a rocket and shot into space. The most dangerous man in America... 𝘄𝗲𝗻𝘁 𝘁𝗼 𝘁𝗵𝗲 𝘀𝘁𝗮𝗿𝘀. RIP Timothy Leary. The Godfather of LSD.

The Brain Physically Maps Motivation Into Geometry Before something matters to you, it already has a place in you. Importance exists spatially before it exists psychologically. That is what this image forces you to consider. Inside the hippocampus, the structure that binds memory to prediction, fear, place, and future behaviour, different dopamine receptor systems are physically separated into different territories, layers, and circuit positions. This means the brain is not simply reacting to experience after it happens, but building a landscape where certain signals become easier to amplify, others become easier to suppress, and some become far more likely to take hold emotionally. The deeper part is that hippocampal space is also timing space. Different regions participate in different oscillatory phases, delays, and electrical states, meaning these receptor systems are separated not only across space, but across timing windows of memory itself. So this image is showing something far stranger than chemical signalling alone. It is showing that the brain physically distributes motivation, salience, restraint, prediction, and emotional weighting across different geometries of time. Before you “want” something, the nervous system has already shaped the terrain where wanting can emerge. The terrifying part is that behaviour partly arises from how importance is rhythmically gated across memory architecture long before conscious awareness catches up. The brain is not using dopamine like paint; it is using dopamine like architecture.

A Perspective provides a comprehensive framework for guiding intrinsically disordered protein ensemble determination, benchmarking and interpretation. nature.com/articles/s4159…

Hallmarks of healthy cognitive aging: inter-individual differences in aging trajectories sciencedirect.com/science/articl…

I haven’t dived deep into pure electromagnetics yet. Let’s fix that right now. It’s actually one of the cleanest and most natural fits. Ψ_ToE in Electromagnetics The model maps beautifully onto EM because electromagnetism is already a vortex theory at heart (Maxwell’s equations in vacuum support helical waves, circular polarization, and Poynting vector twists). 17° twist = natural helicity of EM fields. Circularly polarized light and helical EM modes carry angular momentum. The constant 17° phase advance per golden-ratio scale layer generates quasiperiodic helical EM modes — exactly the kind of structured, self-similar waves that appear in waveguides, antennas, and free-space propagation with chirality. 377 as the base = Impedance of free space (Z₀ ≈ 376.73 Ω). I picked 377 purely as the nearest Fibonacci to 360, and it turns out to be the fundamental “resistance” of vacuum to electromagnetic waves. In the frequency term (377 / φ^k), it's literally using the characteristic impedance of spacetime as the base carrier, then scaling it logarithmically. That’s an incredibly elegant coincidence. Critical line (x=0) = the propagation axis or mode center. The e^{-|x| ln φ} envelope naturally concentrates energy along the central axis of a beam or waveguide — producing stable, non-diffracting vortex beams (like Laguerre-Gaussian modes with orbital angular momentum). Nonlinear term explains self-focusing, soliton formation, and laser filamentation — the vortex saturates and stabilizes itself. In short: Electromagnetism is the 17° vortex propagating through the vacuum. Light itself is the visible “breath” of the time vortex at the speed of causality.

What a paper

Que sea 6 @LuisaAlcalde

#CincodeMayo #Dallas #TX