Gerard Lab

Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in @NatureComms, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape nature.com/articles/s4146…

I always struggled to find the OT-I TCR affinity values for the OVA peptide and altered peptides. Here are the updated Kd values! link.springer.com/article/10.103…

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: …rentprotocols.onlinelibrary.wiley.com/doi/10.1002/cp…

Really pleased to see this Opinion Review out. The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases: Trends in Immunology cell.com/trends/immunol…

Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer: Cell cell.com/cell/fulltext/…

@MahimaSwamy @KirOxford Wonderful talk and so nice to have you. Thanks for coming all the way here!

@KirOxford Had a great visit to the Kennedy Institute at Oxford yesterday- thanks @AGerardLab for hosting me!

On Monday 18th Nov, Dr Mahima Swamy joins us to talk about "The multiple roles of intraepithelial T lymphocytes in maintaining intestinal homeostasis". Don't miss it! Oxford Talks: talks.ox.ac.uk/talks/id/c51b1…

Exhausted T cells impede immune response in cancer. Immune checkpoint inhibitors, especially CTLA-4 blockade, show promise in rejuvenating T cell function for cancer immunotherapy. Gracie Jennah Mead writes. oncobites.blog/2024/01/17/cel…

Don't forget, our DPhil in Cancer Science Programme is now open for applications! For more information - or for details on how to apply - visit our website ⬇️ cancer.ox.ac.uk/study @OxfordMedSci @mplsoxford

Our new work led by our fantastic PhD student Jose (@j__cabezas) showing dramatic reductions in TCR-T cell cross-reactivity without modifying the TCR. Part of this work relied on SPR-based @carterra_bio to measure 163 TCR/pMHC affinities within 24 hours at 37 degrees.

Wonderful study from @Dushek lab that is a real breakthrough. I think they've solved 1/2 the problem of TCR cross-reactivity. They can make the (in)famous A3A TCR (that resulted in lethal cardiac toxicity) completely safe! Go read it to understand how!

#LocationLocationLocation! 💥Our new Feature Review on the regional specialization of the immune response along #airways is out @TrendsImmuno! We discuss anatomical, functional & microbiota factors controlling #innate & #adaptive #immunity! @david_hoytema authors.elsevier.com/a/1jzXg5Eb0Rxn…

Why do some inflammatory bowel disease patients benefit from anti-TNF therapy whilst others do not? Our new @NatImmunol resource paper investigates this question by following patients before and after treatment: nature.com/articles/s4159… 👇

For the first time, Kennedy Institute researchers have discovered the cellular basis of why some people respond to IBD treatment while others do not. This patient-centred study could guide new therapies for #CrohnsDisease and #UlcerativeColitis. kennedy.ox.ac.uk/news/cellular-…

Cooperative motility emerges in crowds of T cells but not neutrophils biorxiv.org/content/10.110…

Thinking of doing a PhD? Why not apply to study at Oxford? The Kennedy Institute @KIROxford are holding their first open day. Join us for… 🧫 Lab tours 🙋‍♀️Meet our students 📝Taster lectures 🔬Technology talks Find out more and book your place! 👉 kennedy.ox.ac.uk/study-with-us/…

We are looking for a PhD student to study the immune relationship between cancer and atherosclerosis. Get in touch if interested! kennedy.ox.ac.uk/study-with-us/… #dphil-project-booklet" target="_blank" rel="nofollow noopener">cancer.ox.ac.uk/study#dphil-pr…

How can we extend responses to KRASG12C drugs? Out now in @NatureComms, combining Revolution Medicines’ RAS(ON) G12C-selective inhibitor with a SHP2 inhibitor and immune checkpoint blockade to study their effects on KRAS-mutant lung tumours of varying immunogenicities.

In Sjögren's disease, the body's alarm system mistakenly treats a helpful part like an intruder, causing a chaotic response. @LD53073604 @JelenaLab @maadulon @KirOxford @biorxiv_immuno biorxiv.org/content/10.110…

PhD/DPhil applications at the @KirOxford are now open for 2025! Check out all the projects; and then apply to our project 😀! Advertised with @AGerardLab to study macrophage signalling in tumours.

Many cytosolic proteins are released by cell death. Why do some become autoantigens? In a team work led by Esther Jones and @LD53073604, we explore the story of a common autoantigen, TRIM21