Anthony Orvedahl 🧬🦠🔬🩺🇺🇦

Our lab's first paper is out in the journal Autophagy @tandfonline! We found surprising differences in two common murine models of #cytokinestorm syndrome/ shock induced by #LPS and #TNF. bit.ly/3AUglxE. A 🧵: 1/n

Excited to share our paper identifying that bat coronavirus HKU5 uses ACE2 from its native bat host and American mink as a receptor. This highlights farmed mink has a high risk intermediate host for HKU5-like viruses. nature.com/articles/s4146… @YaleIBIO @YaleMed

🎉 Congrats to Michael D. Thompson of @WashU, 2025 Pilot Research Award in Liver Diseases awardee! His research explores how maternal diet may influence the risk of #biliaryatresia in offspring. #AASLD #LiverResearch #PediatricLiverDisease

Excited to share the finished version of this big project reporting a new mechanism of action for the E. coli alpha-hemolysin! pnas.org/doi/10.1073/pn…

youtu.be/mqn0is7alPI?si… RFK Jr. does not believe in the germ theory of infections.

Excited to share our new preprint, in which senior grad student Hunter Kuhn led our discovery of a novel mechanism by which E. coli hemolysin (HlyA) kills epithelial cells! (Spoiler: not by forming pores in the plasma membrane!) biorxiv.org/content/10.110…

Last week's @CytokineSociety #cytokines2024 meeting in Seoul was amazing! To celebrate, @SciImmunology has just released a free sample collection of papers highlighting the immunology of #cytokines! Articles are free online to read for the next 6 weeks! bit.ly/SciImm_free

Saddened by the news of Dr. Griffin’s passing. As a mentee of one of her mentees (Dr. Beth Levine), my own training and approach to scientific inquiry was profoundly influenced by her discoveries and approach to discovery.

Feeling the loss of Diane E. Griffin - brilliant physician-scientist who changed our thinking about host responses to viruses. Her calm leadership moved mountains seemingly effortlessly at home and around the world, all with poise, civility, humility and much joy.

Our preprint uncovering how endogenous retrovirus-like proteins reshape fundamental stress granule features is now online! So many awesome discoveries, the coolest being virus-like particles within stress granules! Cryo-CLEM work was led by Martin from @s_mosalaganti lab 1/8

@CytokineSociety @KAI_ImmuneNetw Update: our poster is Session 1, area 3, this evening (10/20)!

Looking forward to #Cytokines2024 in Seoul next week! If you want to learn about how immune signals are integrated to regulate Immune-regulated Gene 1 (Irg1) come see our unpublished results at our poster Sunday afternoon #P1-II005. @CytokineSociety @KAI_ImmuneNetw

The program for this meeting is exciting! #mitochondria #obesity #diabetes #mitochondrialdiseases #mitophagy #mitodynamics #mitotransfer #mitotransplants #mitomics and more Join us in St Louis next Juneby the Arch! #MitoMed 2025 @UMDF

Please excuse the terrible drawing. Done on an iPhone with no stylus!

@DiabetesNinja presenting to #PedsPI @WUSTLPeds about translational studies aimed at understanding patients with unusual forms of diabetes.

@horaniLab @WUSTLmed @Mill_lab Congrats!

Extremely excited and proud to see our paper on #cilia new variants in Science. This is a true international collaboration between many labs including @horaniLab at @WUSTLmed and @Mill_lab and many others. science.org/doi/10.1126/sc…

“I like infectious disease” ⬇️ “Oh shit student loans” ⬇️ “I like cardiology” ⬇️ Super bacteria destroys human race. Everybody dies with clean coronary arteries.

WHO statement on reported clusters of respiratory illness in children in northern China WHO has made an official request to #China for detailed information on an increase in respiratory illnesses and reported clusters of pneumonia in children. At a press conference on 13 November 2023, Chinese authorities from the National Health Commission reported an increase in incidence of respiratory diseases in China. Chinese authorities attributed this increase to the lifting of COVID-19 restrictions and the circulation of known pathogens such as influenza, mycoplasma pneumoniae (a common bacterial infection which typically affects younger children), respiratory syncytial virus (RSV), and SARS-CoV-2 (the virus that causes COVID-19). Authorities stressed the need for enhanced disease surveillance in healthcare facilities and community settings, as well as strengthening the capacity of the health system to manage patients. On 21 November, media and ProMED reported clusters of undiagnosed pneumonia in children in northern China. It is unclear if these are associated with the overall increase in respiratory infections previously reported by Chinese authorities, or separate events. On 22 November, WHO requested additional epidemiologic and clinical information, as well as laboratory results from these reported clusters among children, through the International Health Regulations mechanism. We have also requested further information about recent trends in the circulation of known pathogens including influenza, SARS-CoV-2, RSV and mycoplasma pneumoniae, and the current burden on health care systems. WHO is also in contact with clinicians and scientists through our existing technical partnerships and networks in China. Since mid-October, northern China has reported an increase in influenza-like illness compared to the same period in the previous three years. China has systems in place to capture information on trends in influenza, influenza-like illnesses, RSV, and SARS-CoV-2, and reports to platforms such as the Global Influenza Surveillance and Response System. While WHO seeks this additional information, we recommend that people in China follow measures to reduce the risk of respiratory illness, which include recommended vaccination; keeping distance from people who are ill; staying home when ill; getting tested and medical care as needed; wearing masks as appropriate; ensuring good ventilation; and regular hand-washing. WHO will continue to provide updates.

Watching this one closely... Link: promedmail.org/promed-post/?i…

Incredibly proud of my former @UTSWGradSchool student Christina Zarek and her paper in @PLOSPathogens!!! There is still so much to learn about the biology of #coinfection with #herpesvirus and #parasites!

Just updated: our massive database of funding opportunities for EARLY-CAREER RESEARCHERS/FACULTY. We have identified 496 opportunities. For each, we provide description, deadline, $ amount, and eligibility criteria. Download this database here: research.jhu.edu/rdt/funding-op…