@GioTufaMD @SanRaffaeleMI @giovannilandoni I am happy to answer any questions and participate online if it feasible with my clinical work. If you have any questions when you prepare your JC I am available on ncan@regionsjaelland.dk
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Nina A-Ranberg
91 posts
Nina A-Ranberg
@ARanberg
MD, PhD student, Research in Intensive Care
Katılım Eylül 2018
88 Takip Edilen164 Takipçiler
@ARanberg Hi, in march I will show a JC to our colleagues about #AIDICU trail. We're from @SanRaffaeleMI. The presentation will be in dual mode, if you are interested to explain something else it would be a pleasure. Let's keep in touch if u are interested. @giovannilandoni
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1/9
#AIDICU trial results on haloperidol vs. placebo for the treatment of delirium in ICU patients @NEJM
Amazing work in 16 ICUs 🇩🇰🇫🇮🏴🇮🇹
Funded by
@Innofond
@regionsjaelland
@regionerne
nejm.org/doi/full/10.10…
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Dansk
@MarkOldhamMD @devlinpharmd @PharmDuprey @timothygirard We are currently working on functional (IADL, ADL) and cognitive (RBANS) data from AID-ICU participants assessed at one-year follow-up. Lastly, we will investigate heterogeneity of treatment effect further in collaboration with american colleagues. So more data is on its way!
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@MarkOldhamMD @devlinpharmd @PharmDuprey @timothygirard Summarised data for mortality from 4 RCT of haloperidol vs. placebo used to treat delirium is available here: ccforum.biomedcentral.com/articles/10.11…
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I couldn't resist. 🤣
Provocative data, clearly, but I agree w/ @devlinpharmd @PharmDuprey @timothygirard that we should NOT increase "use of haloperidol to treat delirium until additional research clearly determines [its] long-term outcomes."
Editorial: bit.ly/42sUPxq
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Nina A-Ranberg retweetledi
📋 1-year analysis of AID-ICU RCT (n = 1000) reports provocative (or promising?) finding of survival benefit with #haloperidol for ICU #delirium. 🤔
🔗 Link: doi.org/10.1007/s00134…
📎 Primary (@NEJM) & prior Bayesian analyses here: x.com/MarkOldhamMD/s…
🎩/t @carlos_arnaud
Mark Oldham@MarkOldhamMD
Secondary Bayesian analysis of the AID-ICU trial (n = 1000, primary results in @NEJM) finds very high likelihood of benefit & extremely low likelihood of harm with haloperidol for ICU #delirium. Bayesian analysis: doi.org/10.1007/s00134… Primary results: nejm.org/doi/full/10.10…
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Long-term outcomes of the AID-ICU trial now available online👇
@CRIC_Int_Care
@SUHhospital
@MusaeusPoulsen
@ole_mathiesen
@AndersPerner
@andersgranholm
@Innofond
Intensive Care Medicine@yourICM
Haloperidol vs placebo in acutely admitted critically ill adults with delirium, follow-up of AID #ICU trial 💉treatment with haloperidol reduces long-term mortality but doesn't appear to improve longterm outcome of health-related quality of life #FOAMcc 🔓bit.ly/3tEmeiU
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Nina A-Ranberg retweetledi
Thrombocytopenia in #ICU, PLOT‑ICU study
🩸observed in 43% critically ill adults associated with worse outcomes (½ at admission, with increased mortality)
🩸PLT transfusions frequently used (23%) if severe/very severe thrombocytopenia, most prophylactic
🔓bit.ly/3LQTj0Q
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In great company with @timothygirard and @AndersPerner we discuss #AIDICU and #MINDUSA and the current evidence we have for the effects of haloperidol in ICU patients with delirium. Go read👇
Intensive Care Medicine@yourICM
💉 Haloperidol & #delirium? Despite new data, uncertainty remains. Is best-studied antipsychotic in #ICU: safe, easy to administer/titrate + better supported by evidence vs others, but do NOT forget to implement nonpharmacologic interventions! #FOAMcc 🖇️ rdcu.be/dnLXQ
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Tomorrow, I will defend my PhD. Everyone is welcome! Should be available online by joining the team-meeting but tech-support is low🍀
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Nina A-Ranberg retweetledi
Are you an MD or med student interested in evidence-based medicine, clinical trials, or stats/methods?
HELP us assess how different statistical approaches affect clinical trial interpretation here: redcap.link/RE-PRESENT (10-20 min)
Shares & retweets much appreciated!
Anders Granholm@andersgranholm
Are you an MD or med student interested in evidence-based medicine? Join the RE-PRESENT survey-based trial at redcap.link/RE-PRESENT (10-20 min) to help us learn how different statistical approaches affect clinical trial interpretation. Responses/shares greatly appreciated!
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@arthur_alb1 @AndersPerner Thanks Arthur. The method described by Jacobsen et al. lie between full bonferoni correction which we find to conservative as outcomes like SAEs and mortality are typically interdependent and no correction which is too loose.
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@ARanberg Nice work, Nina, @AndersPerner, and colleagues! Strong pre-registered protocol.
May I ask why you chose to apply the Bonferroni correction (based on Jakobsen's suggestion bmcmedresmethodol.biomedcentral.com/articles/10.11…) instead of more flexible methods, such as multivariate models?
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Our updated systematic review assessing the effects of haloperidol on mortality and serious adverse events in critically ill patients with delirium is now available online. Data from #AIDICU #EuRIDICE trials are included with existing treatment trials👇
link.springer.com/article/10.118…
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@arthur_alb1 @AndersPerner Are these the methods you suggests? I am not familiar with these methods but looks interesting.
…maticreviewsjournal.biomedcentral.com/articles/10.11…
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Nina A-Ranberg retweetledi
Haloperidol to treat delirium in the ICU: a meta-analysis
Mortality: 5 RCTs with 1553 pts
Haloperidol🆚placebo
RR 0.89; 96.7% CI 0.77 to 1.03
No significant between-group differences in
- serious adverse events/reactions
- days free from delirium
🔓rdcu.be/dkwAU
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Nina A-Ranberg retweetledi
First fluid trial in septic shock patients including longterm outcomes and with only 8.7% missing data, thanks to all collaborators!
Intensive Care Medicine@yourICM
💦 Restricting IV fluids in adults with septic shock in #ICU: analysis of CLASSIC trial. Restriction resulted in similar survival, HRQoL, cognitive function at 1 year vs standard therapy but clinically important differences could not be ruled out #FOAMcc 🖇️rdcu.be/deP7j
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Nina A-Ranberg retweetledi
Days alive without life support and similar composite outcomes are popular in critical care RCTs.
Here is an updated take on these outcomes led by @andersgranholm!
rdcu.be/deRK9
@AndersPerner @f_g_zampieri @benskov @LangeTheis @marie_warrer @MortenHylander @INCEPTdk
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Nina A-Ranberg retweetledi
💦 Restricting IV fluids in adults with septic shock in #ICU: analysis of CLASSIC trial. Restriction resulted in similar survival, HRQoL, cognitive function at 1 year vs standard therapy but clinically important differences could not be ruled out
#FOAMcc
🖇️rdcu.be/deP7j
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@UHWResearch @dr_mattmorgan @judith_white3 @Cedar_Cardiff @UHWCriticalCare Thank you for your participation and hard work in the AID-ICU trial
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Brilliant day with @judith_white3 from @Cedar_Cardiff hearing the results of fantastic critical care trials being presented at #CCR23 🤓
Really proud to see the results of the AID-ICU trial presented after @UHWResearch and @UHWCriticalCare worked so hard recruiting patients 👏🏻👏🏻
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I’m here at @CritCareReviews and looking forward to discuss the results of the AID-ICU trial with colleagues from all over the world today at #CCR23
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