Aaron E Lin

56 posts

Aaron E Lin

Aaron E Lin

@Aaron_E_Lin

Postdoc, @bsadamson & @PlossLab labs, @Princeton. @DamonRunyon Fellow. PhD in Virology, @sabeti_lab, Harvard & Broad.

Katılım Eylül 2016
213 Takip Edilen196 Takipçiler
Aaron E Lin retweetledi
Ann Cirincione
Ann Cirincione@AnnCirincione·
Thrilled to see our work out in @naturemethods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.
Nature Methods@naturemethods

From @bsadamson and colleagues, a prime editing platform for high-throughput functional interrogation of up to tens of thousands of small genetic variants. nature.com/articles/s4159…

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Sofi Quinodoz
Sofi Quinodoz@sofiquinodoz·
Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…
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Dylan Kotliar
Dylan Kotliar@DKotliar·
We are so excited to share a project that started before my MD/PhD (over 10 years ago) and comes out today in @NatureMicrobiol titled “Genome-wide association study identifies variants associated with fatal outcome from Lassa fever” rdcu.be/dx2Wq
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Sergio Triana
Sergio Triana@shtriana·
We are thrilled to present our work delving into the molecular basis of Ebola virus disease across time! We established an extensive viral genomic and host transcriptomic dataset from a natural history study of 21 NHPs exposed to a lethal dose of EBOV. cell.com/cell-genomics/…
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Aaron E Lin
Aaron E Lin@Aaron_E_Lin·
@NeuroLuebbert @PardisSabeti @RobertEdgarPhD @RNA_Life @DKotliar And @LisaEHensley1 too! Actually, many folks in @sabeti_lab just published a follow-up study with bulk RNA-Seq for a dozen tissue samples from the same animals — would be SUPER cool to see if there’s similar viral seqs in tissues x.com/shtriana/statu…
Sergio Triana@shtriana

We are thrilled to present our work delving into the molecular basis of Ebola virus disease across time! We established an extensive viral genomic and host transcriptomic dataset from a natural history study of 21 NHPs exposed to a lethal dose of EBOV. cell.com/cell-genomics/…

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Laura Luebbert, PhD
Laura Luebbert, PhD@NeuroLuebbert·
But wait! What about the host sequences? We describe a total of 8 different workflows for the masking of host sequences. We found that many viruses, including known infections, will have some reads that also align to the host, making this a complicated issue.
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Laura Luebbert, PhD
Laura Luebbert, PhD@NeuroLuebbert·
We expanded kallisto to translated alignment (nucleotides <-> amino acids), and used it to detect novel viruses in RNA seq data. The single-cell resolution allowed us to determine whether the presence of these viruses affected host gene expression. 🧵 biorxiv.org/content/10.110…
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Princeton University
Princeton University@Princeton·
More like the Guardin' State! 🧡 🖤 Congratulations to @PrincetonMBB who moves on to the Sweet 16 after a 78-63 victory over Mizzou! Go Tigers! #MarchMadness
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Bill Gates
Bill Gates@BillGates·
.@PardisSabeti is working to detect pathogens earlier and stop pandemics in the their tracks.
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Nicole Welch
Nicole Welch@NicoleLWelch·
The mCARMEN Accelerated Article Preview is live on Nature Medicine!! (with data tracking the Omicron wave!) Check it out ⬇️ doi.org/10.1038/s41591…
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sabeti_lab
sabeti_lab@sabeti_lab·
Happy Holidays from Sabeti Land! Wishing you countless moments of joy and light throughout 2022!
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Kim Lagerborg
Kim Lagerborg@KimLagerborg·
Excited to share our newest publication “Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows”. Out in Nature Microbiology today! (1) nature.com/articles/s4156…
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Keşfet

@naturemethods @KeithBerggren @RobSchwartzLab @Crittermechanic @KleinerLabRNA @PrincetonMolBio @NCStateVetMed @Princeton