Alessandro Bonetti

🎤Don’t miss Alessandro Bonetti @AleBon78 at @CamBiochem the 20 Mar. at the RNA Club He'll dive into the fascinating world of lncRNAs, explaining why they're such exciting therapeutic targets and how his pioneering work with RADICL-seq is uncovering new insights into RNA biology

Hiring! We are seeking for highly motivated scientists for a remote Junior Bioinformatician position. ScitoVation is a premier startup company with the mission of developing approaches to understand the impact of small molecules & chemicals on our health. tinyurl.com/7y9p2dt4

@tim_warwick @Schwalbe_BMRZ @TheMarcelSchulz @AnneDueck @lara_althaus @JamesAOo7 @Ralf_P_Brandes @BrandesLab @trr267 @CPI_ExStra @dzhk_germany @dfg_public Very well done, Tim! It has been truly a pleasure being part of this work.

This research was a pleasure to be a part of! Huge thanks go to all the co-authors @Schwalbe_BMRZ @TheMarcelSchulz @AnneDueck @lara_althaus @JamesAOo7 @AleBon78 @Ralf_P_Brandes @BrandesLab and funding sources @trr267 @CPI_ExStra @dzhk_germany @dfg_public! (7/9)

Ever wondered what determines RNA-DNA interactions? We set out to learn RNA:DNA:DNA base pairings from triplex-sequencing data, and the findings are out in @OxfordJournals Briefings In Bioinformatics doi.org/10.1093/bib/bb… with @TheMarcelSchulz @Schwalbe_BMRZ @BrandesLab! (1/9)

@muju79 I remember that bottle 😀... Absolutely well deserved and huge congratulations 🎉. An incredible tour de force from an extremely talented colleague!

7 years ago someone brought this bottle to a home party, it was left unopened so I put it on my office desk and I promised to open it only when my paper was going to be accepted. Well…time to see if this thing has turned into vinegar because GUESS WHAT, PAPER ACCEPTED🎉🥳🎊🍾!!!

Researchers have designed an #mRNA vaccine that delayed the onset of and reduced the severity of multiple sclerosis-like disease in mice. The vaccine restores the body’s tolerance to its own proteins, suppressing the disease's immune overreactivity. ($) fcld.ly/s6xsa24

Do you also feel like saying after paper rejection: "Hello, my name is Yossi Buganim, you killed my paper prepare to die!" Or is it only me? 🤔

We are recruiting. If you are a computational biologist interested in single-cell analysis and transposable elements then apply now! Great team and great conditions @Lund_Stem. Please RT! nature.com/naturecareers/…

@KraftKaterina @doctorcorces @JeffreyGranja May I ask which fancy tube rotators are you talking about?

6/n @doctorcorces and @JeffreyGranja thank you for the loop pipelines! and help in the lab (Ryan's fancy tube rotators definitely improved digestion/ligation)

1/n We are excited to share our preprint: Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylation biorxiv.org/cgi/content/sh… #bioRxiv Fantastic collaboration with cool PhD students and postdocs from great research groups:

Proud to have taken part in a project with so many possible biological implications! It's been a long journey on a very bumpy road but only the mix of talent and resilience from @muju79 made it possible. Great work Giovanni!

@OdedRechavi Why the dude was wearing a protective helmet at lower speeds but then decided to give up for higher speeds? What’s the physiological relevance?

Incremental advances twitter.com/TheoShantonas/…

@ShechnerLab @donelson_smith I always thought of RNase Zap as a homeopathic remedy. I cannot agree more about physical separation of bacterial preps and RNA work.

@donelson_smith Homemade “RNase Zap”: 0.1 N NaOH 0.1% SDS Use liberally.

Name your best tips/tricks/readings for deconning a lab space to make it ready for #RNA work @ShechnerLab and anyone else!

Perspective written with the talented @nataliepapanic on the functional characterisation of noncoding variants associated with common diseases and future therapeutic targets. tinyurl.com/y7qxdrqt

@Noncodarnia @RNASociety @IgorUlitsky @stojic_lovorka Nice talk! Have you considered to use rChIP to test how the DNA binding of selected TFs is affected upon RNase treatment? For example Sox2...

An interesting new role for nucleolar-centromere contacts: regulation of satellite DNA transcription. A fun collaborative project with Leah Bury (@BuryLeah), Brittania Moodie, Liliana McKay, and Iain Cheeseman (@iaincheeseman).

Yay - our paper on Structure-mediated RNA decay (SRD) is officially out! We discovered a new paradigm to read RNA. Instead of defined sequence or structure, SRD detects density of RNA base-pairing. SRD works in both coding and noncoding RNAs. Free access: authors.elsevier.com/a/1aqog3vVUPDd…

Some scientists looking at left-handed DNA twitter.com/ChronicOG_2nd/…

Molecular biologist thinking he’s an epidemiologist twitter.com/TayyabaWaqas94…

Very excited to share our 1⃣st publication from the lab - the development of near PAMless CRISPR-Cas9 variants. Huge congrats to @russelltwalton (🙌), @katieachristie, and @mn_whittaker for their tireless work. Brief thread 👇. #CRISPR #druggablegenome science.sciencemag.org/content/early/…

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