Alessandro Lacedra

With God on our side - Bob Dylan youtu.be/5y2FuDY6Q4M?si…

🚨BREAKING: Google just launched CodeWiki, and it might be the biggest upgrade GitHub has had in years. You paste your GitHub repo in, and it turns your entire project into an interactive guide. It also generates diagrams, explanations, walkthroughs, everything you could ever want, and even a chatbot that knows the code better than anyone else.

Harvard found that GLUTEN makes EVERY human gut leak — within hours. YOU included. celiac or not. (Drago et al, Scand J Gastroenterology 2006. PMID: 16635908) Alessio Fasano discovered zonulin — the protein that opens the tight junctions in your gut wall. gliadin triggers it. every time. in every gut. mechanism: gliadin → zonulin release → ZO-1 disassembly → tight junctions open → bacterial endotoxin crosses into your blood → inflammation rises. that’s the LPS Loop, triggered by your sandwich. the difference between you and a celiac isn’t whether your gut leaks. it’s how long it stays open. – celiac: hours of permeability per exposure. chronic, severe inflammation. – non-celiac sensitivity: extended permeability + measurable symptoms. – “healthy” person: transient permeability, accumulating subclinical inflammation over years. you’re not safe. you’re slower. what years of “healthy” gluten exposure looks like: – chronic low-grade inflammation – food sensitivities multiplying – brain fog, joint pain, fatigue nobody can explain – autoimmune conditions emerging in the genetically predisposed your gastroenterologist will tell you that if your celiac panel is negative, you’re fine. Fasano’s own research says otherwise. three fixes: 1. test before you assume — anti-tTG IgA + total IgA. zonulin if your provider runs it. 2. if you’re keeping gluten, switch to long-fermented sourdough — traditional fermentation breaks gluten peptides down. 3. if you have autoimmune symptoms, run 60 days strict gluten-free, then reintroduce. trust your body more than the panel. if you have bloating, joint pain, or brain fog despite “eating clean” — your bread is doing something your blood test can’t see.

As a medical school professor, I'm watching fructose emerge as a key driver of metabolic disease -- and most people have no idea their body is making it. A new Nature Metabolism review by Dr. Richard Johnson at the University of Colorado Anschutz argues fructose is uniquely harmful. Unlike glucose, it bypasses regulatory steps in the liver, depletes ATP, and drives fat synthesis through a different pathway. Even more striking: when blood sugar is high, your body converts glucose into fructose internally. A note on study design: this is a narrative review and mechanistic synthesis -- not a randomized trial. It pulls together animal data, cell studies, and observational evidence. It does not prove fructose causes human disease through diet alone -- that requires interventional trials. Fructose may be one of the cleanest examples of metabolic dysfunction as the root cause of chronic disease -- linking obesity, fatty liver, type 2 diabetes, hypertension, and even Alzheimer's risk through a shared pathway. Full breakdown coming on the Health Longevity Secrets podcast @RobertLufkinMD" target="_blank" rel="nofollow noopener">youtube.com/@RobertLufkinMD Source: eurekalert.org/news-releases/… #MetabolicHealth #Fructose #Longevity #FattyLiver #HealthLongevitySecrets

Here’s something odd. Despite the expressed certainty that high LDL is a primary cause driver of atherosclerosis, with claims like “there’s no safe level of high cholesterol” regardless of metabolic state, when I present what seems my own clear-cut case of having a total cholesterol of 700 for nearly 7 years, and then ask a simple question: How much plaque will be in my arteries? Almost nobody guesses: “a lot.” Now, to be clear, this isn’t just a basic coronary artery calcium scan I'm getting. I recently underwent an advanced coronary CT angiography, with expert-guided interpretation and AI-based quantification down to the cubic millimeter (mm3). Of note, people in their 20s and 30s often do show plaque on these scans, including some well-known nutrition influencers. One example that comes to mind is someone in the plant-based community, in his 30s, with a total plaque volume of 61.3 mm³. So I come back to the question: 👉How much plaque will be in my heart? 👉And why does it seem that no one wants to guess “a lot”? These aren’t results I could possibly fake.

This article came out in @Telegraph this morning, and it’s already gaining significant traction, apparently reaching top three on the site within hours or release. telegraph.co.uk/health-fitness… There’s clearly a lot of engagement, so since I won’t be able to respond to every comment, I want to clarify a few things upfront. First, I am not, nor have I ever been, anti-pharmacotherapy. What I am against is a lack of nuance. I don’t believe it’s my place to say something as simplistic as “X drug is overprescribed,” (some editorial liberties were taken). However, my concern is that they are prescribed without sufficient individualization and thoughtfulness. My critique is not of pharmaceuticals themselves, but of a system that too often operates algorithmically, rather than with the precision each patient deserves. Having personally experienced the downsides of that kind of care (multiple times), I feel comfortable speaking to it with the authority of a patient, MD PhD or not. Second, I did not request, solicit, or pay for this article in any way. I was approached for it just as I was for an upcoming lecture at the @UniofOxford Longevity Summit, hosted at Rhodes House this weekend. I did no approaching, nor do I get any sort of kickbacks. Third, this is not an article I wrote, nor is it intended to be an academic dissertation. If you’re looking for deeper nuance, I’d encourage you to explore my broader body of work, on YouTube or through my Substack, which covers dozens of articles on heart health and synthesizes hundreds of studies and human trials. staycuriousmetabolism.substack.com/p/hearthealth And thanks for making is #2 Overall Best-Selling in Science on Substack, Globally. That's heartening :). But I’ll leave you with this: What is a consensus worth… when the status quo it represents has failed to meaningfully improve public health?

Italy has a famously low birth rate. This map is a rather wild way of showing that. We see the last year of natural increase (more births than deaths) in each Italian region. Source: reddit.com/r/MapPorn/comm…

@Jaffer22915438 The Roman army rule: action removes fear.

Nothing is more harmful to a man than his resistance to grace. - Ven. Fulton Sheen

Terminando de assistir Além da Linha Vermelha (1998) pela quinta vez. Esse é o filme mais subestimado de todos os tempos? >um filme de guerra que não é sobre guerra >Jim Caviezel faz um soldado cristão (Witt) >Sean Penn faz um soldado ateu (Welsh) >os dois conversam constantemente >em meio à guerra, Witt contempla a natureza, observando o mistério e a beleza da Criação >Welsh, completamente cético, não compreende isso e o questiona constantemente >os diálogos são incríveis >as cenas de batalha e a fotografia são incríveis >a trilha sonora é maravilhosa >recebeu 7 indicações ao Oscar >Martin Scorcese disse que esse é o segundo melhor filme dos anos 90 Um dos melhores filmes de todos os tempos e quase ninguém fala sobre ele.

Rory Sutherland made a sharp observation about why so many smart people struggle with real life decisions. On Andrew Gold’s Heretics podcast, he blamed part of it on our education system. From school exams to intelligence tests, we’re trained on problems that have one clear right answer and all the information neatly provided (like the classic “two buses leave the station” math problem). But real-world choices — who to marry, where to live, what career to pursue, even what sofa to buy — are nothing like that. Information is incomplete, messy, sometimes deliberately misleading, and there’s rarely a single “optimal” answer. Some of the smartest people he knows (including his astrophysicist brother) get paralyzed in places like IKEA because there’s no algorithm to optimize the decision. This matters because we’re educating people to excel at artificial problems while leaving them unprepared for the ambiguous, high-stakes decisions that actually shape their lives. This one landed hard. I’ve caught myself overthinking simple choices because I was waiting for that perfect, single right answer that school trained me to look for. Real life is rarely that clean. This one landed hard. I’ve caught myself overthinking simple choices because I was waiting for that perfect, single right answer that school trained me to look for. Real life is rarely that clean. What’s a decision you’ve struggled with because there was no clear “right” answer?

Some fields work in theory but not in practice. Some fields work in practice but not theory. The uniqueness of economics is that it works in neither theory nor practice.

🚨Gazze'de açıklama yapan Avustralyalı kadın doktorlar: ▪️Bu videoyu çekiyoruz çünkü her an ölebiliriz. ▪️Hastalarımızın %70-80'i çocuk ve hamile kadınlar. ▪️9 aylık hamile, başı kesilmiş bir kadını doğurttum. ▪️Lütfen bu terör ve dehşeti durdurun.

The Jesuits had a document called the Ratio Studiorum It was written in 1599 and governed exactly how a student was to be taught, corrected, examined, and failed Not what to teach, but how formation actually worked: the sequence, the standard, the consequence of not meeting it That kind of structure assumed that a student left different from how he arrived Not just more informed 🧵

Albert Einstein once remarked, “You know, Henri, I began by studying mathematics, but eventually turned to physics.” Henri Poincaré asked, “Why was that?” Einstein replied, “Because although I could distinguish true statements from false ones, I couldn’t determine which were truly important.” Poincaré smiled and responded, “That’s quite interesting, Albert. I began with physics, but ultimately chose mathematics.” Einstein, intrigued, asked, “And why did you make that change?” Poincaré answered, “Because I couldn’t tell which of the important facts were actually true.” The exchange captures, with subtle wit, the contrasting philosophies of two of the greatest scientific minds.

“There is a self-hatred in the West that can be considered only as something pathological. The West attempts in a praiseworthy manner to open itself completely to the comprehension of external values, but it no longer loves itself; it now only sees what is despicable and destructive in its own history, while it is no longer able to perceive what is great and pure there.” — Cardinal Joseph Ratzinger (Pope Benedict XVI), “The Spiritual Roots of Europe”

Joe Blitzstein at Harvard explaining Bayes' theorem - the math behind every prediction market sniper The market gives you a prior. The real data gives you a posterior. The gap between the two is where money lives. That's the entire framework the bot above is running on weather contracts 1 hour from one of the best stats lecturers in the world Bookmark and watch ↓

employment in 2050 like

Day in the life of a solopreneur who makes $77k per month:

MIT just quietly dropped a free AI curriculum that puts $50,000 university courses to shame. 12 books. Zero tuition. From the same institution that produced the people building the models everyone is talking about. FOUNDATIONS 1. Foundations of Machine Learning — lnkd.in/gytjT5HC 2. Understanding Deep Learning — lnkd.in/dgcB68Qt 3. Machine Learning Systems — lnkd.in/dkiGZisg ADVANCED TECHNIQUES 4. Algorithms for ML — algorithmsbook.com 5. Deep Learning — lnkd.in/g2efT6DK REINFORCEMENT LEARNING 6. RL Basics (Sutton & Barto) — lnkd.in/guxqxcZZ 7. Distributional RL — lnkd.in/d4eNP-pe 8. Multi-Agent Systems — marl-book.com 9. Long Game AI — lnkd.in/g-WtzvwX ETHICS & PROBABILITY 10. Fairness in ML — fairmlbook.org 11. Probabilistic ML Part 1 — lnkd.in/g-isbdjj 12. Probabilistic ML Part 2 — lnkd.in/gJE9fy4w This is a complete MIT-level AI education. Not a YouTube playlist. Not a Twitter thread full of fluff. Textbooks written by the researchers who built the field. The people who actually study this will not just understand AI better than their peers. They will understand it better than most people currently getting paid to work in it. Most people will bookmark this and never open it. The ones who open it tonight are the ones who show up in 12 months having built something nobody around them understands yet. Bookmark this. Open the first one tonight. Follow @cyrilXBT for more resources that actually compound.

Scientists have created one of the most detailed 3D reconstructions of a human cell (eukaryotic cell) ever produced. This groundbreaking model, often termed a "Cellular Landscape Cross-Section Through a Eukaryotic Cell," combines data from X-ray tomography, nuclear magnetic resonance (NMR), and cryo-electron microscopy to map molecular structures in extreme detail.