Alexander Hanzl

Following the general trend (for good reasons) I can now be found on: bsky.app/profile/alexan… Good riddence.

In back to back preprints from @arcinstitute, the labs of @LukeGilbertSF and @pdhsu present two distinct platforms (COMET and COMBINE) for systematically exploring combinations of protein domains, each of which yielded a diverse range of CRISPR-guided transcriptional effectors with features unique from CRISPRa/i. Both the platforms and the domain combinations have the potential to expand the toolbox for control of transcription and chromatin states and provide frameworks for screening combinatorial domains in other contexts. Check out the preprints: biorxiv.org/content/10.110… biorxiv.org/content/10.110…

How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on.. Paper @ImmunityCP: authors.elsevier.com/c/1js3h3qNrUxu…

Excited to share our latest preprint. Lead by Sevi (@biosevi) we asked how transcription factors (TFs) with short and abundant motifs drive specific cell fates. Our test cases: Two bHLH factors that bind to seemingly similar E-boxes. 1/7 biorxiv.org/content/10.110…

I am so happy to share our story on supercharging kinase degradation, now live on biorxiv! Thanks to everyone involved in this project. Check out the 🧵👇

🔬 Targeted Protein Degradation: A new adapter molecule expands the therapeutic potential around the cell's waste disposal system, CeMM PI @georg_e_winter's team published a new study in @NatureComms : go.nature.com/3zn9Ia2 Read more ➡️ bit.ly/4cmwYn6

☕️In this issue: Kubicek & co report a method for multicolour tagging using genome-scale intron-targeting sgRNA libraries that, in combination with computer vision, enables the systematic detection of protein localization changes. nature.com/articles/s4155…

Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110… #2: biorxiv.org/content/10.110…

@RPNowak @IsbBonn @UniklinikBonn @UniBonn @ImmunoSens Congrats Radek, great to have you in the closer vicinity!

NEWS! I'm excited to share that I'm joining @IsbBonn @UniklinikBonn @UniBonn @ImmunoSens as a professor to start my LAB! We are open for business and #hiring for #postdoc #tech positions! #NewPI #MoveToGermany #UniBonn #TPD #InducedProximity Please share! nowak-lab.com

Thank you very much to the Austrian Life Science Association ÖGMBT. It is a great honor to receive this award and wouldn't have been possible without the whole @georg_e_winter lab and our collaborators @alessiociulli @fischerlab1

@FerreiraSilvaJ @connorjtou Congrats Jo!

Today in @bioRxiv, we describe Click Editors (CEs) which combine DNA-dependent DNA polymerases, HUH endonucleases and RNA-programmable nickases for versatile genome editing without double-strand breaks 🧬. A study co-led with @connorjtou. A 🧵 (1/14): biorxiv.org/content/10.110…

@LabThoma @alessiociulli @georg_e_winter Thanks Nico for the great summary. Enjoyed the read a lot!

Delighted to share our spotlight on a beautiful paper by @alessiociulli and @georg_e_winter. Alex Hanzl and colleagues combined structural and biochemical techniques with deep mutational scanning to identify residues crucial for degrader activity. nature.com/articles/s4158…

Our paper on 14-3-3 proteins and their role in protein aggregation and phase separation is out! This paper represents the main PhD thesis work by my student Dmitri Segal. 1/ cell.com/molecular-cell…

Thrilled for our Orpinolide story to see the light of day! Huge thanks to the @georg_e_winter lab, Waldmann lab, @laraialab and everyone that contributed @HanaImrichova, @FabianFrommelt, @Laura_dta, Andrea, @CKagiou, Thomas, @CrisMayorRuiz, @gsf_lab and Sonja Sievers! 🧵👇

A paper from @cemm_news @gsf_lab @PEssletzbichler @giuliosf uses genome-wide FACS based reporter screening to generate a broad view of the molecular network regulating phagocytosis in human cells. life-science-alliance.org/content/6/4/e2…

@FerreiraSilvaJ @BKleinstiver Congrats Jo!

Incredibly grateful for this recognition and excited to continue our work in the @BKleinstiver Lab!! 🧬👩🏻‍🔬

Our study on structural rationale for GSPT1 and IKZF1 degradation with close IMiD analogs just published. We looked at the effects of amino and hydroxy-substitutions on cellular CRBN engagement, IKZF1 and GSPT1 degradation.#thalidomide #CRBN #molecularglue tinyurl.com/28c6jsvk