Ali D. Güler

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/

A neural circuit through which small-molecule GLP1RAs modulate reward processing, with implications for the treatment of substance-use disorder and binge eating @Nature @deppmann @GulerLab @LizzieGodschall @bugragungul @isabellesajonia @UVA nature.com/articles/s4158…

NEWS: Oral small-molecule GLP-1 drugs penetrate deep into the brain to suppress cravings. 🧠 Read the full story ➡️ nih.gov/news-events/ne…

Now out in peer-reviewed form: nature.com/articles/s4158…

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/

A recent Northwestern Medicine study led by Lisa Beutler, MD, PhD, assistant professor of Medicine in the Division of Endocrinology, Metabolism and Molecular Medicine, identified novel neural circuits modulated by the diabetes and obesity medications semaglutide and tirzepatide that help suppress appetite. Hear Dr. Beutler explain these findings further: lnkd.in/g2pHhjxy

@AliDGuler @uvabio @UVA Come and join us: neuroscience.virginia.edu

At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more… in beautiful Charlottesville, VA. Apply today & help shape the future of neuroscience: apply.interfolio.com/172892 #Biology #UVA

We welcome applicants working on: • Neural circuits & plasticity • Glia & brain interactions • Behavioral genetics & genomics …and more! Join a highly interdisciplinary dept with access to state-of-the-art imaging, genomics, metabolomics, and computing resources. #NeuroJobs

We’re hiring! @uvabio @UVA_PFN @UVA UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. Apply by Oct 15, 2025. Start Aug 2026. apply.interfolio.com/172892 #Neuroscience #FacultyJobs

LUKE KORNET TONIGHT — 10 POINTS 9 REBOUNDS 7 BLOCKS 100% FG GAME OF HIS LIFE. 🔥🔥🔥🔥

Take the leap, it's easy bsky.app

A dedicated neural circuit through which small molecule GLP1RAs modulate reward processing, suggesting broad therapeutic potential in conditions of dysregulated dopamine signaling including substance use disorder and binge eating pubmed.ncbi.nlm.nih.gov/39763823/

It turns out today is the humanized "Glp1rS33W" rodent model day. Here is another one published today by Eli Lilly and Company @EliLillyandCo science.org/doi/10.1126/sc… Didn't know... we could have had a party 😉🥳🎉

Our collaborative team at UVA Biology Department @uvabio including the labs of Chris Deppmann @deppmann and John Campbell @AUGCsoup are awesome. They all made it fun!