T. Bugra Gungul

Nature research paper: A brain reward circuit inhibited by next-generation weight-loss drugs in mice go.nature.com/4uUbvuX

Out in Nature today: how next-gen GLP-1 drugs cut cravings, not just hunger. Congrats to co-first authors Lizzie, Bugra, and Isabelle in @GulerLab lab traced the circuit — drug → central amygdala → less dopamine in reward circuits. Mostly Ali's lab; we got to contribute. Proud of this team. rdcu.be/fhfOm #neuroscience #UVA

Discovery of a new brain reward circuit in the amygdala for small molecule (pill) GLP-1 drug effect, unlike the injectables (hypothalamus), as shown in mice nature.com/articles/s4158…

NEWS: Oral small-molecule GLP-1 drugs penetrate deep into the brain to suppress cravings. 🧠 Read the full story ➡️ nih.gov/news-events/ne…

@So_Steculorum @LCReimon Amazing story! Congrats!!

🤩I’m beyond excited to finally share our paper! 🎉 It’s been a long journey and a true team effort. Congratulations to our outstanding first authors, @LCReimon and Ayden Gouveia, and to all of the co-authors who made this possible 🙌! nature.com/articles/s4225…

(1/n) Why is it so hard to stop eating when something tastes amazing? Our new @ScienceMagazine paper reveals that dopamine helps sustain our drive for tasty treats—and may explain how anti-obesity Ozempic tames those urges doi.org/10.1126/scienc…

@ErezUzuner 🖤🖤

@bugragungul Congrats Buğra 👏 Well deserved 🥂

Excited to share two big highlights from my research journey! My abstract “A Brain Reward Circuit Inhibited by Next-Generation Weight Loss Drugs” was chosen for an SfN press conference — <50 selected out of 10,000+! We’ll be sharing our work to the media this November.

Grateful to share our work with the scientific community & the public — and to our amazing team: Elizabeth Godschall, Isabelle Sajonia, my PI @AliDGuler & collaborators @deppmann @AUGCsoup

Also, next week I’ll present at GRC on catecholamines: molecular, circuit, behavior & brain disorders — joining top scientists to discuss neuromodulatory systems.

@yulonglilab Amazing tool!! Can’t wait to start using them

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine science.org/doi/10.1126/sc…

A dedicated neural circuit through which small molecule GLP1RAs modulate reward processing, suggesting broad therapeutic potential in conditions of dysregulated dopamine signaling including substance use disorder and binge eating pubmed.ncbi.nlm.nih.gov/39763823/

You can read more about it here: biorxiv.org/content/10.110… Send us feedback on how we can improve our manuscript. All this work was led by three very talented graduate students: Lizzie Godschall @LizzieGodschall, Buğra Güngül @bugragungul and Isabelle Sajonia @isabellesajonia. 15/

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/

🇹🇷👏 Commiserations to Türkiye on their #EURO2024 exit... A team with immense passion that produced several high tempo, entertaining matches! With Arda Güler, Yıldız, Yılmaz, Kadıoğlu etc, they will definitely be back... 🌟🌟

TEŞEKKÜRLER BİZİM ÇOCUKLAR 🇹🇷 A Milli Futbol Takımımız, Hollanda’ya 2-1 mağlup olarak EURO 2024’e çeyrek finalde veda etti. Yaşattığınız her şey için teşekkür ederiz. Sizinle gurur duyuyoruz. 🇹🇷🐺

Getting addicted to these Lelechas. Thanks to my friends from 🇨🇳

Go 🇹🇷!

Neurons in the central amygdala just threw the ultimate glow-up party! They brighthened my day 🎉🧠 Image credit: @LizzieGodschall

Nocturnal researchers 🙃