Allen Green, MD

@Degen_Drama Many people feel very good. They report great sleep, more energy, clearer thinking. Others feel the same afterwards but notice improvements as time goes by

Do you feel insanely good after this or what

@doctorcalf TPE does about 4x the volume in one setting which requires the use of a replacement fluid. This is pretty much always albumin in the outpatient setting. Albumin is one of the strongest antioxidants and anti-inflammatories we have in our body

What’s different from doing this and donating blood plasma a few times? I imagine it’s how volume and they do a better job rehydrating but was curious about difference beyond that.

There’s not a ton of work out there regarding detoxification. Forever chemicals (PFAS) are certainly removed. A plasma donation study showed ~30% over a series of donations. TPE removed significantly more volume so likely removes significantly more each time. Microplastics showed upwards of 60% removal in folks with the highest levels (Weinstein, et al 2026). Very little on molds, bacteria, etc and honestly if folks have those running through the blood, they need medication urgently. An argument for lowering total body burden is that as we pull from the plasma the substances may diffuse from tissue sources, but there have been no studies on this.

This is obviously a marketing pitch, but since I like to look at validity of claims, I decided to see if these were true. > The plasmapheresis (TPE) essentially pulls out 20% of all of your toxins in about 3 hours. The 20% of all toxins is unfounded in the literature; at least I couldn't find anything. There are studies that claim high clearance but that's only of circulating plasma, not whole body load, so it's much smaller than that. What are the toxins Dr. Morse is talking about? > Think microplastics, heavy metals, viruses, bacteria, mold, fungi, inflammation, spike proteins, pesticides and so much more are removed! These are a large range of weighted materials in the blood. Best evidence that these are removed in any meaningful way is uneven across this list. - Microplastics do circulate in blood (Leslie, et al. 2022), lodge in arterial plaques (Marfella et al., 2024), but the best studies show that TPE assays only really see particles >= 1um - Heavy metals like lead and mecury are overwhelmingly stored in bone and intracellularly. This has been shown in PCB apheresis pilots (Esser et al, 2017) - Viruses, bacteria, mold, fungi -- no controlled evidence with TPE that I could find on this. Show me the data, doc! I also looked at the Substack article posted -- most evidence cited is from TPE used in acute, single-drug overdose situations. These are high protein-bound scenarios!

@DRitterMD While I can’t vouch for everything he does, TPE is probably the thing with the most scientific backing.

When “physicians” like this take the Hippocratic Oath are they lying through their teeth or do they lose their moral compass later?

@And_Man_Ent Yes, but with real science behind it this time.

Is this just new age bloodletting ?

@mcatanne When done by people who know what they’re doing. (Most people doing it dont)

? Is this safe?

@JasperMSMKT Liver and kidney never needed to remove forever chemicals or microplastics. They also don’t touch autoantibodies, cytokines, inflammatory compounds, etc. There are 100+ indications for TPE.

If your body can’t filter toxins, you don’t need plasmapheresis. You need a new liver and/or kidney transplant. This is quackery.

There’s a growing body of research into its use beyond what it has traditionally been used for. Alzheimer’s disease being the most exciting. Detoxification is an interesting goal, but we don’t have evidence yet showing improved healthspan from doing so. It should also be noted that we don’t know the extent that TPE can lower full body stores as many toxins are stored in fat and tissue.

If you are considering doing this, just take the $8000 and light it on fire. At least you’ll get some temporary warmth.

The clots are from contact activation and not using sufficient anticoagulant. The way the dialysis filter is set up for EBOO, it can’t possibly dialyze or filter anything. For starters, there’s no dialysate. Dialysis pulls off compounds with constant diffusion into the dialysate. The blood is passing outside the lumen of the filter and does not go through any of the tiny pores. Nothing is filtered. The only thing it can possibly do is pump gas into the blood. allenpgreenmd.com/blog/is-eboo-b…

@AllenPGreenMD @LuckyPhelps Lol. You think a dialysis filter doesn’t filter anything out? How do you explain the clots that I pull out?

I do this treatment at my office in Miami (The Osteopathic Center). The plasmapheresis (TPE) essentially pulls out 20% of all of your toxins in about 3 hours. Think microplastics, heavy metals, viruses, bacteria, mold, fungi, inflammation, spike proteins, pesticides and so much more are removed! The bag of toxins should be clear and apple-juice colored. Usually it’s closer to orange juice. See the photo below of one my partner did. It costs $8,500 (if you’re doing one round), and the price drops with more rounds. Some places, including us, will do an IV dose of Stem cells after to help with healing, inflammation, and anti-aging. Removing all the toxins and inflammation with the plasmapheresis allows the stem cells to find their targets better. More info about TPE here: @drjessemorse/note/p-192529975?r=ntnvf&utm_medium=ios&utm_source=notes-share-action" target="_blank" rel="nofollow noopener">substack.com/@drjessemorse/…

@LuckyPhelps @DrJesseMorse EBOO doesn’t filter anything at all.

@DrJesseMorse Interesting but unaffordable for 99% of us 😞

@Jeff_T @DrJesseMorse It removes the toxins, whether or not toxin removal improves healthspan remains an active question. There is some evidence that stem cells do better (in a Petri dish) when cultured in plasma post TPE. But these were small trials.

Yes, therapeutic plasma exchange has been around since the 1970s. No argument there. My question isn't whether TPE exists. It's whether there's high-quality evidence that an $8,500 "detox" in otherwise healthy people improves healthspan, removes "toxins" in a clinically meaningful way, or makes stem cells work better. Those are very different claims. Show me the randomized clinical trials supporting those claims.

@DreAllDay Your whole argument was about losing weight via discipline. And you added that doctors can’t be trusted because they prescribe. I directly discussed both. Mind reading not required.

You're defending a different argument than the one that was made. Nobody disputed that GLP-1s can save lives or that some patients need medication. The claim I challenged was: "People against GLP-1s are just frustrated." That's mind-reading—not evidence. Your colleague psychoanalyzed critics. You’re discussing legitimate medical indications. Those are two different conversations.

I’d never considered this concept. So. Using drugs to lose weight ≠ losing weight via discipline and effort. The discipline & effort are usable in other aspects of life. The drug user is tethered to the drug. Outcome without effort appears to be a free result. That’s impossible. Goes against the laws of the universe. And: You’re a doctor. Respectfully — you would appear to have a vested interest in patients using drugs over going to the gym. You’re needed for prescriptions, their use, etc. You’re irrelevant when people choose the gym.

@CoffeeBlackMD Lmao! This one struck a nerve!

F. A. C. T. S. If you can’t “deal” with time, you are either disabled mentally (special needs) or an asshole. There is no in between. If special needs we will get you into all the programs go need good buddy! If an asshole, you can f*ck right off with your “blindness” and good luck. No one will do business with you. Or be your friend. Die alone and broke. Idc. Enjoy the “blindness.”

It’s okay for people to disagree with you about your favorite diet. It shouldn’t hurt your identity. If it does, maybe you’re in a cult.

@ok6ixx Let him know he’s started a movement. Stay Dangerous!

@meagankae @BillFeuer @nicknorwitz @foundmyfitness You think saying a diet is losing steam is an attack on a segment of the population?! It’s a diet.

@BillFeuer @nicknorwitz @foundmyfitness It might have been her intent, but the post came across as an attack on the one segment of the population that is probably the most healthy.

Respectfully, @foundmyfitness, I think you are missing the bigger picture and key nuances on the carnivore diet and providing a reductionistic point of view. Here’s my respectful pushback: As with any extreme dietary intervention, people adopt carnivore for very different reasons. Some are experimenting, trying to lose weight, or simply exploring what works for them. That is probably the larger group. But others are using it for severe, treatment-resistant conditions: autoimmune and inflammatory diseases, mental health conditions, neurological disorders, and so on. To me, it feels like a misattribution to conclude that because some otherwise healthy people eventually move on from carnivore as part of an iterative self-experimentation process, the intervention itself lacks serious therapeutic potential. And, in some cases, that intervention may have been what enabled them to move to the next phase. Now, to be clear, I say this as someone who has experimented with many dietary approaches (including carnivore, although I am not now a full carnivore) and continues to do so, because life itself is one big experiment. But none of that means the intervention doesn’t have serious legs. Take treatment-resistant inflammatory bowel disease as an example. Fiber-free diets are already used to for treatment-resistant Crohn’s and colitis, often with meaningful clinical benefit (60-85% of cases), in part through shifts in microbial fermentation and gut irritation. It’s a tool that is used clinically. It’s not even fringe. (Interesting mechanisms paper in Cell Host & Microbe: Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont PMID: 37967555) Combine that with the anti-inflammatory effects of ketones and data ketone signaling and intestinal stem cell renewal (more mechanistic discussion in this case series: PMID: 39296504), and you have a biologically plausible, clinically-grounded argument for why a carnivore-style diet could be especially effective for certain patients with IBD. One could make similar arguments for a range of other conditions. Then the question becomes: is a zero-plant diet “optimal” long-term? The answer is obviously contextual. For longevity alone, in the average healthy person, probably not. Who ever made that argument? But for someone using the intervention effectively to manage a debilitating condition, I don’t think it’s for you or me to impose a value judgment on whether it is “optimal” long-term. People are optimizing for different things. So, tell me, did I say anything that was unreasonable?

@3xpops @foundmyfitness Sorry to hear it

@foundmyfitness Yeah, I fell for this and basically just spiked my soft plaque. Lesson learned, not only about food but also about listening to idiot podcasters.

I'm not surprised that the popularity of the carnivore diet is losing steam. It never was a durable solution for most people. Ultimately, part of what people were experiencing were the benefits of an elimination diet. But that doesn’t mean a zero-plant diet is optimal long term. We’re already seeing that play out. Many of the loudest carnivore advocates are starting to add back fruit, vegetables, and other whole foods.

@paulctan @MarkBski When was your heart attack?

@MarkBski Carnivore for 3 years now.

One of the main reasons people fail or fall off carnivore or keto diets is sabotage, like Dr. Patrick displays here. About 45 seconds after taking me off my blood pressure meds, I told my doctor I lost 50+ pounds with a keto diet. He looked me square in the eye and said "Don't eat like that." People like Dr. Patrick and my doctor should know and act better, but they don't. I'm 7 years successful, lost 100+ pounds of fat, and at 64 stronger and healthier than most men my age.

@racisttechbro @nash_vandy1994 @IamSean90 Perhaps. It’s just that this chart isn’t evidence of that.

@AllenPGreenMD @nash_vandy1994 @IamSean90 It’s undeniable that Bukele’s mass incarceration strategy defeated the gangs and dramatically decreased the crime rates

Bukele was elected the Mayor of San Salvador in 2015 which is El Salvador's most populated city with 1/4 of the nation's population. His approach on crime & the resulting reductions there, is what led him down the path of becoming president. Your ignorance is unparalleled