Alissa Michel

2025 was a banner year for BC therapy across all subtypes. My take on the top practice changing trials: 1. DESTINY-Breast09 | ASCO 2025 1L HER2+ MBC: TDxD + P vs THP. Median PFS 40.7 vs 26.9 months; HR 0.56. Regimen FDA-approved. 2. lidERA | SABCS 2025 Adjuvant ER+ BC: Giredestrant vs standard ET. Improved iDFS, HR 0.70. 3. monarchE (OS update) | ESMO 2025 High-risk ER+ BC: Abema + ET vs ET improved OS; HR 0.84. 4. DESTINY-Breast05 | ESMO 2025 High-risk HER2+ BC with residual disease: TDxD vs T-DM1 improved iDFS. 5. NeoCARHP | ASCO 2025 Neoadjuvant HER2+ BC: Carbo-containing vs carbo-free chemo demonstrated noninferior pCR. 6. HER2CLIMB-05 | SABCS 2025 1L HER2+ MBC: Tucatinib + HP maintenance vs HP alone improved PFS 7. TROPION-Breast02 | ESMO 2025 1L PD-L1- mTNBC: Dato-DXd vs chemo improved OS (23.7 vs 18.7 mo, HR 0.79). 8. ASCENT-04 | ASCO 2025 1L PD-L1+ mTNBC: Saci + pembro vs chemo + pembro improved PFS. 9. ASCENT-03 | ESMO 2025 1L PD-L1- mTNBC: Saci vs chemo improved PFS. 10. VIKTORIA-1 | ESMO 2025 2L ER+ MBC, PIK3CA WT: Geda + palbo + fulv triplet and geda + fulv doublet vs fulv improved PFS. 11. SERENA-6 | ASCO 2025 1L ER+ MBC switch: ctDNA-detected ESR1 mut; switch to camizestrant + CDK4/6i improved PFS vs AI + CDK4/6i. 12. DESTINY-Breast11 | ESMO 2025 Neoadjuvant HER2+ BC: TDxD + THP vs ddAC/THP improved pCR. @theNCI @SusanGKomen @METAvivor @BreastCancerOrg @LivingBeyondBC @BCRF @PIK3CApathbreak @NBCCStopBC @Perlmutter_CC #bcsm

Thank you so much for this honor @ConquerCancerFd ! #asco2024 #endcancer @DrDawnHershman @MAccordino @MichaelMayMD @MSHughes_MD @KristineLacuna @columbiacancer

So thrill to see our ⁦@columbiacancer⁩ ⁦@ColumbiaMed⁩ acknowledged ⁦@ASCO⁩ ⁦@ConquerCancerFd⁩ grants award ceremony 👏🙌🙏 congratulations to all 🎉

Our @columbiacancer @ColumbiaMed #Breast_Team well represented @SABCSSanAntonio #SABCS23 - so thankful to work with this amazing crew 🙏❤️🙏

Concrete jungle where dreams are made of…… @usopen

@NoahKahan NYC again!!! How about Beacon Theater?

Another tour ?

A beautiful view to start the week at @ColumbiaMed/@nyphospital. 😍 📷: @drmnstein

Daily reminder that Ticketmaster is a monopoly, it’s merger with LiveNation should never have been approved, and they need to be reigned in. Break them up.

If airlines can ask us not to eat peanuts on board if there is someone with a peanut allergy, why won’t they ask us to wear a mask if there’s an unvaccinated 4 year old or cancer patient on board?

The dmv be like you forgot to bring the Declaration of Independence

not New York City sending me an emergency alert telling me to turn off my ac when Times Square is lit up like she is

115,000 healthcare workers have died of Covid. As the pandemic rages across the globe, the overwhelming majority of my healthcare colleagues around the world haven’t yet had access to a vaccine, while wealthy countries like the US are sitting on a massive pile of surplus doses.

Gianna Floyd still goes to bed tonight without her father. None of this will undo that reality.

@MandyPx123 Even multigrain 😋

"Finding light in the darkness is a very American thing to do. In fact, it may be the most American thing we do." @POTUS

Sorry I’ve been quiet my current schedule is wake up, go to work. keep people alive for 13 hours, go home, research expensive candles and fantasize about what they smell like, sleep, repeat

You can’t honor our frontline workers, while also fill a stadium with 25,000 people.