Amplify Partners

Databases typically take a decade to build. @TigerBeetleDB went from zero to Jepsen-passing in 3.5 years by doing everything differently: zero dependencies, writing code slow, and building entirely on Deterministic Simulation Testing. How they did it: amplifypartners.com/blog-posts/why…

Cancer drug discovery’s brutal reality: only 1 in 10,000 promising molecules actually helps patients. Most AI biotech focuses on generating more candidates faster. Instead, @tahoeai is building digital cell models to predict which drugs will actually work: amplifypartners.com/blog-posts/can…

“Once you’ve found all the bugs in something, programming feels completely different. It’s like being half of a cyborg, or having a jetpack.” The technology behind FoundationDB’s impossible speed: amplifypartners.com/blog-posts/a-d…

Over 1 billion sandboxes have been launched on Modal. Since launching three years ago, we've seen Modal Sandboxes become foundational to how AI is being built. Today, teams like @Lovable, @tryramp, @cognition and more are using Modal Sandboxes to power everything from coding platforms and background agents to RL infrastructure at scale.

Incredibly in depth guide to designing an antibody with (OSS) Boltz:

Technical founders hiring their first marketer tend to underestimate how much they don’t know — not just about marketing, but about what kind of marketer they actually need. A practical guide for founders: amplifypartners.com/blog-posts/how…

If we want to accelerate progress, we don’t need more ideas or more code. We need to run better experiments faster. @sarahcat21 explores why this requires collaboration among researchers, statisticians, and engineers: amplifypartners.com/blog-posts/the…

Introducing Uni-1, Luma’s first unified understanding and generation model, our next step on the path towards unified general intelligence. lumalabs.ai/uni-1

After helping dozens of technical founders land their first customers over 20+ years, @marklarosa compiled everything into one guide: how to run pilots that actually convert. From finding design partners to closing deals, this is the playbook for your first few customers → amplifypartners.com/blog-posts/the…

What separates great founding engineers from good ones? We asked founding engineers from @langchain, @perplexity_ai, and @stytchauth. One thing: Knowing which decisions can be undone later. Watch the panel: youtube.com/watch?v=qTnxPy…

New Runway Meetups are happening across the globe. Learn more, RSVP or host your own at the link below.

AlphaGo won partially through the innovation of self-play…and yet don’t we do this with LLMs. Instead of scaling compute, we should be teaching models to design their own curriculum: amplifypartners.com/blog-posts/sel…

70-90% of cancer deaths share the same trajectory: They aren't the result of the primary tumor, but the recurrence and spread of disease after initial treatment. It's a massive problem. Precision cancer vaccines might be able to change this. For decades, researchers have worked with a shared vision of stimulating the immune system to recognize cancer and prevent its return. The results have been mixed. It's an extraordinary challenge that requires a synthesis of computer science, biology, and clinical design. Infinitopes has obsessed over solving this problem. They've built a platform focused on combining the Right Targets and Right Vectors to treat the Right Patients at the Right Time. At the end of last year, we co-led their latest $15.4M financing with Octopus Ventures. Now they have entered the clinic. It’s a true privilege to partner with the Infinitopes team at such a pivotal moment. I wrote for @AmplifyPartners about Infinitopes and their Ph1/2a VISTA trial that is underway: amplifypartners.com/blog-posts/inf…

Best to describe Moment as the most incredible engineering you've seen in a while, in a package so simple it feels like Notion.

So basically @AmplifyPartners with agents sprinkled in. @dbeyer123 you have your marching orders.

Building agents that don’t “give up” on complex tasks requires better (real?) context engineering. @Hightouch’s team breaks down their agent harness — dynamic planning loops, file buffering, subagents that explore and report back summaries: amplifypartners.com/blog-posts/how…

The founding PM has an incredibly opaque and difficult job, yet simultaneously one of the most important roles that early-stage companies will hire. @Grace_Ge talks to two seasoned founding PMs: amplifypartners.com/blog-posts/git…

Vortex is BOTH 38% smaller and has 10–25x faster scans than Parquet+ZStd for TPC-H SF10 We implemented BtrBlocks-style cascading compression in Vortex that recursively tries codecs like ALP, FSST, and bit-packing, letting the data pick the best encoding spiraldb.com/post/cascading…

Today, we're announcing Sourcegraph 7.0, a release that marks the beginning of a new chapter for our company and product. Over the past several releases, we've shifted our focus. We're doubling down on being the intelligence layer that developers and AI agents rely on to navigate, understand, and operate on large codebases. sourcegraph.com/blog/a-new-era…