Ariax Bio

BindCraft is generating high-affinity peptides from structure alone 🧬 MDM2: 47% hit rate (7/15 tested) with nM affinity. For WDR5, structural predictions were so precise they enabled "one-shot" stapling for a 6× potency boost (Kd 39nM). No phage display. No alanine scanning. GenAI is accelerating rational chemical design with less wet-lab screening.

1/2 🧵 We're learning how to use BindCraft at the Center for Genomic Sciences in Mexico 🇲🇽 BindCraft achieves an experimental success rate of 10–100%, compared to the 0.2% for traditional approaches 🔥 When people talk about drug design, they're actually referring to this.

Preparing PDB files for protein design usually means wrestling with PyMOL or ChimeraX. We're making it easier. Watch us use our new Prep Inputs feature to go from PDB fetch → structure trimming → hotspot selection → launching a design job in a leisurely 75 seconds.

I love these and also...they're ludicrous. (BindCraft designed miniprotein for crystallizable core of NUTM1)

The ability to design antibodies against any protein of interest has major implications for medicine, biotech, and basic science. Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving  4–22% success rates with efficient experimental validation.