Ang Cui, Ph.D.

✨#ImmuneDictionary✨is out today in @Nature! Paper nature.com/articles/s4158… Software immune-dictionary.org We created scRNA-seq dictionary of 17+ immune cell types responding to 86 cytokines in vivo, discovered the immune system is far more complex than previously known 1/

My lab was very happy to present our latest work at #AAI2025 @ImmunologyAAI in Honolulu, Hawaii! Exciting scientific exchanges with colleagues truly dedicated to driving immunology & immunotherapy research forward.

Happy to share our publication on a single-cell atlas of human liver immune (myeloid) cells in #HCVCure in the @JHepatology ! A tribute to one of the most remarkable medical breakthroughs of modern times: the #HCVCure. Since the introduction of direct-acting antivirals in 2011, hepatitis C virus (#HCV) infection has become the first chronic viral infection to be curable, with newer generation antivirals achieving a >95% success rate within just 8-12 weeks of treatment. What lessons can we learn from this success? Paper: journal-of-hepatology.eu/article/S0168-… Editorial: journal-of-hepatology.eu/article/S0168-… As part of a Phase 3b open-label clinical trial, we used single-cell genomics to systematically profile myeloid cells in the livers of individuals with HCV before and after viral clearance. We identified cell populations with immunoregulatory potential during active infections: ISG-high neutrophils and eosinophils were found to upregulate PD-L1 and IDO1, respectively, and proliferating dendritic cells increased post-cure. Further, we identified a correlation between pre-treatment viral load and the post-cure host immune state. We hope the data will inspire the development of immunotherapeutic strategies for other infections that currently lack a cure. Acknowledging our incredible team for making this work possible @nalatrak, #BoLi, @raychungmd, #NirHacohen, #MichaelWallace, #AnnaGonye, #ChrisOetheimer, #HaileyPatel, @PierreTonnerre, #GeorgLauer, and many others. @broadinstitute @MGHMedicine @harvardmed #HCV #Liver #Infections #ImmuneCells #SingleCell #DirectActingAntivirals #DAAs

I’m excited to share our latest study led by @GiuliaPasquesi out today in @CellPressNews , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55

Congratulations to 2023 ICIS YI Award winner recognized as one of the 35 innovators under 35 worldwide by MIT Technology Review!!!

@CytokineSociety Thank you @CytokineSociety !

Congratulations Professor Hinton for winning the 2024 Nobel Prize in Physics! Big day for #AI #ML

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

I am happy to share a large part of my postdoctoral work published in @SciImmunology! Using LIPSTIC, we identify and characterize antigen-presenting dendritic cells (DCs) in the tumor-draining lymph node and tumor microenvironment science.org/doi/10.1126/sc…

DCs that present antigen to tumor-specific CD4+ T cells in the tumor and tumor-draining lymph node @SciImmunology @victora_lab science.org/doi/10.1126/sc…

#SameSameButDifferent! Chudnovskiy @victora_lab &co use #LIPSTIC @SciImmunology to show that only a fraction of DCs interact & activate T cells in the tumor draining lymph node & tumor microenvironment & found IL-27 potentiate anti-tumor T cell responses! Doi.org/10.1126/sciimm…

Check out our updated #bioRxiv preprint on #bionformatics #Rstats method CRAWDAD (Cell-type Relationship Analysis Workflow Done Across Distances) for quantifying cell-type spatial relationships in #spatialomics data 📰: biorxiv.org/content/10.110… 💻: github.com/JEFworks-Lab/C…

@lindaunobel Thank you! @lindaunobel

Congratulations to our Lindau Alumna 2023!😃Ang Cui also participated in one of our #LINO23 Panel Discussions mediatheque.lindau-nobel.org/recordings/410…

@QuinaScience Sounds like a plan!

@QuinaScience Congratulations on this exciting milestone!!

@jimmykoppel Thank you!!

Much deserved, Ang!

I am thrilled to have been selected by MIT Technology Review @techreview as one of the 35 Innovators Under 35 worldwide! #ImmuneDictionary #CytokinesPower #TR35 #biotech technologyreview.com/innovator/ang-…

THANK YOU to the ImmPort Big Data in Immunology speakers @NimaAghaeepour, @Reuben6Sarwal, @AngCuiPhD, Dr. Mattew Altman, & organizer @Sanchitab for sharing your research, resources, & AI-ready data sets! Find ImmPort’s free data & resources here bit.ly/3KRhhrW #FOCiS2024

Introducing: an immune dictionary! 📘 @AngCuiPhD and a team at the @BroadInstitute created a #scRNAseq dictionary of 17+ immune cell types responding to 86 cytokines in vivo. 📎 @Nature paper: go.nature.com/47GmOuC 🎙️ Episode: apple.co/48TSJIY