@jitcancer 📄 Read the paper here: jitc.bmj.com/content/14/1/e…
#CancerImmunotherapy #CARTcells #PancreaticCancer #InnateImmunity
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Anne Marie Senz
282 posts
Anne Marie Senz
@AnneMarieSenz
Scientist #Immunotherapy #CARTcells #CellandGeneTherapy
Mainz, Germany Katılım Mart 2012
255 Takip Edilen142 Takipçiler
🎉 Excited to share the data from my PhD thesis is now out in @JITCancer!
Our work explores how RIG-I agonists can boost CAR-T cell therapy in pancreatic cancer.
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@jitcancer 🙏 Huge thanks to my co-first author Bruno L. Cadilha, my PhD supervisor @LM_Koenig , all co-authors, and the Cancer Vaccine Lab at @KlinPharm
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@jitcancer 🚀 Why it matters:
These findings support the clinical translation of RIG-I agonist priming as a co-therapy with CAR-T cells, with the potential to extend CAR-T efficacy beyond hematological malignancies to solid tumors.
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@jitcancer 🧠 Importantly, RIG-I priming also induces antigen spreading and a CAR-independent endogenous T-cell response, supporting long-term tumor control.
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@jitcancer 🔬 We show that local priming with a RIG-I agonist (3p-RNA) enables durable CAR-T responses in PDAC by improving CAR-T infiltration, survival, and function.
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@jitcancer Pancreatic ductal adenocarcinoma (PDAC) is highly immune-excluded, making it a major challenge for CAR-T cell therapy in solid tumors.
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Anne Marie Senz retweetledi
New Dr. in town🎓💥Huge congrats to @AnneMarieSenz on a fantastic dissertation defence #KönigSchnurrlab @LM_Koenig
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Registration is open for @inpharma2022, secure your spot to learn more about the different career paths after a PhD and Network with hiring companies!
#careerdevelopment #CareerOpportunities #careeradvice @LMU_Muenchen @LMU_Uniklinikum @LMU_Immutherapy @iTarget_ENB @MPI_Biochem
Munich, Germany 🇩🇪 English
Honored and immensely thankful for the opportunity to do research in an outstanding lab with an amazing team. Big thank you to the organizers of @C_IMT for a great and enriching conference! #CIMT2022
Lars M. Koenig@LM_Koenig
Very proud of our PhD candidate @AnneMarieSenz for a terrific talk at #CIMT2022 about enhancing CAR T cell therapy in solid tumors by RIG-I-based preconditioning of the TME
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Anne Marie Senz retweetledi
We are excited to announce this year’s InPharma conference taking place live at MPI Munich!
- workshops
- talks from industry
- meet & greet with company leaders
& a lot more!
Registration opens soon, stay tuned!
Also check out our website:
sites.biochem.mpg.de/inpharma-2022
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Anne Marie Senz retweetledi
New #JITC article: OrienX010, an oncolytic virus, in patients with unresectable stage IIIC–IV melanoma: a phase Ib study bit.ly/3uVp67Q @RobertAndtbacka
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Anne Marie Senz retweetledi
New Research: Apoptosis, Pyroptosis, and Ferroptosis Conspiringly Induce Immunosuppressive Hepatocellular Carcinoma Microenvironment and γδ T-Cell Imbalance: Hepatocellular carcinoma (HCC) is highly malignant and prone to metastasize due to… frontiersin.org/articles/10.33… #immunology
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Anne Marie Senz retweetledi
Exceptional & innovative work by guru immunologist Aubrey Smith @Aubrey_Smith04 from @PaulosLab in advancing adoptive CD8 T cell therapy with B cells! Hot off press @jitcancer! @sitcancer @C_IMT @celltherapynews
Journal for ImmunoTherapy of Cancer@jitcancer
New #JITC article: B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity bit.ly/332sJis @Aubrey_Smith04 @PaulosLab
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Anne Marie Senz retweetledi
A must read paper: The hallmarks of cancer updated concept because #cancer is really complex! @CD_AACR
cancerdiscovery.aacrjournals.org/content/12/1/31
@OncoAlert @AACR @DanaFarber_GU
cancerdiscovery.aacrjournals.org/content/12/1/31
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"It’s not possible to end a global pandemic one country at a time.
Countries around the world must work together to share equal access to COVID-19 vaccines, tests and treatments.
This isn’t over for any of us until it’s over for all of us."-Unicef
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Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors frontiersin.org/article/10.338…
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