Lars M. Koenig

Interferons in health and disease. Check out this review by @Lo_Zanzi & Daniel Boehmer in @CellCellPress #AAI2026 hubs.li/Q04c5DJg0

New #JITC article: RIG-I agonists promote antigen-spreading and facilitate durable CAR-T responses in pancreatic ductal adenocarcinoma jitc.bmj.com/content/14/1/e… @LM_Koenig

@jitcancer 🙏 Huge thanks to my co-first author Bruno L. Cadilha, my PhD supervisor @LM_Koenig , all co-authors, and the Cancer Vaccine Lab at @KlinPharm

#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 authors.elsevier.com/a/1leKGL7PXuFTj

Immensely honored and excited to share our new review on all things Interferons out now in @CellCellPress. Grateful to the brilliant & inspiring @Lo_Zanzi for the chance to contribute! Check it out: authors.elsevier.com/c/1leKGL7PXuFTj #InterferonPower @harvardmed @BostonChildrens

I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @OliveiraMann biorxiv.org/content/10.110…

Happy to share the first preprint from my lab by @BekereIndra and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity! Check out Indra’s thread for a summary:

Now online! Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair dlvr.it/TG1dnk

We are thrilled that our study on PGE2-mediated impairment of TCF1+ stem-like CD8+ T cell responses in cancer, with (twitterless) Sebastian Lacher as first author, is now published @Nature! 👇 a short 🧵 below! nature.com/articles/s4158…

Online now: Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production dlvr.it/T3NKWc

Thank you to @CRC_TRR332, @dfg_public consortium on #neutrophils, for organizing this event. @soehnleinlab @SperandioLab @AGonzalezLab1 @DrDMaierBegandt

Very excited that our paper on iPSC-derived bone marrow organoids is now out @NatureMethods twtr.to/0eBZd Thanks to the KleinLab @LMU_Muenchen @LMU_Uniklinikum and great collaborators @MarrCarsten @HelmholtzMunich @penningerlab @IMBA_Vienna @kotlarz_lab @EnardHellmannWG

Come join us in Rotterdam for Toll2024. A fantastic lineup of speakers. Early bird registration February 23rd. toll2024.org/register-now/

Humbled by the intellectual rigor and diversity at #NeurIPS2023. Engaging with an array of brilliant minds has broadened my understanding of AI and inspired insights into its impactful applications in biology. Being part of this vibrant community is truly an enriching experience.

Thrilled to introduce our latest research at the upcoming #NeurIPS DGM4H workshop this December: “flowVI: Flow Cytometry Variational Inference” 🥳👨‍💻🧬. Many thanks to @fabian_theis @LM_Koenig @adilmeric12 @HelmholtzMunich. Dive into our full paper 📰: doi.org/10.1101/2023.1…

New Dr. in town🎓💥Huge congrats to @AnneMarieSenz on a fantastic dissertation defence #KönigSchnurrlab @LM_Koenig

S100A8/A9 release from #neutrophils involves a Nlrp3/gasdermin D axis. Check latest paper from @SperandioLab in @NatImmunol. Congratulations! @CRC_TRR332 @LMU_Muenchen @uni_muenster nature.com/articles/s4159…

Targeting innate immune pathways for cancer #immunotherapy: Innate immune pathways are commonly discussed targets of cancer immunotherapy. Cao & Kagan review the state of this rapidly advancing field of study. They introduce the concept that five key innate immune activities in DCs are needed to stimulate durable T cell-mediated anti-tumor immunity. authors.elsevier.com/a/1hl3a_OR%7Ey…

Living the #campari and #cancerimmunology life🍹Excited to have @LM_Koenig #KönigSchnurrlab and four of our post-docs at #CICON23 Milan, Italy. @MarcelTrefny

Great conceptual insights into innate immunity by @jkagan1 🤩 … and be aware of the three fallacies of innate immunology. 👇