Dr. Brad Reinfeld, MD PhD

🎉 CRI is thrilled to announce our inaugural class of IGNITE fellows! These nine extraordinary young researchers span nine different institutions, with projects focused on seven distinct cancer types. Discover: bit.ly/44vR8ZO #Immunotherapy #FundCancerResearch

@QuinlanSievers This metabolism thing is gonna catch on. I promise @MaximMaron

Wow wow nature.com/articles/s4158…

Congratulations to @KotechaMD and colleagues on this important @JCO_ASCO publication evaluating allogeneic CD70-directed CAR T-cell therapy in advanced RCC. 🚨 ascopubs.org/doi/10.1200/JC…

Clonal lineage tracing of innate immune cells in human cancer dlvr.it/TTXYR2

Online Now: GABA promotes resistance to immunotherapy in patients with TLS-positive tumors dlvr.it/TTRKk3

Now online: CAR T Cells Targeting O-Glycosylated Fibronectin Exhibit Potent Cytolytic Activity and Combine with Tumoral Toll-Like Receptor Agonism to Overcome Tumor Resistance doi.org/10.1158/2326-6…

@AndreaCercek 🤩announced at #ESMOGI2026 phase 2 AZUR-1 will be presented at @myESMO #ESMO2026 which was created to validate her original single center Dostarlimab data in #rectal #cancer. Looking forward to the results! #CancerResearch @GSK_US @OncoAlert

Glycolytic capacity instructs tumour vasculature and response to immunotherapy dlvr.it/TTHMrt

@Banana_Oncology @PersonalisInc Discussing the risks/benefits of these tests stresses patients out. I’m interested to see where this goes given the prognostic role. However remains a test that rarely changes management (few stage II CRCs). Ordering it today can cause more emotionally/financially toxic IMO.

I would put it on a slightly different way. I think there are plenty of data suggesting baseline MRD status and/or on-treatment MRD clearance are strongly prognostic to long term survivals But we lack strong evidence from randomized trials that support whether such "prognostic signal" can be translated into clinical benefits through early escalation or vice versa (de-escalation) And 100% agree we are far from prime time for these MRD tests

Good news to $BLLN BillionToOne's ctDNA test demonstrating a median of 62 days lead time than conventional CT scans for IO monitoring Even greater news is that $PSNL @PersonalisInc ultra-sensitive MRD test is way more sensitive, demonstrated a median of 161 days lead time than conventional CT scans for IO monitoring, and is also now Medicare covered investors.personalis.com/news-releases/…

I was proud to present our work this week at the @AACR lymphoma conference in Philadelphia on behalf of the teams in the @AbdelWahablab lab at MSK, @Nurix_Tx , and the @TaylorJ_MD lab at U of Miami. Stay tuned for the final story and publication!

@S_Corcoran @dgermain21 You mean VIPPOLAR?!

nature.com/articles/s4159… We didn't really talk about it in our paper, but BCL2 was a top 10 synergistic hit in (I think) every Pola CRISPR screen we did. Also more evidence that CD79B expression =/= Pola activity. Watch out for the free MMAE!

From pioneering molecular imaging to defining the genetic basis of kidney cancer, Drs. Peter Choyke and Marston Linehan have changed how we diagnose and treat cancer over decades at @theNCI. Congratulations on this recognition and thank you. go.nih.gov/x8l3rbz

Toward understanding the rapid immune system dynamics in preterm infants: doi.org/10.1172/jci.in… Benjamin A. Fensterheim @benfens E. John Wherry @EJohnWherry & team @ChildrensPhila performed longitudinal high-dimensional immune profiling of residual whole blood from 38 preterm infants, finding lung disease and infections drive distinct changes to the immune system that reveal new potential targets for therapy. The figure: Immune cells and proteins change over gestation

My mom passed away from lung cancer one month ago. Balancing being a caregiver, family member and oncologist was the hardest thing I’ve ever done. I wanted to share some reflections on the experience. Thank you ASCO for giving me a platform to do so. connection.asco.org/do/painful-cla…

New review in @CircRes! GLP-1R agonists are more than weight loss drugs — we explore how they reshape lipoprotein metabolism & adipose tissue to reduce CV risk beyond adiposity. doi.org/10.1161/CIRCRE… #GLP1 #Cardiology #Lipids

After 15 years of training, excited to be starting as a Genitourinary Oncologist and Instructor @MSKCancerCenter! Very thankful to my wife & daughter who have put up with me during my training, the fellowship program, and all my incredible mentors along the way! @MSK_DeptOfMed

Results of the T-DXd/durva arm of #BEGONIA for 1L mTNBC are now out in @NatureCancer. High efficacy, with ORR 62% and mPFS 12.6 months. Strikingly, deep responses observed even in HER2-0 (null) dz, reminding that IHC is a poorly predictive ADC biomarker. nature.com/articles/s4301…

Lipid droplet is key in early antiviral defence!! Integrative proteomics and lipidomics reveals dual roles for lipid droplets in the host cell antiviral response. @nature nature.com/articles/s4146…

Online Now: Clonal lineage tracing of innate immune cells in human cancer dlvr.it/TStGjW