Barbara M Boyd
550 posts
Barbara M Boyd
@BarbaraMBoyd
I am the Treasurer of Promethean PAC. I am writing to win the 2026 elections for Trump. Find Oppo, Policy, State of the Race at https://t.co/yOycyBTAAg
Breaking! The FBI held a tabletop exercise months before January 6. And even discussed charging folks majorly even for misdemeanors. And this exercise is where the planning for the informants came into the picture.
I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters. Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery. Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado. Here's what they erased. Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls. Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease. Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there. So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath. Not patched. Reversed. Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored. Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible. The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away. But something considered permanent for forty years just came off human tissue. We spent a century learning to slow aging. Someone finally figured out how to erase it. Thank you @theallinpod @friedberg @chamath @pesottas
Honored to welcome Iraqi Prime Minister Al-Zaidi to Washington and witness the signing of over $60 billion in commercial agreements with U.S. energy companies. Deepening U.S.-Iraq energy cooperation advances a more secure, prosperous, and energy abundant future for the United States, Iraq, and the world.
Moonshot AI, the company behind Kimi, has four core founders. Their backgrounds are unusually strong: - Founder and CEO Yang Zhilin studied computer science at Tsinghua before earning his PhD from Carnegie Mellon. He was the first author of Transformer-XL and XLNet, and previously worked at FAIR and Google Brain. - Co-founder and CTO Zhang Yutao earned his PhD in computer science from Tsinghua. His earlier work covered knowledge graphs and AMiner, and he previously co-founded Recurrent AI with Yang. - Co-founder Wu Yuxin studied at Tsinghua and CMU before joining FAIR. He worked with Kaiming He on Group Normalization and also created Detectron2. - Co-founder Zhou Xinyu studied computer science at Tsinghua and later joined Megvii, where he worked on turning research algorithms into production systems and co-authored ShuffleNet. They all share one root: Tsinghua University. Tsinghua is widely regarded as one of China’s top universities. In the latest U.S. News Best Global Universities ranking, it reached No. 6 worldwide. Its influence on China’s AI industry extends well beyond Moonshot. Z.ai, the company behind the GLM models, also grew out of Tsinghua. Its co-founder and chief scientist, Tang Jie, was once Yang Zhilin’s teacher. There is also a more personal connection. Yang and Zhou formed a rock band together at Tsinghua. Moonshot AI’s Chinese name, 月之暗面, comes from Pink Floyd’s album The Dark Side of the Moon, one of Yang’s favorites. Kimi may look like a young AI company. Behind it is a much older network of classmates, teachers, research labs, and friendships.
This is concerning. For the first time, a Chinese model Kimi K3 has taken #1 on the Frontend Code Arena and is scoring at or near the frontier on other benchmarks. Meanwhile America is tying itself in knots: politicians and bureaucrats are banning new data centers, piling on state regulations, and pushing for new federal agencies to pre-approve frontier models. This is how you lose the AI race. The rest of the world won’t play by our rules if we bog ourselves down. Permissionless innovation is how America won the internet and became the technological envy of the world. We can do it again with AI -- while addressing risks in a targeted way -- or we’ll watch our lead evaporate.
Please say some prayers for my baby Astro … diagnosed with terminal cancer at only 3 years old … He’s such a good boy … sometimes I feel we don’t deserve these beautiful creatures God has given us.
Must read thread. 👇 “The net result was very little retaliation against our tariffs. In fact, the President negotiated trade deals that involve our trading partners lowering their trade barriers and comitting to invest in the U.S. - effectively NEGATIVE retaliation!”
FT: "The world economy is at risk from the “tit-for-tat” economic warfare breaking out between nations, the IMF’s outgoing chief economist has warned." What many in the IMF have trouble understanding, and what Joan Robinson explained in 1937, is that trade conflict doesn't begin when some economies begin to retaliate after their increasingly onerous trade deficits lead to domestic political problems, but rather when mercantilist economies begin to implement wage-suppressing policies that lead to persistent, beggar-thy-neighbor trade surpluses. The IMF was created in 1944 to help manage unsustainable capital imbalances. By noticing the associated trade imbalances only after the consequences had led to deficit-economy retaliation, the IMF has been pretty much asleep at the wheel. ft.com/content/8199cd…
"The UAW is gonna fight like hell for Abdul El-Sayed," the union's president Shawn Fain says on a stream with Bernie Sanders. Fain says billionaires are "blaming immigrants or blaming DEI or blaming what bathroom somebody uses as a reason why your life sucks... We've got to not fall for those tactics."
Just two days after DNI Tulsi Gabbard’s declassification showing Fauci helped fund gain-of-function research and later conspired with the intelligence community to conceal the origins of COVID-19, The Washington Post published a smear piece on Gabbard while remaining silent on the alleged cover-up, per NYP.
Obama, the brutalist Manchurian Candidate birthed from the bowels of GCHQ