Indra_Bekere

Especially our collaborators Konstantin Sparrer, @PichlmairL, Katja Lammens, Lars König, @DorotaKmiec , Nadine Schwierz and Min Ae Lee-Kirsch!

Our manuscript on the dsRNA sensor OAS2 from the lab of @OliveiraMann is now out in @MolecularCell! Thanks to the whole team for their effort in putting this story together!

Structural Basis for OAS2 Regulation and its Antiviral Function biorxiv.org/content/10.110… #biorxiv_biochem

To sum up, our data bring a lot of new interesting insights in biology of OAS2. All this would not be possible without our collaborators @PichlmairL ,Konstantin Sparrer, Nadine Schwierz, Min Ae Lee-Kirsch and Lars Koening. Happy reading!

Finally, we also show a novel heterozygous OAS2 LOF mutation F524L leading to autoimmunity in a child. In our structure, we map this residue to catalytic domain II, which is strongly conserved across species and in other NTases and explains why the mutation destabilizes OAS2.

I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @OliveiraMann biorxiv.org/content/10.110…

@indrabekere.bsky.social

1/8 Publication Alert! Delighted to share the publication of a collaboration by Gerben Marsman (@zychlinsky lab @mpiib_berlin) and @xuhui_zheng (former PhD student in my lab) et al detailing how Histone H1 kills MRSA (cell.com/cell-reports/f…).

@simonjwenzl and I just published our perspective on cyclic nucleotide signalling @FEBS_Letters. It´s amazing how recent enzyme-centered approaches have pushed the borders of this field of research! doi.org/10.1002/1873-3…

Hohoho

Super happy to announce that our project NTasePro "NTase Products and Cyclic Nucleotide Signalling" has been selected by @ERC_Research for an ERC Starting Grant #ERCStG! Big thank you goes to the LS1 panel & reviewers and @TU_Muenchen for the support. tum.de/en/news-and-ev…

@TheBrysonLab My previous college did it successfully with Yersinia effectors ediss.sub.uni-hamburg.de/handle/ediss/8…

Any of my bacterial pathogenesis friends have any strains where a secreted effector is tagged with a GFP11 tag or have a secreted effector that is amenable to tagging? Would love to collaborate on an experiment if so!

@Pol2Runner @dfg_public @OliveiraMann Thank you for your help as well! :-)

@BekereIndra @dfg_public @OliveiraMann Congrats !!! Great news :)

So grateful and excited to have been granted funding for my postdoc project from Walter Benjamin Programme @dfg_public in the lab of @OliveiraMann working on nucleotide second messenger signaling!