bizarMD

Happy to share the latest preprint from our lab, “Somatic mutations distinguish melanocyte subpopulations in human skin”. biorxiv.org/content/10.110… [1]

@tangming2005 among other things we do to cells: pubmed.ncbi.nlm.nih.gov/36624340/ Considering "unglamorous" improvements unlocks clean data: nature.com/articles/s4301…

37 degrees Celsius. That is the temperature where your scRNA-seq experiment starts lying to you.

Review @NatureCancer @BizarMd @elhamazizi @Columbia Single-cell and spatial profiling in cancer biology and clinical oncology nature.com/articles/s4301…

Super proud of @zwalsh96. A great and well-deserved honor for your outstanding work. Excited to seeing more of your transformative research!

Congratulations, @rongejman!! Very well deserved. We are lucky to have you part of our clinical operation and lab.

It was an incredible honor to be hosted at @StanfordMed for the @StanfordPath annual retreat as the inaugural recipient of the national Galli Prize in Pathology! Endless thanks to @BizarMd for his mentorship and to the whole Izar lab family

Now also with a beautiful preview of the work by @SanchoShimizu cell.com/cell/abstract/…

Grateful for many outstanding collaborators in many departments/centers @columbiacancer @Columbia @ColumbiaMed @ColumbiaSurgery @ColumbiaBME and of course supporters of our lab @NIH @theNCI @PershingSqFdn @CancerResearch @vFound @MelanomaReAlli

Our data also suggest that subsequent metastatic behavior may be determined early in tumorigenesis and partly influenced by microenvironmental cues. More work on this intriguing concept forthcoming!...

We (Mori @MichaelMayMD @DrGManji ) find that in patients with resected pancreatic cancer isolated metastatic recurrence in the liver do worse than those with lung recurrence. We profiled (snRNA+lpWGS) their primaries & made an intriguing observation: nature.com/articles/s4158…

Really important study that extends principles of cancer neuroscience of primary brain tumors to that of brain metastasis (in this case, in small cell lung cancer). Congrats @humsav!!

Brilliant work. Necrosis is no longer just a non-specific process but active and NET pro-metastatic…

For this week’s #MRFResearchWednesday, we’re spotlighting 2025 Medical Student Grant Awardee @Zwalsh96 of @ColumbiaMed, working in the Izar Lab, with @BizarMd. His project, “Leveraging T Cell Genetic Variants to Enhance Melanoma Immunotherapies,” explores new ways to improve and strengthen treatments. Zach shares more about his research: “T cell immunotherapies, which harness the power of a patient’s own immune system to target and eliminate tumor cells, are becoming an increasingly promising treatment approach for melanoma, including for patients who do not respond to immune checkpoint inhibitors. However, many melanoma patients experience relapse or poor response after receiving these therapies, which highlights the critical need to engineer improved T cell therapies. As part of the Izar group at Columbia, my work aims to address this important gap." Read more about his work here: melanoma.org/news-press/mrf…

Now online! Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment dlvr.it/TLT5Xf

Thrilled to share the latest work from my PhD in the @BizarMd group! This has been a dream MD/PhD project, culminating in data that has already enabled access to precision therapy for a patient. Tweetorial below:

I am extremely grateful for support from @columbiacancer Human Tissue Immunology and Immunotherapy Initiative (HTI3) @PharmingGroupNV @NIH @NCICancerCtrl @CancerResearch

This was a big team effort with many folks from my lab @FrangiehChris @NeehaKothapalli @JCA_Melms Clarissa Heck & many more. Grateful for a fantastic collaboration with disease experts @joshuamilner2 @123456789Dusan

Excited to share a new paper: tinyurl.com/49u5e6by @CellCellPress: a framework to accelerate variant classification, diagnosis & treatment of immune disorders & genetic disorders more broadly. Led by superstar, juggernaut & future dermatologist @zwalsh96